A5100328973- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Airway Management and Intubation Techniques
- Neurological Disorders and Treatments
- Pain Management and Treatment
- Macrophage Migration Inhibitory Factor
- Respiratory Support and Mechanisms
- Gastrointestinal disorders and treatments
- Cardiac Arrest and Resuscitation
- Education and Professional Development
- Pharmacological Effects of Natural Compounds
- IL-33, ST2, and ILC Pathways
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Myofascial pain diagnosis and treatment
- Congenital Anomalies and Fetal Surgery
- Pediatric health and respiratory diseases
- Thermal Regulation in Medicine
- Pain Mechanisms and Treatments
- Phytochemistry and biological activity of medicinal plants
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Nanjing Medical University
2023
Children's Hospital of Fudan University
2012-2020
Hartford Hospital
2019
Fudan University
2012-2015
Boston Children's Hospital
2014
Background Poststroke depression and anxiety, independent predictor of poor functional outcomes, are common in the acute phase stroke. Up to now, there is no fast-onset antidepressive anxiolytic agents suitable for management ZL006-05, a dual-target analgesic we developed, dissociates nitric oxide synthase from postsynaptic density-95 while potentiates α2-containing γ-aminobutyric acid type A receptor. This study aims determine whether ZL006-05 can be used as an antistroke agent with...
Summary Background Postoperative hypothermia in the postanesthesia care unit ( PACU ) neonates and infants is a well‐known serious complication as it can increase risk of blood loss, wound infections, cardiac arrhythmias. Aim To identify an effective rewarming method for China with postoperative hypothermia, open‐label, randomized, controlled study was performed to compare effects three different methods. Methods Neonates (<1 year) admitted after surgery between June 2011 November 2012...
Children with severe obstructive sleep apnea syndrome (OSAS) are more sensitive to opioids. Identifying such children and reducing or even eliminating opioids necessary but difficult. We have previously shown that patients intraoperative fentanyl require less postoperatively.The objective of this study was evaluate the performance a postinduction test in identifying syndrome.A prospective, observational, assessor-blinded carried out 104 assessed undergoing elective adenotonsillectomy....
Abstract Prenatal propofol exposure induced neurotoxicity in the developing brains and led to persistent learning deficits offspring. Our goal was use zebrafish explore whether decline memory correlated with inhibition of neuronal growth after exposure. Zebrafish embryos at 6 hours postfertilization (hpf) were exposed control or 1, 2 4 μg/mL until 48 hpf. Spontaneous locomotor activity swimming behavior response dark‐to‐light photoperiod stimulation studied larvae days (dpf). The...
Acceleromyography used to monitor the neuromuscular transmission function is available in infants and children. However, information on so-called staircase phenomenon during baseline stabilization period this population limited. Our objective was assess characteristics of such acceleromyography.Thirty were divided into three groups: group A (aged 1-5 months, n = 10), B 6-11 C 12-24 10). Anesthesia induced maintained without blocking agents. Patients received a supramaximal stimulus followed...
Inflammatory pain and neuropathic are major health issues that represent considerable social economic burden worldwide. In this study we investigated the potential of obtusifolin gluco-obtusifolin, two anthraquinones found in seeds widely used traditional Chinese medical botanical Cassia obtusifolia, to reduce inflammatory pain. The analgesic effects gluco-obtusifolin were evaluated by mice formalin test complete Freund’s adjuvant (CFA)-induced nociceptive behaviors rats. Chronic...
We investigated the minimal alveolar concentration (MAC) of sevoflurane associated with occurrence isoelectric electroencephalogram in 50% children under steady-state conditions (MAC IE). The MAC IE was determined 100% oxygen and addition nitrous oxide or after injection fentanyl.Seventy-two (ASA I II, age 3-8 years) undergoing elective surgery were allocated to one three groups: (group O2 ), N2 O), a bolus 3 μg/kg fentanyl FENTANYL). state EEG considered as significant when burst...
目的对比分析芬太尼试验与简明儿童OSAS量表（简称量表）识别重度阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome，OSAS）的价值，寻找一种简便可靠的方法指导扁桃体伴腺样体切除术患儿围术期阿片类药物的使用。 方法前瞻性选择复旦大学附属儿科医院2018年6—11月期间择期行扁桃体伴腺样体切除术并于术前完成多导睡眠监测（polysomnography，PSG）的连续病例102例，由不知晓PSG诊断结果的医生指导监护人于术前填写中文版筛查量表；由不知晓PSG以及量表诊断结果的麻醉医生于麻醉诱导后进行芬太尼试验。对照PSG诊断结果，分析芬太尼试验诊断重度OSAS的价值，并与量表进行比较。 结果102例手术患儿中46例为重度OSAS，量表诊断32例，灵敏度69.6%，特异度76.8%，阳性预测值71.1%，阴性预测值75.4%，准确度73.5%；芬太尼试验诊断40例，灵敏度87.0%，特异度87.5%，阳性预测值85.1%，阴性预测值89.1%，准确度87.3%，各项指标差异均有统计学意义（P...