A5101569276- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Congenital gastrointestinal and neural anomalies
- Neuroblastoma Research and Treatments
- Asthma and respiratory diseases
- Fungal Infections and Studies
- Whipple's Disease and Interleukins
- Cancer Immunotherapy and Biomarkers
- Vasculitis and related conditions
- Cell Adhesion Molecules Research
- Renal and related cancers
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Metastasis and carcinoma case studies
- Intestinal Malrotation and Obstruction Disorders
- Urological Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Vitamin D Research Studies
- Allergic Rhinitis and Sensitization
- Head and Neck Cancer Studies
- Congenital Diaphragmatic Hernia Studies
Children's Hospital of Fudan University
2012-2024
Chinese People's Liberation Army
2021
Weatherford College
2020
Beijing Normal University
2020
Chinese PLA General Hospital
2002-2019
Xiangya Hospital Central South University
2019
Central South University
2019
Boston Children's Hospital
2015
Fudan University
2014
People's Liberation Army No. 150 Hospital
2011
ABSTRACT The pathogenesis of CRC remains to be further understood. This study was designed elucidate the role Foxp3+IL-17+ T cells in CRC. Surgically removed tissue collected from 12 patients with frequency and cytokine profile were examined by flow cytometry. Chemokine CXCL11 Western blotting. Treg chemotaxis a transwell system. effect on induction cancer-initiating examined; latter's Akt MAPK activities colony formation afterward. Abundant detected that expresses high levels TGF-β, CXCR3,...
Highlights•High-fat diet induces colonic lysine homocysteinylation (K-Hcy) catalyzed by MARS•Increased MARS copy number is a risk factor for human colorectal cancer (CRC)•K-Hcy impedes DNA damage repair in CRC•K-Hcy inhibition decreases high-fat-induced oncogenic effectsSummaryColorectal (CRC) onset profoundly affected Western diet. Here, we report that high-fat (HF) diet-induced, organ-specific increase might promote CRC impeding repair. HF chow induced elevated methionyl-tRNA synthetase...
Thyroid carcinoma is the most common endocrine malignancy and a cancer among malignancies of head neck. Noninvasive convenient biomarkers for diagnosis papillary thyroid (PTC) as early possible remain an urgent need. The aim this study was to discover identify potential protein PTC specifically.Two hundred twenty four (224) serum samples with 108 116 controls were randomly divided into training set blind testing set. Serum proteomic profiles analyzed using SELDI-TOF-MS. Candidate purified by...
Interleukin (IL)-10 plays an important role in immune regulation the intestine. Immune deregulation is suggested pathogenesis of inflammatory bowel disease (IBD). This study aims to elucidate IL-23 suppression IL-10 IBD intestinal mucosa. Surgically removed colon specimens were obtained from 16 patients. The expressions IL-10, IL-23, and IgA examined at protein gene transcriptional levels. transcription was assessed by chromatin immunoprecipitation assay promoter accessibility assay. levels...
To study the clinical and epidemiological profile of Pityriasis versicolor (PV) to determine possible genetic model for PV in Chinese Han, we investigated 503 patients with who were recruited by a questionnaire method. Statistical analysis, heritability complex segregation analysis performed using EPI INFO 6.0, SPSS 10.0, Falconer method SAGE-REGTL programs. In total patients, mean age onset was 22.85 +/- 10.36 years. For male female peak ages initial both 20-29 A 106 (21.1%) reported have...
Abstract Objectives To explore the clinical characteristics, postnatal treatment and prognosis of giant fetal hepatic hemangioma (GFHH). Method Retrospective analysis was performed on children with (maximum tumor diameter > 40 mm) diagnosed by prenatal ultrasound MRI from December 2016 to 2020. These patients were observed treated at Children’s Hospital Fudan University after birth. The data collected analyze treatment, GFHH using independent sample t tests or Fisher’s exact tests....
SOX2 is a transcription factor associated with the pluripotency, proliferative potential, and self-renewing properties observed embryonic stem cells germ cells. expression has been reported in several cancers implicated tumorigenesis. We previously found that was correlated to clinical stage of neuroblastoma. Recently, we overexpression occurs I-type neuroblastoma (BE(2)-C cells). To elucidate tumorigenic function SOX2, established overexpressed BE(2)-C cell line. showed higher...
Objective. Aberrant expression of immunoglobulin (Ig) by cancer cells has been documented in a number malignant tumors but its biological significance is unclear. Cancer overexpress anti-apoptotic molecules such as Bcl-xL. The present study aimed to examine the role Ig light-chain Igĸ and Igλ maintaining high levels Bcl-xL colorectal cells. Material methods. Thirty patients with were recruited this study. Expression Igĸ, surgically removed tissue was examined immunohistochemistry and/or flow...
Hirschsprung's disease (HSCR) is a congenital digestive tract malformation characterized by the absence of intramural ganglion cells in myenteric and submucosal plexuses along variable lengths gastrointestinal tract. Although improvement surgical methods has allowed great progress treatment HSCR, its incidence postoperative prognosis are still not ideal. The pathogenesis HSCR remains unclear to date. In this study, metabolomic profiling serum samples was performed an integrated analysis gas...
Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene an important anti-cancer in body, which suppressed cancer. ubiquitin E3 ligase A20 (A20) plays a role regulating activities of epithelial cells. This study was designed to investigate polyp epithelium-derived cancer.Eighty-eight cancer patients and 136 were recruited this study. Human tissue, epithelium adenomas hyperplastic showed high levels A20, had positive correlation with cancerous...
Colorectal carcinomas are common in adults; however, they rarely occur children. The present study reported the case of a colorectal carcinoma diagnosed as signet-ring cell 9-year-old boy. patient presented with acute intestinal obstruction symptoms, which persisted following 3 days conservative treatment. diagnosis was determined by emergency laparotomy and mass identified transverse colon proximal to splenic flexure. Histological examination revealed carcinoma. In addition, aimed discuss...
This study aimed to evaluate the efficacy of bowel plication as a part surgical treatment in neonatal high jejunal atresia.Between January 2013 and December 2016, 43 neonates with atresia underwent at Children's Hospital Fudan University. According procedures patients underwent, were divided into group nonplication group. Eighteen proximal after atretic segment resection primary anastomosis. The other 25 enteroplasty resection. Data retrospectively analyzed, including gestational age, birth...
Abstract Background Some studies have shown discrepancies in human leucocyte antigen (HLA) associated with alopecia areata (AA) between different ethnic populations. Objective To investigate whether HLA‐I, ‐DQA1 and ‐DQB1 alleles the HLA haplotype are AA, correlation profile, age of onset severity AA Chinese Hans. Methods The polymerase chain reaction‐sequence specific primer (PCR‐SSP) method was used to analyse frequencies class I, 192 patients 252 controls linkage disequilibrium calculated...
Rationale: Takayasu arteritis (TA) is a chronic granulomatous inflammation affecting the aorta and its main branches. The clinical symptoms are mainly due to arterial claudication end-organ ischaemia. Abdominal pain an uncommon manifestation of TA. Patient concerns: We present rare case TA in 13-year-old boy who first presented with abdominal pain. An emergency aortic stent implantation aneurysm embolization were performed, intra-operative diagnosis was pseudoaneurysm. Diagnoses: A...