A5014039380- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Case Reports on Hematomas
- Urticaria and Related Conditions
- Alcohol Consumption and Health Effects
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Biochemical and Molecular Research
- Liver physiology and pathology
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Chronic Disease Management Strategies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Hepatitis C virus research
Sun Yat-sen University
2022
Changhai Hospital
2015-2020
Second Military Medical University
2015-2020
Xinjiang Institute of Materia Medica
1992
Abstract Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with urate gout. However, their influence on the progression elevated levels to gout unclear. This study aims explore systematically effects of genetic variants pathogenesis in approximately 5,000 Chinese individuals. Six genes ( PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A ) were determined be P FDR < 0.05) population for first time. ABCG2 novel gene, SLC17A4 ,...
In this study, we analyzed single nucleotide polymorphisms (SNP) in urate transporter genes to examine the pathogenesis of gout.We conducted a 1:1-matched case-control study that included 110 patients with acute gout attacks as patient group and healthy age-and gender-matched subjects control group.Clinical parameters were recorded blood biochemistry tests for both groups.Multivariate logistic regression analysis was used analyze data.Hyperuricemia, hypercholesterolemia, hypertriglyceridemia...
Abstract Elevated serum urate, which is regulated at multiple levels including genetic variants, a risk factor for gout and other metabolic diseases. This study aimed to investigate the association between UCP2 variants urate as well hyperuricemia in Chinese population. In total, 4332 individuals were genotyped two common −866G/A Ala55Val. These loci not associated either level or with of total group subjects. However, females, Ala55Val lower ( P = 0.006 0.014, seperately) played protective...
Gout is a common inflammation disease resulting from an increase in serum uric acid. Nearly 70% of acid excreted via the kidneys. To date, evidence for association between genetic loci and gout absent, equivocal or not replicated. Our study aims to test variants two genes abundantly expressed kidney, LRP2 COMT, their with gout. In total, 1318 Chinese individuals were genotyped rs2544390 rs4680 COMT. These COMT gene polymorphisms showed no significant effect on (P = 0.204 0.188, separately);...
This 24-week randomized, double-blind, non-inferiority study compared the efficacy and safety of febuxostat, a xanthine oxidase inhibitor, with allopurinol using an up-titration method in hyperuricemic Chinese subjects or without gout. Eligible adults (serum uric acid [SUA] > 7.0 mg/dl history gout, SUA ≥ 8.0 complications 9.0 complications) were randomized (1:1:1) to febuxostat 40 mg/day, 80 300 mg/day. Starting doses 20 mg/day 100 up-titrated, up 16 weeks, maintained week 24. Primary...
Depression is one of the most common comorbidities in patients with chronic lung diseases (CLDs). Depressive symptoms have an obvious influence on health function, treatment, and management CLD patients. In order to investigate additional medical expenditure caused by depressive among middle-aged elderly CLDs China, estimate urban–rural differences expenditure, our study used data from 2018 China Health Retirement Longitudinal Study (CHARLS) investigation. A total 1834 were included this...
Abstract Background Genetic background affects serum urate concentration and gout risk, especially regarding these variants in the urate-transporter gene ABCG2 . However, role of epistasis between PKD2 on pathogenesis is poorly understood. Here we assess this epistatic interaction progression from elevated to gout. Results We identified two pairs (rs2728121: rs1481012 rs2728121: rs2231137) were associated with levels 4914 Chinese individuals ( P int = 0.018 0.004, respectively). Using...
The aims of this study were to identify candidate pathways associated with serum urate and explore the genetic effect those on risk gout. Pathway analysis loci identified in genome-wide association studies (GWASs) showed that ion transmembrane transporter activity pathway (GO: 0015075) secondary active 0015291) both concentrations, PFDR values 0.004 0.007, respectively. In a Chinese population 4,332 individuals, two also found be (PFDR = 1.88E-05 3.44E-04, separately). addition, these...
Our objective was to explore the molecular pathogenesis of onset gout and mechanism underlying effect interleukin (IL)-37 on PDZ domain-containing 1 (PDZK1) protein through nuclear factor-κB signaling pathway.Real-time PCR western blotting were used detect expression PDZK1 mRNA protein, respectively, in HK-2 cell line. The inhibitors pyrrolidine dithiocarbamate (PDTC) wortmannin added cells stimulated by IL-37, changes detected blotting.Based our previous research, we 10 µmol/L PDTC. We no...
Abstract Background Uric acid is the final product of purine metabolism and elevated serum urate levels can cause gout. Conflicting results were reported for effect PKD2 on gout risk. Therefore, our study attempted to state important role in influencing pathogenesis Method SNPs (rs2725215 rs2728121) ABCG2 (rs2231137 rs1481012) tested approximately 5,000 Chinese individuals. Results Two epistatic interactions between loci (rs2728121) (rs1481012 rs2231137) showed distinct contributions uric...