Abstract Background Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in management IH, suggesting β-adrenergic receptors (β-ARs) may play an important role pathogenesis IH. Results In present study, we investigated signaling associated with hemangioma-derived cell (HemEC) proliferation. The results showed both β 1 - 2 -ARs were expressed...

Abstract. In order to better understand the particle size distribution of polycyclic aromatic hydrocarbons (PAHs) and their source contribution human respiratory system, size-resolved PAHs have been studied in ambient aerosols at a megacity Shanghai site during 1-year period (2012–2013). The results showed had bimodal with one mode peak fine-particle range (0.4–2.1 µm) another coarse-particle (3.3–9.0 µm). Along increase ring number PAHs, intensity fine-mode increased, while coarse-mode...

Abstract Background Food addiction and an impulsive personality can increase overeating, which lead to weight gain. The amygdala nucleus accumbens (NAcc) are critical for regulating obesogenic behaviour. However, whether the or NAcc acts as neural basis regulation of food addiction, personality, body remains unclear. Methods We examined differences in volume NAcc, especially lateralization index (LI), between 33 obese participants 39 age- sex-matched healthy controls. associations LI each...

Postoperative cognitive dysfunction (POCD) is a frequent complication in elderly patients undergoing major non-cardiac surgery, but its etiology still unclear. Cerebral oxygen saturation (ScO2) represents the balance of cerebral supply and demand. The aim present study was to evaluate relationship between perioperative ScO2 POCD, verify hypothesis that value after multiple influential factors could predict POCD total knee arthroplasty (TKA). Seventy eight Patients aged more than 65 years...

The purpose of this study was to compare the efficacy and safety dexmedetomidine versus remifentanil for sedation during awake intubation using a Shikani optical stylet (SOS). Sixty-eight patients with cervical trauma or severe spondylosis undergoing spinal surgery were enrolled in prospective study. They randomly assigned receive (Group D) R). In Group D, received an intravenous loading dose 1 μg · kg−1 over 10 min followed by continuous infusion 0.7 h−1. R, target-controlled administered...

SOX2 is a transcription factor associated with the pluripotency, proliferative potential, and self-renewing properties observed embryonic stem cells germ cells. expression has been reported in several cancers implicated tumorigenesis. We previously found that was correlated to clinical stage of neuroblastoma. Recently, we overexpression occurs I-type neuroblastoma (BE(2)-C cells). To elucidate tumorigenic function SOX2, established overexpressed BE(2)-C cell line. showed higher...

Pulmonary fibrosis frequently occurs in rheumatic conditions, particularly systemic sclerosis-associated interstitial lung disease (SSc-ILD). The pathology involves cell transformation into structures and collagen accumulation. CD4+LAG3+T cells, known for immune inhibition, are relevant autoimmunity. This study investigates cells SSc-ILD. Clinical analysis revealed a correlation between interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR). Using primary human fibroblasts (pHLFs) murine...

The interaction of recent orographic uplift and climate heterogeneity acted as a key role in the East Himalaya-Hengduan Mountains (EHHM) has been reported many studies. However, how exactly promotes clade diversification remains poorly understood. In this study, we both used chloroplast

Airtraq® laryngoscope can obviously improve laryngeal visualization and may provide a useful solution to treatment of patients with difficult exposure (DLE) under conventional suspension in phonomicrosurgery.In phonomicrosurgery, otolaryngologists inevitably encounter DLE. Attempts have yielded important advances, but the prevalence DLE yet remains persistent. To overcome this problem, study applied perform phonomicrosurgery combined video system. The aim is, thus, explore clinical...

Aspect Sentiment Triplet Extraction (ASTE) is widely used in various applications. However, existing ASTE datasets are limited their ability to represent real-world scenarios, hindering the advancement of research this area. In paper, we introduce a new dataset, named DMASTE, which manually annotated better fit scenarios by providing more diverse and realistic reviews for task. The dataset includes lengths, expressions, aspect types, domains than datasets. We conduct extensive experiments on...

Chromatin remodeling plays an important role in regulating gene transcription, which chromatin complex is a crucial aspect. Brg1/Brm-associated factor 60c (BAF60c) subunit forms bridge between complexes and transcription factors mammals; hence, it has received extensive attention. However, the roles of BAF60c fish remain largely unexplored. In this study, we identified BAF60c-interacting proteins by using HIS-pull-down LC-MS/MS analysis fish. Subsequently, RNA-seq was performed to identify...

<p dir="ltr"><a href="" target="_blank"><b>Abstract</b></a></p><p dir="ltr">Diabetic encephalopathy (DE) is a severe complication of the central nervous system associated with diabetes. This research aims to investigate regulatory role mammalian target rapamycin (mTOR) on nuclear factor kappa-B (NF-κB) in mice DE, and neuroprotective effect therapeutic mechanisms luteolin, natural flavonoid compound anti-inflammatory, antioxidant, properties. The...

Diabetic encephalopathy (DE) is a severe complication of the central nervous system associated with diabetes. In this study, we investigated regulatory role mammalian target rapamycin (mTOR) on nuclear factor κB (NF-κB) in mice DE, and neuroprotective effect therapeutic mechanisms luteolin, natural flavonoid compound anti-inflammatory, antioxidant, properties. The results indicated that treatment luteolin improved degree cognitive impairment DE. It also decreased levels phosphorylated mTOR,...

The chemokine receptors CCR1 and CCR5 display overlapping expression patterns ligand dependency. Here we find that activation of CCR5, not CCR1, is dependent on N-terminal receptor O-glycosylation. Release from O-glycosylation dependency obtained by increasing N-terminus acidity to the level CCR1. Ligand drastically improves in absence glycosaminoglycans (GAGs). activity at both boosted positively charged/basic peptides shown interact with acidic N-termini. We propose an inherent low rely...

Abstract Background Sevoflurane preconditioning improves brain function in MCAO rats, and there are several methods for determining appropriate concentration time windows preconditioning. This study investigated the protective effects with a single sevoflurane at different concentrations on rats. Methods Adult Sprague-dawley rats were randomly assigned to 14 groups. The group inhaled 0.5 MAC, 1.0 1.3 MAC sevoflurane, respectively 3 h, then models established 6 12 24 48 h. sham groups...

Objective To investigate the effects of propranolol on proliferation and apoptosis cultured infantile hemangioma-derived endothelial cells (HemECs).Methods The hemangioma tissue harvested from female patients was using explants adherent method.The digested to become single cell suspension.The HemECs were labeled purified by fluorescent-activated sorting (FACS).The viability measured counting kit-8 assay (CCK-8).Cell studied calculating BrdU incorporation rate.The induction determined flow...

Objective To explore the PI3K/Akt signaling pathway associated with apoptosis of hemangioma-derived endothelial cell (HemEC).Methods HemECs and human umbilical vein cells (HUVECs) were subject to serum starvation for 12-48 hours.Cell was measured by flow cytometry annexin-V-fluorescein isothiocyanate/propidium iodide,Hoechst 33342 terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining.The expression vascular growth factor (VEGF) activation Akt detected.And...

The interaction of recent orographic uplift and climate heterogeneity acted as a key role in the East Himalaya-Hengduan Mountains (EHHM) has been reported many studies. However, how exactly promotes clade diversification remains poorly understood. Here, we both studied genetic structure chloroplast trnT-trnF region 11 nuclear microsatellite loci Hippophae gyantsensis examined what geological barriers or ecological factors play spatial structure. results showed that this species had strong...

Objective To investigate the expression of Oct-4 in neuroblastoma.Methods The 39 neuroblastoma tissues and paracancerous was determined by real-time PCR Western blot.The relationship between clinical data also analyzed.Results level preoperative significantly higher than that tissues(P＜0.05),and its stage Ⅲ-Ⅳ Ⅰ Ⅱ.In tumors Ⅲ-Ⅳ,the decreased subgroup with chemotherapy when compared without chemotherapy.Conclusions correlates positively progression neuroblastoma.The can be inhibited...