A5100361540- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- Ion Transport and Channel Regulation
- interferon and immune responses
- Physiological and biochemical adaptations
- Chemokine receptors and signaling
- Circular RNAs in diseases
- Chromatin Remodeling and Cancer
Institute of Tibetan Plateau Research
2024-2025
University of Chinese Academy of Sciences
2024-2025
Chinese Academy of Sciences
2025
Chinese People's Armed Police Force
2014-2024
JiangSu Armed Police General Hospital
2024
Wuhan University of Science and Technology
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Jimo District Qingdao Hospital of Traditional Chinese Medicine
2024
Guangdong Pharmaceutical University
2024
Abstract Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages flowering plants. We hypothesize convergent evolution protein sequence and temporal gene expression underpins the independent emergences CAM from C 3 photosynthesis. To test this hypothesis, we generate de novo genome assembly genome-wide transcript data for Kalanchoë fedtschenkoi , an obligate species within core eudicots with...
Lots of studies have shown that cyclin disorders can promote tumor development. This study aims to investigate the biological function and molecular mechanism CCNB2 in lung adenocarcinoma (LUAD).LUAD data were downloaded from GEO database TCGA-LUAD database. Differential analysis was conducted find differentially expressed miRNAs mRNAs, while targeted prediction done for access potential target mRNAs. Gene expression level detected by qRT-PCR Western blot human LUAD cell lines A-427, A549,...
Tubulointerstitial fibrosis is the final common pathway for all kidney diseases leading to chronic disease. TGF-β/Smad signaling plays a key role in renal fibrosis. Previous studies have revealed that rhubarb extracts attenuated increase of TGF-β1 CKD rats. To gain an in-depth insight into mechanism anti-fibrotic activities extracts, we investigated influence on and metabolome rat model with adenine-induced tubulointerstitial nephropathy. Male Sprague Dawley rats were divided 4 groups,...
Polyamines have been reported to be involved in grain filling and they might contribute the construction of heat resistance some cereals. In this study, hybrid rice 'YLY 689' was used explore possible effects exogenous spermidine (Spd) on seed quality under high temperature during stage. Rice spikes were treated with Spd or its synthesis inhibitor cyclohexylamine (CHA) after pollination, then plants transferred 40 °C for 5-day treatment. The results showed that, compared control temperature,...
Delayed neurocognitive recovery (dNCR) is a prevalent perioperative neurological complication in older patients and has common characteristics such as acute cognitive dysfunction, impaired memory, inattention. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are enclosed by lipid bilayer contain proteins, DNA, miRNA, other components, which important mediators of intercellular communication. It been reported that could play an role the treatment neurodegenerative diseases, nerve injury,...
Convergent evolution is an important sector of evolutionary biology. High-altitude environments are one the extreme for animals, especially in Qinghai Tibet Plateau, driving inquiry whether, under broader phylogeny, high-altitude factors drive convergent Artiodactyla and Perissodactyla gut microbiomes. Therefore, we profiled microbiome at high low altitudes using 16S rRNA gene sequencing. According to cluster analyses, compositions were not grouped together far from those low-altitude...
We generated the first comprehensive view of RNA viral auxiliary metabolic genes (AMGs), expanding known functional type AMGs by 75%. viruses encode a remarkably high diversity AMGs, spanning 25 distinct categories. Most these are linked to environmental regulation and genetic information processing, with fewer associated nutrient cycling. Additionally, carrying capable infecting both eukaryotes prokaryotes, may acquire from organisms beyond their predicted host range. Viruses most abundant...
The dynamics of DNA hybridization is very important in DNA-programmable nanoparticle crystallization. Here, coarse-grained molecular utilized to explore the structural and dynamic properties hybridizations for a self-complementary DNA-directed self-assembly system. hexagonal close-packed (HCP) face-centered cubic (FCC) ordered structures are identified systems different grafted chains per nanoparticle, which good agreement with experimental results. Most importantly, crystallization...
Aquaporins (AQPs) are major intrinsic proteins that facilitate the transport of water, small solutes, and ions through membranes. In mammals, classical aquaporin AQP4 plays a central role in preservation nervous system (CNS) water homeostasis. Litopenaeus vannamei is typical euryhaline crustacean, with salinity tolerance range 0.5–78. Compared to those reared at low-salinity, shrimps cultured high-salinity have better taste qualities, but slower growth, lower product yield, higher mortality....
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water and small solutes across cell membranes. These vital for maintaining homeostasis in living organisms. In mammals, thirteen aquaporins have been characterized, but crustaceans, especially penaeid shrimp, diversity, structure, substrate specificity these channel largely unknown. We here presented three types AQPs from Litopenaeus vannamei based on genome transcriptome sequencing. Phylogenetic analysis...
Voltage-gated Kv1.1/Kvbeta1.1 A-type channels, as a natural complex, can switch from fast to slow inactivation under oxidation/reduction conditions. The mode-switching of inactivation, which is mediated by cysteine residue in the ball domain Kvbeta1.1 N terminus, regulate membrane electrical excitability. In present study, we identified mechanism whereby channels regulated calcium influx. rise intracellular calcium, due either influx extracellular space or release stores, eliminates induced...
Natural products are a major source of biological molecules. The 3-methylfuran scaffold is found in variety plant secondary metabolite chemical elicitors that confer host-plant resistance against insect pests. Herein, the diversity-oriented synthesis natural-product-like library reported, which core fused an angular attachment to six common natural product scaffolds—coumarin, chalcone, flavone, flavonol, isoflavone and isoquinolinone. structural diversity this assessed computationally using...
This study explores the impact of pyroptosis-related genes (PRG) on prognosis liver cancer (LC).
RNA viruses play an important role in regulating their host and global biogeochemical cycling, auxiliary metabolic genes (AMGs) are one of the main pathways by which regulate hosts metabolism. However, AMGs encoded largely unexplored. Here, we annotated viral genomes identified from recently published virome datasets. We found 274 243 genomes, accounts for only 0.008% all 3,216,257 investigated. These span 25 functional categories, most prevalent being translation, energy metabolism,...