A5076795537- Proteoglycans and glycosaminoglycans research
- Osteoarthritis Treatment and Mechanisms
- Bone health and osteoporosis research
- Glycosylation and Glycoproteins Research
- Hip and Femur Fractures
- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Bone Tissue Engineering Materials
- Cell Adhesion Molecules Research
- Bone health and treatments
- Inflammatory mediators and NSAID effects
- Bone fractures and treatments
- Carbohydrate Chemistry and Synthesis
- Connective tissue disorders research
- Nutrition and Health in Aging
- Health disparities and outcomes
- Fibroblast Growth Factor Research
- Monoclonal and Polyclonal Antibodies Research
- Parathyroid Disorders and Treatments
- Galectins and Cancer Biology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Obesity, Physical Activity, Diet
- Collagen: Extraction and Characterization
Queen's University
2011-2022
Center for Rheumatology
2004-2014
Universität Hamburg
2013
University Medical Center Hamburg-Eppendorf
2013
McGill University
1967-2010
University of Toronto
2009-2010
University of Calgary
2009-2010
University of British Columbia
2009-2010
University of Saskatchewan
2009
Université Laval
2009
Osteoporosis is a recognized complication of corticosteroid therapy. Whether it can be prevented not known. We conducted 12-month, randomized, placebo-controlled study intermittent etidronate (400 mg per day for 14 days) followed by calcium (500 76 days), given four cycles, in 141 men and women (age, 19 to 87 years) who had recently begun high-dose The primary outcome measure was the difference change bone density lumbar spine between groups from base line week 52. Secondary measures...
<b>Background:</b> Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality. <b>Methods:</b> A total 7753 randomly selected people (2187 men 5566 women) aged 50 years older from across Canada participated in a 5-year observational cohort study. Incident were identified basis validated self-report classified type (vertebral, pelvic, forearm wrist, rib, hip "other"). subdivided...
We aimed to explore whether frailty was associated with fracture risk and could modify the propensity of type 2 diabetes toward increased fractures.Data were from a prospective cohort study. Our primary outcome time first incident clinical fragility fracture; secondary outcomes included hip spine fracture. Frailty status measured by Index (FI) deficit accumulation. The Cox model incorporating an interaction term (frailty × diabetes) used for analyses.The analysis 3,149 (70% women)...
This cross-sectional cohort study of 5566 women and 2187 men 50 years age older in the population-based Canadian Multicentre Osteoporosis Study was conducted to determine whether reported past diseases are associated with bone mineral density or prevalent vertebral deformities. We examined 12 self-reported disease conditions including diabetes mellitus (types 1 2), nephrolithiasis, hypertension, heart attack, rheumatoid arthritis, thyroid disease, breast cancer, inflammatory bowel...
Twenty-six patients with rheumatoid arthritis (average age, 57 years; average duration of disease, 11 years) who were unresponsive to antiinflammatory and slow-acting antirheumatic drug therapy entered into a controlled, double-blind, crossover study assess the efficacy plasmapheresis therapy. All received 10 true sham aphereses as outpatients continued take their usual drugs. Twenty completed study, six withdrawn — three because poor venous access. Standard clinical laboratory measures...
Recent knowledge of the cellular and molecular mechanisms underlying cutaneous wound healing has advanced development medical products. However, patients still suffer from failure current treatments, due to complexity process thus novel therapeutic approaches are urgently needed. Previously, our laboratories produced a range low weight hyaluronic acid (LMW-HA) fragments, where proportion glucosamine moieties were chemically N-acyl substituted. Specifically, N-butyrylation results in...
Abstract Background Previous research has shown that underlying dietary patterns are related to the risk of many different adverse health outcomes, but relationship these skeletal fragility is not well understood. The objective study was determine whether in men (ages 25-49, 50+) and women (pre-menopause, post-menopause) femoral neck bone mineral density (BMD) independently other lifestyle variables, this mediated by body mass index. Methods We performed an analysis 1928 4611 participants...
The frequency and incidence of certain forms toxicity in patients receiving long term chrysotherapy for rheumatoid arthritis have been reliably calculated defined, sequential time periods. Ninety-four who received 100 courses gold therapy a total treatment period 134.4 patient-years were followed at one clinic. For the 0--3 months, incidences rash, mouth ulcer, proteinuria 9.8, 4.0, 1.8 episodes per 10,000 patients/month, respectively. However, these decreased progressively subsequent...