A5088475635- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Sinusitis and nasal conditions
- Facial Nerve Paralysis Treatment and Research
- Voice and Speech Disorders
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Tracheal and airway disorders
- Ear and Head Tumors
- Biochemical Analysis and Sensing Techniques
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Neuroscience and Neural Engineering
- Phonetics and Phonology Research
- Electrochemical Analysis and Applications
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Vitamin C and Antioxidants Research
- Surgical Simulation and Training
- MicroRNA in disease regulation
- Transcranial Magnetic Stimulation Studies
- Ion channel regulation and function
Peking University
2015-2024
Peking University Third Hospital
2015-2024
Xilinx (United States)
2022
Beijing National Laboratory for Molecular Sciences
2008-2021
Chinese Academy of Sciences
2007-2021
Google (United States)
2015
Institute of Chemistry
2008
National Natural Science Foundation of China
2008
Peking University People's Hospital
2008
Air Force Institute of Aviation Medicine Affiliated Hospital
2007
Probing chemical information in the central nervous system is essential for understanding molecular mechanism of brain function. Electrochemistry with tissue-implantable carbon fiber electrodes (CFEs) provides a powerful tool monitoring dynamics neurochemicals subsecond time scale; however, implantation CFEs into tissue immediately causes nonspecific adsorption proteins on electrode surfaces. This process can dramatically impact performance electrochemical method terms reduced sensitivity...
Cytotoxic edema is the initial and most important step in sequence that almost inevitably leads to brain damage. Exploring neurochemical disturbances this process of great significance providing a measurable biological parameter for signaling specific pathological conditions. Here, we present an electrochemical system pinpoints critical involved cytotoxic edema. Specially, report molecularly tailored brain-implantable ascorbate sensor (CFEAA2.0) featuring excellent selectivity spatiotemporal...
Abstract Background Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still lack of effective drugs treat the disease. Recently, novel biological therapies, such as mesenchymal stem cells (MSCs) their products, namely, exosomes, are showing promising therapeutic potential due low immunogenicity, few ethical concerns, easy accessibility. Nevertheless, precise mechanisms underlying effects MSC-derived exosomes remain unclear. Results...
Although in stapes surgery successful hearing improvement may be achieved the majority of patients, unsatisfactory closure air-bone gap can recorded. One many reasons for unexpected failures insufficient crimping a prosthesis onto incus. The objectives study were to assess amount sound transmission loss response quality and identify required loop attachment pattern obtain good results.Experimental.A temporal bone model was developed measure properties between incus on 17 fresh human bones....
Neuronal communication relies on cooperation between the chemical and electrical patterns of neurons. Thus, techniques for illustrating linkage neurochemical events action potentials with high temporal spatial resolution is imperative to gain a comprehensive understanding intricacies brain function. Herein, we integrate galvanic redox potentiometry (GRP) electrophysiological recording onto 16-site Au microelectrode array (MEA), one which indicating ascorbate concentration while others...
Background: Automatic segmentation of temporal bone computed tomography (CT) images is fundamental to image-guided otologic surgery and the intelligent analysis CT in field otology. This study was conducted test a convolutional neural network (CNN) model that can automatically segment almost all anatomy structures adult pediatric images. Methods: A dataset comprising 80 annotated volumes collected, which 40 samples were obtained from adults children. further 60 (30 30 children) used train...
Segmentation of important structures in temporal bone CT is the basis image-guided otologic surgery. Manual segmentation time- consuming and laborious. We assessed feasibility generalization ability a proposed deep learning model for automated critical scans.Thirty-nine volumes including 58 ears were divided into normal (n = 20) abnormal groups 38). Ossicular chain disruption 10), facial nerve covering vestibular window Mondini dysplasia 18) included group. All nerves, auditory ossicles,...
Development of new principles and techniques at the single-cell level is significantly important since cells as basic units living organisms always bear large heterogeneity. Herein, we demonstrate a electrochemical principle for analysis based on an ion current blockage orifice nanopipette, defined resistance cytometry. The amplitude frequency transients show strong dependence size concentration cells, which could be used in situ cell sizing counting. This technique shows good ability to...
Objective To document isolated round window atresia and to discuss its impact on current theories of inner ear function. Patients Study Design Retrospective analysis suggesting an autosomal dominant inheritance pattern review concepts cochlear macromechanics. Setting Tertiary referral center. Results The unexpected finding in two female patients the same family was confirmed intraoperatively as well postoperatively using high-resolution computed tomography. audiograms literature highlight a...
Vitamin C (Vc) plays a pivotal role in series of pathological processes, such as tumors, immune diseases, and neurological disorders. However, its therapeutic potential for tinnitus management remains unclear. In this study, we find that Vc relieves noise-exposed rats. the 7-day therapy groups, spontaneous firing rate (SFR) increases from 1.17 ± 0.10 Hz to 1.77 0.15 after noise exposure. effectively reduces elevated SFR 0.99 0.07 0.55 0.05 at different doses. The glutamate level auditory...
The primary purpose of the present study was to investigate relationship between postimplant electrically evoked auditory brainstem response (EABR) measures (wave V threshold, wave latency, input-output functions) and performance speech intelligibility outcomes measured using parental rating scales, such as Categories Auditory Performance (CAP; Archbold, Lutman, & Marshall, 1995) Speech Intelligibility Rating scale (SIR; Allen, Nikolopoulos, Dyar, O'Donoghue, 2001), respectively. secondary...
As one of the most important neurochemicals in biological systems, ascorbate plays vital roles many physiological and pathological processes. In order to understand process tinnitus, this study demonstrates an vivo method for real time monitoring changes level cochlear perilymph guinea pigs during acute period tinnitus induced by local microinfusion salicylate with carbon fiber microelectrodes (CFMEs) modified multiwalled nanotubes (MWNTs). To accomplish electrochemical microenvironment...
Objective: To investigate the prevalence, severity of hearing disorders and demographics people with based on whole population in Jilin, Guangdong, Shannxi Gansu provinces China. Methods: According to " WHO Ear Hearing Disorders Survey Protocol" , 144 clusters were chosen probability proportional sampling(PPS) method from four covering 194, 688, 061 residents. Audiological test, otological examination questionnaire surveying conducted for all samples August, 2014 September, 2015. The...
Abstract Background The demand for assessing health-related quality of life (HRQoL) in chronic otitis media (COM) is increasing globally. currently available Chinese-language patient-reported outcome measurement (PROM) specific COM includes merely a limited range related symptoms and dimensions. Hence, this study, we aim to translate, culturally adapt, validate the Zurich Chronic Middle Ear Inventory (ZCMEI-21) Chinese, enable comprehensive evaluation patients’ subjective health COM. Methods...
Conclusion: Diazepam can reduce the excitability of lateral amygdala and eventually suppress auditory cortex in rats following salicylate treatment, indicating regulating effect to tinnitus procedure.Objective: To study spontaneous firing rates (SFR) regulated by diazepam rat model induced sodium salicylate.Materials methods: This first created a modal salicylate, recorded SFR both amygdala. Then was intraperitoneally injected changes recorded. Finally, microinjected on recorded.Results:...
Auditory deprivation affects normal age-related changes in the central auditory maturation. Cochlear implants (CIs) have already become best treatment strategy for severe to profound hearing impairment. However, it is still hard evaluate speech-language outcomes of pediatric CI recipients because hearing-impaired children with limited abilities. The cortical evoked potential (CAEP) provides a window into development pathways. This preliminary study aimed at assessing electrophysical...
Abstract Background: Without timely and effective rehabilitation, hearing loss may profoundly affect human life quality. China has a large population of hearing-impaired individuals, which imposes heavy health burden on society. Moreover, this is projected to increase rapidly owing China’s aging Methods: We used data from population-representative epidemiological investigation ear diseases in four Chinese provinces. estimated the national prevalence using multiple linear regression age-group...
This study demonstrates the application of an OECS as <italic>in vivo</italic> method to investigate dynamic change ascorbate in olfactory bulb rats during acute period dysfunction.
Image-guided cochlear implant surgery is expected to reduce volume of mastoidectomy, accelerate recovery, and improve safety. The purpose this study was investigate the safety effectiveness image-guided by a non-invasive registration method, in cadaveric study. We developed visual positioning frame that can utilize maxillary dentition as tool completed tunnels experiment on 5 cadaver specimens (8 cases total). accuracy entry point target were 0.471 ± 0.276 mm 0.671 0.268 mm, respectively....