A5062791515- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Epigenetics and DNA Methylation
- Meningioma and schwannoma management
- Growth Hormone and Insulin-like Growth Factors
- Oceanographic and Atmospheric Processes
- Immune cells in cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Climate variability and models
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Neuroblastoma Research and Treatments
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- interferon and immune responses
- Protease and Inhibitor Mechanisms
- Meteorological Phenomena and Simulations
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
Shanghai Cancer Institute
2020-2024
Shanghai Jiao Tong University
2007-2024
Jinan University
2018-2024
Southwest Medical University
2024
Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital of Jinan University
2019-2024
Qilu University of Technology
2024
Shandong Academy of Sciences
2024
Shandong University
2024
Selective maintenance of genomic epigenetic imprints during pre-implantation development is required for parental origin-specific expression imprinted genes. The Kruppel-like zinc finger protein ZFP57 acts as a factor necessary maintaining the DNA methylation memory at multiple imprinting control regions in early mouse embryos and embryonic stem (ES) cells. Maternal-zygotic deletion mice presents highly penetrant phenotype with no animals surviving to birth. Additionally, several cases human...
Proportion and pathways of the eddy-induced heat transport are critical in maintaining world's ocean climate states. However, an observation-based three-dimensional picture how oceanic eddies contribute to global is yet not quantitatively specified, particularly due insufficiency data. Here, using refined methods, we have achieved this goal by analyzing millions high-quality Argo hydrographic profiles high-resolution satellite altimetric We first presented spatial differences individual...
Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, is identified nonhistone substrate of lysine acetyltransferase 6A (KAT6A). The acetylation at K20 and K117 by KAT6A promotes association with oncogenic chromatin modifier tripartite motif-containing 24 (TRIM24) disrupts interaction tumor suppressor TRIM33. This turn KAT6A-acetylated H3K23-mediated recruitment TRIM24-SMAD3 complex to thereby increases...
Abstract Resistance of breast cancer to human epidermal growth factor receptor 2 (HER2) inhibitors involves reprogramming the kinome through HER2/HER3 signaling via activation multiple tyrosine kinases and transcriptional upregulation. The heterogeneity induced prevents kinase targeting by a single inhibitor presents major challenge treatment therapeutically recalcitrant HER2-positive cancers (HER2+ BCs). As result, there is critical need for effective that attacks aberrant associated with...
Glioblastoma (GBM) is the most lethal primary brain tumor in adults with a median survival of around 15 months.A potential treatment strategy involves targeting glioma stem-like cells (GSCs) that are able to initiate, maintain, and repopulate mass.Here, we identify ACT001, parthenolide derivative, GSCs through regulation adipocyte enhancer binding protein 1 (AEBP1) signaling.Methods: The effects ACT001 on cell normal human astrocytes (NHA) patient-derived were evaluated.RNA-Seq performed...
Ovarian cancer is a fatal gynecologic malignancy that found worldwide and exhibits an insidious onset lack of early warning symptoms. Despite ongoing studies, the mechanistic basis aggressive phenotypes ovarian remains unclear. Lysine acetyltransferase 6A (KAT6A) MYST-type histone (HAT) enzyme identified as oncogene in breast cancer, glioblastoma leukemia. However, specific functions KAT6A remain
As the most common cause of progressive cognitive decline in humans, Alzheimer's disease (AD) has been intensively studied, but mechanisms underlying its profound synaptic dysfunction remain unclear. Here we confirm that exposing wild-type mice to an enriched environment (EE) facilitates signaling hippocampus promotes long-term potentiation (LTP). Exposing kept standard housing soluble Aβ oligomers impairs LTP, EE can fully prevent this. Mechanistically, key molecular features benefit are...
Background: Endometriosis (EM) is a long-lasting inflammatory disease that difficult to treat and prevent. Existing research indicates the significance of immune infiltration in progression EM. Efferocytosis has an important immunomodulatory function. However, on identification clinical efferocytosis-related genes (EFRGs) EM sparse. Methods: The EFRDEGs (differentially expressed genes) linked datasets associated with endometriosis were thoroughly examined utilizing Gene Expression Omnibus...
Abstract Background Neuroblastoma (NB) patients with amplified MYCN often face a grim prognosis and are resistant to existing therapies, yet protein is considered undruggable. KAP1 (also named TRIM28) plays crucial role in multiple biological activities. This study aimed investigate the relationship between NB. Methods Transcriptome analyses luciferase reporter assay identified that was downstream target of MYCN. The effects on cancer cell proliferation colony formation were explored using...
Adenomyosis (AM) is a common and challenging disease in gynecological clinics, which adversely affects women's physical mental health. Despite the growing number of studies, mechanisms associated with growth lesion are poorly understood. Studies show that abnormal proliferation, apoptosis, migration ectopic endometrial stromal cells (EESc) AM may contribute to development progression AM. Understanding underlying molecular can significantly diagnosing treating In present study, EESc was...
T cells and B participate in the pathogenesis of COPD. Currently, NK NKT have gained increasing attention. In present study, 19 COPD patients 12 healthy nonsmokers (HNS) were recruited, their pulmonary function was assessed. The frequencies CD3(+) T, CD4(+) CD8(+) B, NK, NKT-like determined using flow cytometry. spontaneous inducible IFN- γ (+) or CD107a(+) as well activating inhibitory receptors also detected. potential association lymphocyte subsets with disease severity further analyzed....
Mouse epiblast stem cells (EpiSCs) derived from postimplantation embryos are developmentally and functionally different embryonic (ESCs) generated blastocysts. EpiSCs require Activin A FGF2 signaling for self-renewal, similar to human ESCs (hESCs), while mouse LIF BMP4. Unlike ESCs, have undergone X-inactivation, the tendency of hESCs. The shared self-renewal X-inactivation properties hESCs suggest that they an epigenetic state distinct ESCs. This hypothesis predicts would monoallelic...
// Congxin Dai 1, * , Ming Feng Xiaohai Liu 1 Sihai Ma Bowen Sun Xinjie Bao Yong Yao Kan Deng Yu Wang Bing Xing Wei Lian Dingrong Zhong 2 Wenbin Renzhi Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy Sciences and College, Beijing 100730, China Pathology, These authors have contributed equally to this work Correspondence to: Wang, email: Wangrz@126.com Keywords: pituitary adenomas, refractory, resistance, recurrence, aggressive Received: June 16, 2016...
Abstract Machine learning-based data-driven models have achieved great success since their invention. Nowadays, the artificial neural network (ANN)-based machine learning methods made progress than ever before, such as deep and reinforcement learning, etc. In this study, we coupled ANN with K-nearest neighbor method to propose a novel hybrid (HML) hydrological model for flood forecast purpose. The advantage of proposed over traditional is that it can predict discharge continuously without...
Abstract The Philippine Sea is located within the pathway of propagating Madden‐Julian Oscillation system and also destination for North Pacific mesoscale oceanic eddies waves. As such, characterized by striking intraseasonal variability (ISV; 20–90 days) that plays a key role in bridging weather climate. Spatial patterns temporal features along coast are investigated using mooring observations outputs from an eddy‐resolving general circulation model. amplitude ISV determined sea level...