A5048692113- Fibroblast Growth Factor Research
- Ion channel regulation and function
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Nicotinic Acetylcholine Receptors Study
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Cellular Mechanics and Interactions
- Hedgehog Signaling Pathway Studies
- PI3K/AKT/mTOR signaling in cancer
- Neuroscience and Neuropharmacology Research
- Planarian Biology and Electrostimulation
- 3D Printing in Biomedical Research
- Cancer, Lipids, and Metabolism
- Neuroscience and Neural Engineering
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- Genetic factors in colorectal cancer
- Ion Channels and Receptors
- Myasthenia Gravis and Thymoma
- Ion Transport and Channel Regulation
Kingston University
2016-2025
Queen Mary University of London
2007-2015
Cancer Research UK
2012
Imperial College London
2004-2009
Abstract Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution cancer progression has largely been ignored. The purpose of this study was investigate voltage-gated Na+ (VGSC) expression its possible role human breast cancer. Experimental Design: Functional VGSC investigated cell lines by patch clamp recording. directional endocytosis, invasion...
FGF-10 and its receptors, FGFR1 FGFR2, have been implicated in breast cancer susceptibility progression, suggesting that fibroblast growth factor (FGF) signaling may be co-opted by cells. We identify a novel pathway downstream of activation, whereby the receptor is cleaved traffics to nucleus, where it can regulate specific target genes. confirm Granzyme B (GrB) as protease responsible for cleavage show blocking GrB activity stopped trafficking nucleus abrogates promigratory effect FGF...
Whole‐cell patch‐clamp recordings showed that a sub‐population (10%) of Jurkat cells, model human T‐cells, expressed functional voltage‐gated sodium channel, which was tetrodotoxin (TTX)‐resistant. Expression channel protein confirmed by western blots. Semi‐quantitative PCR analysis revealed mRNAs for the α‐subunits multiple subtypes were present but indicated Na v 1.5 predominant subtype, consistent with TTX‐resistant nature recorded currents. Importantly, 10 μM TTX reduced number cells...
Primary or acquired resistance to therapeutic agents is a major obstacle in the treatment of cancer patients. Cervical fourth leading cause deaths among women worldwide and, despite advances screening and treatments, many patients with advanced stage cervical have high recurrence rate within two years standard treatment, drug being contributing factor. The development cell lines can facilitate comprehensive investigation mechanisms, which cannot be easily performed clinical trials. This...
Genomic changes affecting tumour suppressor genes are fundamental to cancer. We applied SNP array analysis a panel of testicular germ cell tumours search for novel and identified frequent small deletion on 6q25.3 just one gene, ZDHHC14. The expression ZDHHC14, putative protein palmitoyltransferase with unknown cellular function, was decreased at both RNA levels in tumours. ZDHHC14 also significantly prostate cancer samples lines. In addition our findings genetic clinical samples, inducible...
One of the leading causes death worldwide, in both man and woman, is cancer. Despite significant development therapeutic strategies, inevitable emergence drug resistance limits success impedes curative outcome. Intrinsic acquired are common mechanisms responsible for cancer relapse. Several factors crucially regulate tumourigenesis resistance, including physical barriers, tumour microenvironment (TME), heterogeneity, genetic epigenetic alterations, immune system, burden, growth kinetics...
Cervical cancer is one of the most frequently diagnosed cancers in women worldwide. While cervical caused by human papillomavirus (HPV), not all females infected with HPV develop disease, suggesting that other factors might facilitate its progression. Growing evidence supports involvement fibroblast growth factor receptor (FGFR) axis several cancers, including gynecological. However, for cancer, molecular mechanisms underpin disease remain poorly understood, role FGFR signaling. The aim this...
Fibroblast Growth Factors play critical roles during development, tissue homeostasis and repair by controlling cell proliferation, survival, migration differentiation. Of the 22 mammalian FGFs, FGF22, a member of FGF7/10/22 subfamily, has been shown to have clear role in synaptogenesis, but its other tissues not studied. We investigated vivo functions FGF22 mice. Fgf22 null animals were viable, fertile did display any obvious abnormalities. Despite known expression profile skin, no...
The advent of co-culture approaches has allowed researchers to more accurately model the behaviour epithelial cells in cell culture studies. initial work on epidermal modelling development reconstituted epidermis, growing keratinocytes top fibroblasts seeded a collagen gel at an air-liquid interface generate terminally differentiated 'skin equivalents'. In addition developing ex vivo skin sheets for treatment burns victims, such cultures have also been used as means investigating both and...
Abstract Tumor suppressor genes (TSGs) play critical roles in preventing tumorigenesis and they are frequently inactivated tumours. Recently developed high-density microarrays can detect subchromosomal deletions, recurrence of which usually indicates the location TSGs within deleted region. We analyzed testicular germ cell tumour (TGCT) clinical samples using SNP arrays found a frequent small deletion on region 6q25.3 containing only one known gene, ZDHHC14. While its cellular function is...