A5100729804- Alzheimer's disease research and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Folate and B Vitamins Research
- Dementia and Cognitive Impairment Research
- Air Quality and Health Impacts
- Healthcare professionals’ stress and burnout
- Membrane Separation and Gas Transport
- Trace Elements in Health
- GDF15 and Related Biomarkers
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatitis B Virus Studies
- Nutrition and Health in Aging
- Indoor Air Quality and Microbial Exposure
- Smart Materials for Construction
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- RNA regulation and disease
- Adsorption and biosorption for pollutant removal
- Health, psychology, and well-being
- Optical Imaging and Spectroscopy Techniques
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune Neurological Disorders and Treatments
- Inhalation and Respiratory Drug Delivery
Guangzhou Medical University
2017-2024
Guangzhou First People's Hospital
2020-2024
South China University of Technology
2020-2024
First Affiliated Hospital of Guangzhou Medical University
2017-2021
State Key Laboratory of Respiratory Disease
2017-2021
State Key Laboratory of Pollution Control and Resource Reuse
2007
Nanjing University
2007
National University of Singapore
2007
In the present study we prepared a hyper-cross-linked polymeric adsorbent (NDA-701) possessing uniquely bimodal pore size distribution for 4-nitrophenol (4-NP) adsorption from water. A macroporous Amberlite XAD-4 and granular activated carbon GAC-1 were chosen comparison. NDA-701 exhibited better mechanical strength higher capacity of 4-NP than XAD-4, which possibly resulted its hyper-cross-linking nature micropore structure, respectively. isotherm onto is well described by Freundlich model,...
Background: Plasma-based biomarkers would be potential for early diagnosis of Alzheimer's disease (AD) because they are more available and cost-effective than cerebrospinal fluid (CSF) or neuroimaging. Therefore, we aimed to evaluate whether phosphorylated tau181 (p-tau181) in plasma could an accurate AD predictor. Methods: Participants from the ADNI database included 185 cognitively unimpaired subjects with negative Aβ (CU–), 66 pre-clinical (CU positive Aβ), 164 mild cognitive impairment...
Background: The sudden outbreak of COVID-19 has caused mental stress on healthcare workers (HCW). This study aimed to assess their psychological health status at the peak and identify some coping strategies. Methods: A cross-sectional survey was conducted during COVID-19. completed by 908/924 HCW (response rate 98.27%) in government-designated hospitals Guangdong, China. quality life (QoL) scale, Zung Self-Rating Anxiety Scale (SAS), Depression (SDS) were used evaluate status. Logistic...
Biomass fuel smoke is thought to contribute chronic obstructive pulmonary disease, which characterized by mucous cell metaplasia and enhanced mucus secretion. We investigated the effect of particulate matter (PM) with a diameter <2.5 μm (PM2.5) from wood (WSPM2.5) on expression most prominent secreted mucin, MUC5AC. Wood was able induce MUC5AC in rat respiratory tract after 3 months exposure. WSPM2.5 could production both primary human airway epithelial cells NCI-H292 line. This induction...
Abstract Depression is one of the most common psychiatric diseases worldwide. With increase in number depressive episodes, cognitive dysfunction may be accelerated. Although significant findings related to pathogenesis depression have been reported, precise molecular mechanisms depression-related disorders not yet fully clarified. In this study, we collected serum copper levels and evaluated functions patients with major disorder (MDD) healthy controls. Furthermore, adopted a chronic...
To investigate the relationship between homocysteine levels and post-stroke cognitive impairment (PSCI) in Chinese female male populations with minor acute ischemic stroke or transient attack.A total of 1070 participants clinically confirmed attack baseline information from a nationwide multicenter prospective registry study China were included this study. Of these, 919 patients had assessments at 3-month follow-ups 584 12-month follow-ups. The incidence PSCI was defined as Montreal...
The ε4 allele of the apolipoprotein E (APOE) gene is a strong genetic risk factor for aging-related cognitive decline. However, causal connection between alleles and cognition not well understood. objective this study was to identify roles cerebral blood flow (CBF) in cognitive-related brain areas mediating associations APOE with cognition.The multiple linear regression analyses were conducted on 369 subjects (mean age 68.8 years; 62.9% women; 29.3% carriers). Causal mediation 5,000...
Background Disruption of the blood–brain barrier (BBB) is an important pathophysiological process anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. A recent multi-center study showed that soluble (s) CD146 a potential biomarker for monitoring early BBB damage and central nervous system inflammation, but little known about sCD146 in anti-NMDAR Method Twenty-three encephalitis patients seventeen controls with non-inflammatory neurological diseases were recruited. inflammatory...
Background and Objective: To determine the effects of BSE (biomass smoke exposure) on pulmonary non-pulmonary changes in patients with COPD compared normal individuals. Methods: Using a cohort, we recruited 16 healthy individuals (BSE normal), 19 BSE+COPD, 13 cigarette exposure (CSE 25 CSE+COPD, controls. Patients GOLD stage I II were included. Baseline data (demographic data, or CSE, lung function, CT findings) follow-up function collected. parameters emphysema, small vessels, airway...
Abstract Background Biomass smoke exposure (BSE) is an important etiological factor in chronic obstructive pulmonary disease (COPD). However, few studies have focused on the effects of BSE respiratory muscles or lungs. Methods Using a cohort, we selected 98 participants underdeveloped rural areas: 16 healthy individuals with (“BSE normal”), 19 patients and COPD (“BSE+COPD”), 13 cigarette (“CSE 25 (“CSE+COPD”), controls. Patients GOLD stage I II were included. Baseline data (demographic data,...