A5031850233- Inflammatory Biomarkers in Disease Prognosis
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Dermatological and Skeletal Disorders
- Cervical Cancer and HPV Research
- Systemic Lupus Erythematosus Research
- Caveolin-1 and cellular processes
- Cancer Mechanisms and Therapy
- Renal Diseases and Glomerulopathies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sepsis Diagnosis and Treatment
- Mechanisms of cancer metastasis
- Cardiovascular and Diving-Related Complications
- Liver Diseases and Immunity
- Gout, Hyperuricemia, Uric Acid
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Antibiotic Use and Resistance
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
University of South China
2017-2025
Yichang Central People's Hospital
2025
Changhai Hospital
2025
Second Military Medical University
2025
First Affiliated Hospital of University of South China
2017-2022
First Affiliated Hospital of Harbin Medical University
2014-2017
Harbin Medical University
2013-2017
VA Boston Healthcare System
2015-2016
Brigham and Women's Hospital
2015-2016
Harvard University
2015-2016
Summary Inflammatory bowel disease (IBD)-associated thromboembolic event often lacks precise aetiology. The aim of this study was to investigate the contribution phosphatidylserine (PS) exposure and neutrophil extracellular traps (NETs) towards hypercoagulable state in IBD. We demonstrated that levels PS exposed MPs sources MP-origin, platelets, erythrocytes, leukocytes cultured endothelial cells (ECs) were higher IBD groups than healthy controls using flow cytometry confocal microscopy....
Sepsis is invariably accompanied by altered coagulation cascade; however, the precise role of phosphatidylserine (PS) in inflammation-associated coagulopathy sepsis has not been well elucidated. We explored possibility exposed PS on microparticles (MPs), blood cells, as endothelium, and defined its procoagulant activity (PCA) sepsis. PS-positive MPs cells were detected flow cytometry, while PCA was assessed with clotting time, purified complex, fibrin formation assays. Plasma levels PS+...
Objective To evaluate the role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), platelet-to-neutrophil (PNR), platelet-to-monocyte (PMR), and neutrophil-to-monocyte (NMR) as predictors for lupus nephritis (LN) patients without infection or biomarkers distinguishing between flare with LN patients. Methods were divided into three groups: infection, flare. A total 57 healthy subjects enrolled controls. The differentiation was analyzed control...
Abstract Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. There no approved therapeutic strategy for prevention vascular calcification. Sinomenine exhibited anti-inflammatory immunosuppressive effects. Objective this study was investigate effect sinomenine in its potential molecular mechanism. Adenine-induced uremic rats were constructed administrated with sinomenine. Optical clearing aortas, alizarin red staining, von...
Exploring the risk factors for mortality of hemodialysis patients undergoing COVID-19 and changes in before after opening epidemic northern Hunan province, China. We analyzed 230 with Yiyang Central Hospital from November 01, 2022 to February 28, 2023. Demographic data, laboratory data public diseases were collected. Cox regression analysis was used identify independent predictors mortality. The receiver operating characteristic (ROC) curve determine diagnostic value patients. average...
Abstract Background Recent studies have demonstrated the protective effect of physical activity on incident IBD, but underlying mechanism remain unclear. Here, large-scale circulating metabolomics data was used to identify a metabolic signature reflecting moderate-to-vigorous (MVPA). We then investigated whether this mediated association between MVPA and inflammatory bowel diseases (IBD) risk how genetic susceptibility IBD played roles in association. Methods The present study conducted two...
Abstract Background There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence. We investigated the associations of accelerometer-measured moderate-to-vigorous (MVPA) with resection risk and mortality among affected individuals. Methods collected data from 1,303 UK Biobank participants IBD diagnosis device-measured activity. MVPA was classified based measured by wrist-worn accelerometers over a 7-day...
Abstract Background Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) have been reported to be associated with inflammation in end-stage renal disease (ESRD) receiving dialysis. However, the value of NLR PLR non-dialysis patients ESRD remains unclear. Methods Among 611 The First Affiliated Hospital University South China (2012–2018), we compared high-sensitivity C-reactive protein (hs-CRP) levels ≤3 mg/L vs. > 3 mg/L. Correlation hs-CRP, PCT, ferritin were analyzed....
We evaluated cellular origin, numbers, and procoagulant activity of phosphatidylserine-positive microparticles (MPs) among subgroups in acute coronary syndromes (ACS).Parameters were measured on admission, days 1 (within 24 h admission), 2, 3, 7. All ST-elevated myocardial infarction (STEMI) patients presented more than 3 from symptom onset received fibrinolysis treatment; controls included unstable angina non-STEMI as well healthy controls. Phosphatidylserine-positive MPs detected by flow...
BackgroundRelatively little information is available about phosphatidylserine positive (PS+) microparticles (MPs) and their originating cells in IgA nephropathy (IgAN) despite well-established intraglomerular coagulation. Our objectives were to detect PS exposure on MP membranes MP-origin evaluate its role procoagulant activity (PCA) fibrin formation association with pathological lesions the disease.
Glioma is the most common primary brain tumor with poor prognosis. Effective treatment of glioma remains a big challenge due to complex pathogenic mechanisms. Previous studies have shown that metadherin (MTDH) and its interacting protein staphylococcal nuclease domain containing 1 (SND1) are overexpressed in many solid tumors. To elucidate role MDTH SND1 pathogenesis glioma, we examined expression MTDH tissues found both were highly expressed, similar patterns. Co-expression was associated...
<b><i>Background and Aim:</i></b> The study aimed to prospectively evaluate the effects of lowering dialysate calcium concentration (DCa) 1.25 mmol/l on Chinese patients undergoing maintenance hemodialysis (MHD), which are largely unknown date. <b><i>Methods:</i></b> A singer-center, prospective, randomized trial was conducted for 2 years. DCa in one group decreased from 1.5 but there no change other group. clinical outcomes, biochemical...
Abstract Background Hyperphosphatemia (HP) is associated with vascular calcification (VC) in chronic kidney disease (CKD). However, relationship between HP-induced-endothelial extracellular vesicles (HP-EC-EVs) and VC unclear, miR expression HP-EC-EVs has not been determined. Methods We isolated from endothelial cells HP observed that were up-taken by smooth muscle (VSMCs). inducing calcium deposition was characterized Alizarin Red S, colourimetric analysis ALP activity. To investigate the...
Reduced left ventricular ejection function (LVEF) was associated with increased mortality in patients peritoneal dialysis (PD) Asia and the United States of America. The neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) were correlated LVEF PD. However, little information is available regarding relationship between monocyte-to-lymphocyte (MLR), fraction (LVEF), use NLR, PLR, MLR predicting systolic dysfunction (LVSD) PD.All 181 PD enrolled 2014 2021 from Nephrology Department...
Background: Acute upper gastrointestinal bleeding (AUGIB) represents a major risk factor for mortality in patients with hepatocellular carcinoma (HCC) and liver cirrhosis. This retrospective observational study aimed to evaluate the prognostic performance of neutrophil lymphocyte ratio (NLR) albumin-bilirubin (ALBI) score assessment in-hospital outcomes cirrhotic HCC AUGIB. Methods: All consecutive AUGIB were included our study. The areas under receiving operator characteristics curves...