A5091564417- Intraperitoneal and Appendiceal Malignancies
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Respiratory Support and Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Pelvic and Acetabular Injuries
- Mesenchymal stem cell research
- Mechanical Circulatory Support Devices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Abdominal Trauma and Injuries
- Appendicitis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Abdominal Surgery and Complications
- Intestinal and Peritoneal Adhesions
- Climate Change Communication and Perception
- IL-33, ST2, and ILC Pathways
The University of Texas MD Anderson Cancer Center
2024-2025
University of Limerick
2024
Brown University
2015-2022
Rhode Island Hospital
2016-2022
Providence College
2022
Lifespan
2018
Stony Brook University Hospital
2012-2013
The University of Texas Southwestern Medical Center
1969
Abstract Indirect acute respiratory distress syndrome (iARDS) is caused by a nonpulmonary inflammatory process resulting from insults such as sepsis. Neutrophils are thought to play significant role in mediating ARDS, with the development of iARDS being characterized dysregulation and recruitment activated neutrophils into lung. Recently, novel mechanism microbial killing was identified through formation neutrophil extracellular traps (NETs). NETs composed large webs decondensed chromatin...
Deficiency of the co-inhibitory receptor, Programmed cell death receptor (PD)-1, provides a survival benefit in our murine shock/sepsis model for development indirect acute respiratory distress syndrome (iARDS). Further, clinical significance, patients that develop ARDS express increased PD-1 on their blood leukocytes. While expression and its regulatory role have been associated with mainly T-cell responses, contribution primary ligand, PD-L1, broadly expressed non-immune cells such as lung...
<p>Supplementary Figures</p>
<div>AbstractPurpose:<p>Appendiceal adenocarcinoma is a rare malignancy with distinct histopathologic subtypes and natural history metastasis primarily limited to the peritoneum. Little known about molecular pathogenesis of appendiceal relative common tumors.</p>Experimental Design:<p>We analyzed data for patients within Guardant Health database appendix cancer (<i>n</i> = 718). We then identified at our institution (from October 2004–September 2022) whom...
<p>Appendiceal Adenocarcinoma Circulating Mutational Profiles</p>
This study sets out to establish the comparative contribution of PD-L1 expression by pulmonary endothelial cells (ECs) and/or epithelial (EpiCs) development indirect acute lung injury (iALI) taking advantage observation that treatment with naked siRNA intratracheal delivery in mice primarily affects EpiCs, but not ECs, while intravenous liposomal-encapsulated largely targets vascular ECs including lung, EpiCs. We showed using a mouse model iALI [induced hemorrhagic shock followed septic...
We have shown that invariant natural killer T (iNKT) cells mediate sepsis-induced end-organ changes and immune responses, including macrophage bacterial phagocytosis, a finding regulated by the check point protein program cell death receptor-1 (PD-1). Furthermore, PD-1 mediates mortality in both adult neonatal murine sepsis as well surgical patients. Given our previous findings, we hypothesize iNKT will also modulate survival, this effect is part through PD-1. utilized polymicrobial...
Therapeutic interventions to treat acute lung injury (ALI) remain largely limited lung-protective strategies, as a real molecular pathophysiologically driven therapeutic intervention has yet become available. While we have previously documented the expression of herpes virus entry mediator (HVEM) on leukocytes septic mice and critically ill patients, its functional role in shock/sepsis-induced ALI not been studied. Inasmuch, murine model indirect (iALI) was induced by hemorrhagic shock (HEM)...
Abstract Background Given the complementary roles of health professionals and journalists in communicating risks to patients public, there have been calls for physicians work with improve quality information received by public. Understanding preferences medical journalism students way which are communicated their understanding words used describe risk is an important first step inform interdisciplinary learning. Methods Medical ( n = 203) completed online survey where they were given...
The liver is an organ that, when dysfunctional in a septic patient, strongly associated with morbidity and mortality. Understanding the pathophysiology of failure during sepsis may lead to improved diagnostics potential therapeutic targets. Historically, programmed cell death receptor (PD) ligand 1 (PD-L1) has been considered primary for its checkpoint molecule counterpart, PD-1, PD-L2 rarely immunopathological spotlight. PD-1 PD-L1 contribute dysfunction murine cecal ligation puncture (CLP)...