A5084948134- Fluid Dynamics and Turbulent Flows
- Rocket and propulsion systems research
- Gene Regulatory Network Analysis
- Aerodynamics and Fluid Dynamics Research
- Genetic Associations and Epidemiology
- Radiative Heat Transfer Studies
- Energetic Materials and Combustion
- Bioinformatics and Genomic Networks
- Plasma Diagnostics and Applications
- Computational Fluid Dynamics and Aerodynamics
- Spacecraft Design and Technology
- Spacecraft and Cryogenic Technologies
- Computational Drug Discovery Methods
- Microbial Metabolic Engineering and Bioproduction
- Gene expression and cancer classification
- solar cell performance optimization
- Calibration and Measurement Techniques
- Wind and Air Flow Studies
- Gas Dynamics and Kinetic Theory
- Heat transfer and supercritical fluids
- Silicon and Solar Cell Technologies
- Fluid Dynamics and Vibration Analysis
- Pharmacogenetics and Drug Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Thermography and Photoacoustic Techniques
North Carolina State University
2013-2021
Bard College
2021
Foothill College
2021
United States Air Force Academy
2021
Juniata College
2021
Antioch College
2021
École Polytechnique Fédérale de Lausanne
2021
University of Lausanne
2021
George Mason University
2021
Kyoto University
2021
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding the effects naturally occurring genetic variation on molecular and organismal phenotypes. We used an integrated genotyping strategy identify 4,853,802 single nucleotide polymorphisms (SNPs) 1,296,080 non-SNP variants. Our population genomic analyses show higher deletion than insertion mutation rates stronger purifying selection deletions....
Abstract Introduction Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and specific gut‐brain axis neurodegeneration. Bile acids (BAs), products of cholesterol metabolism clearance, are produced liver further metabolized by bacteria. They have major regulatory signaling functions seem dysregulated Alzheimer's disease (AD). Methods Serum levels 15 primary secondary BAs their conjugated forms were measured 1464 subjects including 370 cognitively...
Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, nonprofit organizations to develop new research directions transform our understanding disease (AD) propel the development critically needed therapies. In response their recommendations, big data at multiple levels are being generated integrated study network failures in disease. We used metabolomics as a global biochemical approach identify peripheral metabolic...
Understanding of human variation in toxicity to environmental chemicals remains limited, so health risk assessments still largely rely on a generic 10-fold factor (10½ each for toxicokinetics and toxicodynamics) account sensitive individuals or subpopulations.We tested hypothesis that population-wide vitro cytotoxicity screening can rapidly inform both the magnitude molecular causes interindividual toxicodynamic variability.We used 1,086 lymphoblastoid cell lines from 1000 Genomes Project,...
Permutation testing is a robust and popular approach for significance in genomic research, which has the broad advantage of estimating non-parametrically, thereby safe guarding against inflated type I error rates. However, computational efficiency remains challenging issue that limits its wide application, particularly genome-wide association studies (GWAS). Because this, adaptive permutation strategies can be employed to make approaches feasible. While these have been used practice, there...
High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity chemicals.Our goal was to analyze dynamic using HCI identify "tipping point" at which cells did not show recovery towards a normal state.HCI used evaluate effects 967 chemicals (in concentrations ranging from 0.4 200 μM) on HepG2 over 72-hr exposure period. The end points included p53, c-Jun, histone H2A.x, α-tubulin, H3, alpha...
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative presenting major health and economic challenges that continue to grow. Mechanisms of are poorly understood but significant data point metabolic defects might contribute pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Neuroimaging Initiative (ADNI) creating a comprehensive biochemical database for AD. Using targeted non- metabolomics lipidomics platforms we mapping pathway network...
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found our environment and commerce. However, most assays have evaluated individual biological targets cancer cell lines lacking integrated physiological functionality (such as receptor signaling, metabolism). We differentiated HepaRGTM cells, human liver-derived model understood to effectively physiologically relevant hepatic...
Metformin is the first-line treatment for type 2 diabetes (T2D). Although widely prescribed, glucose-lowering mechanism metformin incompletely understood. Here, we used a genome-wide association approach in diverse group of individuals with T2D from Action to Control Cardiovascular Risk Diabetes (ACCORD) clinical trial identify common and rare variants associated HbA1c response followed up these findings four replication cohorts. Common PRPF31 CPA6 were worse better response, respectively (P...
Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates a class drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common rare genetic variants that impact lipid responses fenofibrate statin-treated patients T2D, we examined changes therapy using genomewide association study (GWAS). Associations were followed-up gene expression studies mice. Common SMAD3 IPO11 marginally associated...
The performance of eight possible propellants for electrothermal jet engines is evaluated theoretically. Performance characteristics are presented enthalpies up to 200,000 Btu/lb, temperatures as high 45,000 f R, pressures ranging from 0.0l l00 atm, and specific impulses 500 2000 sec. Of the studied, hydrogen helium appear be best impulse in vicinity 1000 At greater than 1600 sec, lithium becomes more efficient. (auth)
Aim: Association mapping with lymphoblastoid cell lines (LCLs) is a promising approach in pharmacogenomics research, and the current study we utilized LCLs to perform association for 29 chemotherapy drugs. Materials & methods: Currently, use genome-wide of cytotoxic response 520 European–Americans different anticancer drugs; largest LCL date. A novel using multivariate analysis covariance design was employed software program MAGWAS, testing differences dose–response profiles between...
Abstract Background With increasing knowledge about the potential mechanisms underlying cellular functions, it is becoming feasible to predict response of biological systems genetic and environmental perturbations. Due lack homogeneity in living tissues difficult estimate physiological effect chemicals, including toxicity. Here we investigate a biologically motivated model for estimating tissue level responses by aggregating behavior cell population. We assume that molecular state individual...
A new standard for medicine is emerging that aims to improve individual drug responses through studying associations with genetic variations. This field, pharmacogenomics, undergoing a rapid expansion due variety of technological advancements are enabling higher throughput reductions in cost. Here we review the advantages, limitations, and opportunities using lymphoblastoid cell lines (LCL) as model system human pharmacogenomic studies. There wide range publicly available resources...
Abstract Introduction Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and specific gut-brain axis neurodegeneration. Bile acids (BA), products of cholesterol metabolism clearance, are produced liver further metabolized by bacteria. They have major regulatory signaling functions seem dysregulated Alzheimer disease (AD). Methods Serum levels 15 primary secondary BAs their conjugated forms were measured 1,464 subjects including 370 cognitively...
Abstract Objective Determine the correlation between kaolin‐activated thromboelastography (TEG) variables (R, K, angle, and maximum amplitude [MA]) PCV, fibrinogen concentration (FC), total (TF) in an ex vivo model. Animals Two healthy adult mixed‐breed dogs. Procedures Citrated whole blood was obtained separated into packed red cells, platelet rich plasma, poor plasma (PPP). An aliquot of PPP heated to denature heat labile proteins (fibrinogen, factor V, VIII). Blood components were...