A5100330644- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Psoriasis: Treatment and Pathogenesis
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Atherosclerosis and Cardiovascular Diseases
- Folate and B Vitamins Research
- Acute Ischemic Stroke Management
- Monoclonal and Polyclonal Antibodies Research
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and genetic disorders
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Diabetes and associated disorders
- Cardiac Health and Mental Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Microscopic Colitis
- Metabolism and Genetic Disorders
- Hepatitis C virus research
- Cerebrospinal fluid and hydrocephalus
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
West China Medical Center of Sichuan University
2025
Peking University First Hospital
2019-2024
Peking University
2019-2024
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
China-Japan Friendship Hospital
2024
Zhongnan Hospital of Wuhan University
2024
Nantong University
2024
A recent study has reported that anti-reflux surgery reduced the risk of lung cancer. However, exact causal association between gastro-esophageal reflux disease (GORD) and cancer remains obscure. Therefore, we conducted a multivariable network Mendelian randomization (MR) to explore this potential mediation effect.Independent single nucleotide polymorphisms (SNPs) strongly associated with GORD were selected as instrumental variables (IVs) from corresponding genome-wide studies (GWAS). The...
Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that represents prodigious challenge of diagnosis and treatment. In 2019, under the leadership Chinese Rheumatology Association, multidisciplinary guideline development group was established to develop an evidence-based treatment for patients with SLE in PR China. The Grading Recommendations Assessment, Development Evaluation (GRADE) approach used evaluate quality evidence strength recommendations. reported...
Hemorrhagic stroke has a high mortality and disability rate. Among them, intraventricular hemorrhage (IVH) is an important factor leading to adverse outcomes. IVH can induce acute obstructive hydrocephalus chronic communicating hydrocephalus. However, there are currently no effective predictive factors for the early prediction of post-hemorrhage (PHH). To assess role inflammatory indicators in predicting PHH poor prognostic outcomes patients with ventricular hemorrhage. Single center...
Abstract Background Endovascular treatment (EVT) is gaining popularity for the management of severe forms cerebral venous thrombosis (CVT), but evidence supporting its efficacy and safety limited. Methods This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities China between January 2018 June 2022. Propensity score weighting models were used adjust baseline confounding variables determine association EVT on primary outcome good functional status,...
Abstract Aim Pulmonary arterial hypertension (PAH) is a complex and devastating complication of systemic lupus erythematosus (SLE). We sought to describe the baseline characteristics right heart catheterization (RHC)‐confirmed SLE‐associated PAH identify risk factors for in SLE patients. Methods A multicenter, cross‐sectional study was conducted using Chinese Treatment Research group (CSTAR) registry. Baseline data patients with without were collected compared. Risk among identified. Results...
A multidisciplinary guideline development group was established to formulate this evidence-based diagnosis and treatment guidelines for rheumatoid arthritis (RA) in China. The grading of recommendations, assessment, development, evaluation (GRADE) system used rate the quality evidence strength which were derived from research articles guided by analysis benefits harms as well patients' values preferences. total 10 recommendations RA developed. This new covered classification criteria,...
Abstract Background The objective of this study was to examine and analyze differential methylation profiles in order investigate the influence hyper-methioninemia (HM) on development diabetic nephropathy (DN). Male Wistar rats, aged eight weeks weighing 250–300 g, were randomly assigned into four groups: a control group (Healthy, n = 8), streptozocin-induced rats (STZ group, HM + STZ ( Tangshen Formula (TSF) treatment (TSF 8). Blood glucose levels other metabolic indicators monitored before...
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). This study assessed efficacy and safety tofacitinib in Chinese patients with RA enrolled Phase 3 long-term extension (LTE) studies.ORAL Sync was a 1-year, randomized, placebo-controlled, trial. Patients received 5 or 10 mg twice daily (BID) placebo advanced to BID at 6 months. All remained on ≥1 background conventional synthetic disease-modifying antirheumatic drug. ORAL Sequel open-label LTE...
The aim of this study was to evaluate the efficacy and safety biosimilar candidate adalimumab (HS016) compared with (Humira) for treatment active ankylosing spondylitis. A multicenter, randomized, double-blind, parallel, positive control, phase III clinical trial conducted at 28 locations in China. Patients spondylitis were randomized a 2:1 ratio subcutaneously receive 40 mg either HS016 or every other week 24 weeks. primary endpoint achieve least 20% improvement (ASAS20) patients weeks...
Objectives: To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA). Methods: In this multicenter, randomized parallel trial, 346 active RA (disease activity score (28 joints) [DAS28] (erythrocyte sedimentation rate [ESR]) > 5.1) were enrolled from 9 centers. phase 1, received methotrexate, leflunomide, hydroxychloroquine, up 36 weeks, until (DAS28 ≤...
Traumatic brain injury (TBI) represents a common and severe medical condition necessitating prompt risk stratification to enhance patient outcomes. Although substantial research has been conducted on the prognostic utility of various biomarkers for TBI, no single biomarker definitively recognized as most precise predictor disease In comparison other markers, neutrophil-albumin ratio (NAR) emerged cost-effective reproducible inflammatory biomarker, demonstrating potential in evaluating...
Objectives: The aim of this noninferiority study was to investigate clinical effectiveness and safety buprenorphine transdermal system (BTDS) in patients with moderate severe musculoskeletal pain inadequately controlled nonsteroidal anti-inflammatory drugs, compared sustained-release tramadol tablets. Materials Methods: Eligible were randomized (1:1) receive low-dose 7-day BTDS (5, 10, 20 μg/h, maximum dosage μg/h) or tablets (100 mg, 400 mg/d) over an 8-week double-blind treatment period...
Abstract Introduction There is no well‐recognized biomarker for accurately predicting outcome in the presence of moyamoya disease ( MMD ), a progressive occlusive cerebrovascular internal carotid arteries or their branches. The aim this study was to investigate endothelial progenitor cells EPC s) and circulating CEC correlate findings with clinical features. Methods Patients n = 66) were compared healthy controls 81). Blood samples obtained from an antecubital vein analyzed using flow...