A5101883205- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Catalytic Processes in Materials Science
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gas Sensing Nanomaterials and Sensors
- Kruppel-like factors research
- Galectins and Cancer Biology
- Plant Micronutrient Interactions and Effects
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Protein Tyrosine Phosphatases
- RNA Interference and Gene Delivery
- Zebrafish Biomedical Research Applications
- RNA modifications and cancer
- Mercury impact and mitigation studies
- Genetic diversity and population structure
- Cytokine Signaling Pathways and Interactions
- Biosensors and Analytical Detection
- Genetic Mapping and Diversity in Plants and Animals
Chinese Academy of Sciences
2000-2024
University of Chinese Academy of Sciences
2024
Shanghai Jiao Tong University
2022-2024
Tongji University
2013-2024
Shanghai Tenth People's Hospital
2024
East China University of Science and Technology
2023-2024
University of California, Irvine
2022-2024
Qinghai University Affiliated Hospital
2020-2024
Zhoukou Normal University
2023
Zhongshan Hospital
2023
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding the effects naturally occurring genetic variation on molecular and organismal phenotypes. We used an integrated genotyping strategy identify 4,853,802 single nucleotide polymorphisms (SNPs) 1,296,080 non-SNP variants. Our population genomic analyses show higher deletion than insertion mutation rates stronger purifying selection deletions....
Epistasis—nonlinear genetic interactions between polymorphic loci—is the basis of canalization and speciation, epistatic can be used to infer networks affecting quantitative traits. However, role that epistasis plays in architecture traits is controversial. Here, we compared three Drosophila life history sequenced inbred lines melanogaster Genetic Reference Panel (DGRP) a large outbred, advanced intercross population derived from 40 DGRP (Flyland). We assessed allele frequency changes pools...
Inducible heat shock protein 70 (Hsp70) is one of the most important HSPs for maintenance cell integrity during normal cellular growth as well pathophysiological conditions. Tumor necrosis factor receptor‐associated 6 (TRAF6) a crucial signaling transducer that regulates diverse array physiological and pathological processes essential activating NF‐κB pathway in response to bacterial lipopolysaccharide (LPS). Here we report novel mechanism Hsp70 preventing LPS‐induced activation RAW264.7...
Abstract The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 ( GNPNAT1 ) is found significantly decreased CRPC compared with localized (PCa). Genetic loss-of-function CRPC-like cells increases proliferation and...
Metabolites serve as crucial biomarkers for assessing disease progression and understanding underlying pathogenic mechanisms. However, when the metabolic pathway category of metabolites is unknown, researchers face challenges in conducting metabolomic analyses. Due to complexity wet laboratory experimentation identification, there a growing demand predictive methods. Various computational approaches, including machine learning graph neural networks, have been proposed; however,...
Polarity proteins regulate the proliferation and differentiation of neural progenitors to generate neurons during brain development through multiple signaling pathways. However, how cell polarity couples pathways remains unclear. Here, we show that coiled-coil domain-containing protein 85c (Ccdc85c) interacts with Par3 radial glial cells (RGCs) via phase separation coupled percolation (PSCP). We find interaction Ccdc85c relieves intramolecular auto-inhibition Par3, which leads PSCP Par3....
Abstract Background Triple-negative breast cancer (TNBC) is a heterogeneous disease and we have previously shown that rapid relapse of TNBC associated with distinct sociodemographic features. We hypothesized versus late in also defined by clinical genomic features primary tumors. Methods Using three publicly-available datasets, identified 453 patients diagnosed adequate follow-up to be characterized as ‘rapid relapse’ (rrTNBC; distant or death ≤2 years diagnosis), ‘late (lrTNBC; > 2...
Abstract This study aims at comparing the inactivation of Bacillus subtilis spores by various combinations UV treatment and hydrogen peroxide (H 2 O ) addition. The included sequential (UV–H , H –UV) simultaneous (UV/H processes. Results showed that B. achieved a certain effect through treatment. However, hardly any alone was observed. had significant synergetic when combined with treatment, while high irradiance concentration both favored reaction. When treated 0.60 m 113.0 μW/cm for 6 min,...
Abstract Macroautophagy is a process that cells engulf cytosolic materials by autophagosomes and deliver them to lysosomes for degradation. The biogenesis of requires ATG2 as lipid transfer protein transport lipids from existing membranes phagophores. It generally believed endoplasmic reticulum the main source supply forming autophagosomes; whether can other organelles phagophores remains elusive. In this study, we identified new ATG2A-binding protein, ANKFY1. Depletion endosome-localized...
Performing organic reactions in water provides environmental and toxicity advantages compared to solvents, but such strategies are still evolving, limited by current understanding of these multiphasic systems. Here, a fluorescence lifetime imaging microscopy (FLIM) technique characterizes surfactant-dependent partitioning organics system that mimics the early, zinc-related steps Negishi-like cross-coupling reaction water, under synthetically relevant high concentrations substrate (0.18 M),...
To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma reveal the molecular mechanism carcinogenesis.Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases cancer constructed rats. Rats respectively sacrificed at d 14, 28, 56, 77, 105 112 after rats received DENA by gavage, then livers harvested. One part was classified according to their pathological changes, while...