A5089055582- Congenital gastrointestinal and neural anomalies
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Foreign Body Medical Cases
- Neuroblastoma Research and Treatments
- Advanced Proteomics Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Intestinal Malrotation and Obstruction Disorders
- Congenital Diaphragmatic Hernia Studies
- Pelvic floor disorders treatments
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Airway Management and Intubation Techniques
- Diverticular Disease and Complications
- Soft tissue tumor case studies
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Vascular Malformations and Hemangiomas
- Epigenetics and DNA Methylation
First Affiliated Hospital of Zhengzhou University
2016-2025
Kunming Medical University
2021-2025
Henan University of Science and Technology
2025
Yan'an Hospital Affiliated To Kunming Medical University
2021-2025
Shanghai University
2023
Creative Commons
2019
Zhengzhou University
2009-2015
Abstract Background Autophagy is an intracellular process through which components are recycled in response to nutrient or growth factor deficiency maintain homeostasis. We identified the peptide autophagy-related cancer-suppressing (ARCSP), a potential antitumor that disrupts homeostasis by blocking autophagic flux and causes cytotoxic death. Methods The proliferative ability of ARCSP-treated cervical cancer cells was examined CCK8, EdU, colony formation assays. TUNEL assay used detect...
Necrotizing enterocolitis (NEC) is a potentially fatal illness in premature neonates. Tumor necrosis factor-α (TNF-α) and autophagy are associated with the pathogenesis of NEC. This study aimed to explore whether TNF-α might regulate apoptosis neonatal NEC model cells IEC-6 via regulation autophagy. rat was induced by hand feeding exposure asphyxia/cold-stress for histologic examination. The vitro (IEC-6/NEC cells) established stimulating intestinal epithelial cell line lipopolysaccharide...
Thyroid carcinoma is the most common endocrine malignancy and a cancer among malignancies of head neck. Noninvasive convenient biomarkers for diagnosis papillary thyroid (PTC) as early possible remain an urgent need. The aim this study was to discover identify potential protein PTC specifically.Two hundred twenty four (224) serum samples with 108 116 controls were randomly divided into training set blind testing set. Serum proteomic profiles analyzed using SELDI-TOF-MS. Candidate purified by...
Objective Enhanced recovery after surgery (ERAS) protocols help optimize inpatient care and minimize discomfort. This study was performed to explore the safety, feasibility, clinical social value of ERAS in pediatric gastrointestinal surgery. Methods included all children (n = 125) who underwent appendectomy, pyloromyotomy, transabdominal Soave’s procedure, Meckel’s diverticulum resection, or reduction intussusception our institution from January September 2018. We compared surgical outcomes...
This study aimed to evaluate the pharmacokinetics and tissue distribution of albendazole (ABZ) its three metabolites─albendazole sulfoxide (ABZSO), sulfone (ABZSO2), albendazole-2-aminosulfone (ABZ-2-NH2–SO2)─in Yellow River carp (Cyprinus carpio haematopterus) reared at 17.2 ± 1.1 °C after single oral administration 12 mg/kg body weight (BW) ABZ. The concentrations ABZ metabolites in different samples were measured using high performance liquid chromatography (HPLC). Pharmacokinetic...
Abstract Hirschsprung’s disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR demonstrated increased predictive performance for risk in Europeans using genetic score, there remains notable gap knowledge regarding Chinese populations. We conducted whole exome sequencing case cohort...
Hyperglycemia and poststroke immunosuppression can lead to a decline in immune function, resulting an increased incidence of infectious events. The relationship between the glucose-to-lymphocyte ratio (GLR), novel indicator, stroke-associated pneumonia (SAP) remains unclear. objective this study is investigate early predictive value GLR context SAP. A retrospective analysis was conducted on acute stroke patients admitted Department Neurology at First Affiliated Hospital Kunming Medical...
Abstract Purpose To describe the incidence and management of gastrointestinal tract Buckyball magnets ingestions in a multicenter Chinese pediatric patient population, discuss preventive measures. Methods Medical records 74 patients from 9 large hospitals during past 10 years, who were diagnosed as buckyball ingestion got invasive treatment, retrospectively studied. The follow-up was through telephone outpatient service to estimate post-surgery condition. Information collection online...
Abstract Background The molecular mechanisms of osteosarcoma (OS) are complex. In this study, we focused on the functions melanoma cell adhesion molecule (MCAM), methyltransferase 3 (METTL3) and insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) in OS development. Methods qRT-PCR assay western blot were performed to determine expression MCAM, METTL3, IGF2BP1 YY1. MTT colony formation conducted assess proliferation. Cell apoptosis, invasion migration evaluated by flow cytometry...
Women with triple-negative breast cancer (TNBC) have poor prognosis because of the aggressive nature tumor, delayed diagnosis and non-specific symptoms in early stages. Identification novel specific TNBC serum biomarkers for screening therapeutic purposes therefore remains an urgent clinical requirement.We obtained samples from a total 380 recruited individuals split into mining testing sets, aim reliable protein non-TNBC (NTNBC) sera. Samples were assessed using mass spectrometry, followed...
Background As an end stoma, Santulli enterostomy provides early restoration of intestinal continuity without formal laparotomy. Short amputation the common limb enables closure on a side to restore anatomic sacrificing valuable intestine; additionally, procedure is simple and safe. Most newborns who require might benefit from enterostomy; however, several pediatric surgeons lack information regarding this procedure. Therefore, we have reviewed our experience about explore advantages...
Wilms’ tumor is one of the most common malignant tumors observed in children, and its early diagnosis important for late-stage treatment prognosis. We previously screened identified protein markers tumor; however, these lacked specificity, some were associated with inflammation. In current study, serum samples from children compared those healthy controls patients systemic inflammatory response syndrome (SIRS). After exclusion factors inflammation, specific identified. comparing peak values...
Dysregulation of long non-coding RNAs (lncRNAs) has been known to be relevant the progression human cancers, including neuroblastoma (NB). Small nucleolar RNA host gene 7 (SNHG7) identified as an oncogene in a series cancers. The purpose present study was investigate function and underlying mechanism SNHG7 NB progression. qRT-PCR used determine levels SNHG7, cyclin D1 (CCND1), miR-323a-5p miR-342-5p. Cell migration invasion abilities were detected by transwell assays. Glucose consumption...
We evaluated the clinical features of neonatal Hirschsprung's disease (HD)-associated bowel perforation (perforated HD) and investigated risk factors related to it.We retrospectively collected data neonates (<1 month age) with perforated HD from multicenters in China January 2006 December 2019. A total 142 patients (6.7%) were enrolled study. 1:2 matching method was used compare information without during period. The for identified using univariate multivariate logistic regression...
The prevalence of malnutrition is unknown in patients with Hirschsprung disease. Undernutrition associated poor clinical outcomes. This study aims to describe the nutrition status among disease at admission.We retrospectively used data from children admitted three pediatric surgery centers China January 2016 December 2020. weight-for-age z scores (WAZ), height-for-age (HAZ), and body mass index-for-age (BAZ) were calculated as reference for risk according World Health Organization child...
Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, mechanisms underlying damaged cartilage induced by not been elucidated. Twenty-four SD rats were randomly divided into and control groups. In group, 12 administered 4% absolute ethanol gavage, in (100 ng/g, BW/day) gavage. After sacrificed, knee joints collected, RNA was extracted using TRIzol reagent for sequencing (RNA-seq). Differentially expressed mRNA identified based on p < 0.05 | log2...
Background: Cholangitis is common in patients with biliary atresia following Kasai portoenterostomy (KPE). The prompt use of empiric antibiotics essential due to the lack identified microorganisms. authors aimed validate a severity grading system guide antibiotic therapy management post-KPE cholangitis. Materials and methods: This multicenter, prospective, randomized, open-label study recruited cholangitis was conducted from January 2018 December 2019. On admission, were categorized into...
Abstract Kaposiform haemangioendothelioma (KHE) and tufted angioma (TA) are rare vascular tumors that can cause life‐threatening Kasabach–Merritt phenomenon. No evidence‐based treatment strategies have yet been established, its management is still a challenge. The purpose of this multicenter prospective randomized controlled study was to evaluate compare the efficacy corticosteroid vincristine (VCR) in KHE TA. All patients with KHE/TA who met diagnostic criteria were consecutively recruited....