A5082003047- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
- Immune cells in cancer
- Retinal Diseases and Treatments
- Cellular transport and secretion
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Eicosanoids and Hypertension Pharmacology
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Inflammatory Biomarkers in Disease Prognosis
- Dementia and Cognitive Impairment Research
- Inflammation biomarkers and pathways
- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Cancer Mechanisms and Therapy
- Skin Protection and Aging
- Neurological Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
Washington University in St. Louis
2023-2025
Nanjing University of Finance and Economics
2025
First Affiliated Hospital of Chengdu Medical College
2024-2025
Chengdu Medical College
2024
University of South China
2024
Fudan University
2024
Case Western Reserve University
2019-2022
University School
2019-2022
Diabetic retinopathy (DR) is a neurovascular complication of diabetes. Recent investigations have suggested that early degeneration the neuroretina may occur prior to appearance microvascular changes; however, mechanisms underlying this neurodegeneration been elusive. Microglia are predominant resident immune cell in retina and adopt dynamic roles disease. Here, we show ablation retinal microglia ameliorates visual dysfunction type I diabetes mouse model. We also provide evidence enhanced...
Introduction The systemic immune-inflammation index (SII) has been proven to predict the outcome in cancerous and non-cancerous diseases. We aimed investigate relationship between SII other inflammatory markers prognosis patients receiving intravenous thrombolysis (IVT). Methods Acute ischemic stroke treated with IVT were collected retrospectively. SII, neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) constructed based on admission blood testing. Favorable was defined as...
The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally derived RORγt+ Tregs (pTregs), which prevent intolerance inflammatory bowel disease. Recent studies suggested that antigen-presenting cells (APCs), encompass rare dendritic cell (DC) subsets type 3 innate lymphoid (ILC3s), are key pTreg induction. Here, we developed a mouse with reduced APCs by deleting specific cis-regulatory element of Rorc encoding RORγt. Single-cell RNA...
Elucidating signal transduction mechanisms of innate immune pathways is essential to defining how they elicit distinct cellular responses. Toll-like receptors (TLR) through their cytoplasmic TIR domains which bind other domain-containing adaptors. dSARM/SARM1 one such domain adaptor best known for its role as the central axon degeneration trigger after injury. In degeneration, SARM1’s have been assigned unique functions: ARM auto-inhibitory, SAM-SAM interactions mediate multimerization, and...
Abstract Synapses are highly specialized for neurotransmitter signaling, yet activity-dependent growth factor release also plays critical roles at synapses. While efficient signaling relies on precise apposition of sites and receptors, molecular mechanisms enabling high-fidelity within the synaptic microenvironment remain obscure. Here we show that auxiliary calcium channel subunit α 2 δ-3 promotes function an autocrine Bone Morphogenetic Protein (BMP) pathway Drosophila neuromuscular...
Continuous electroencephalogram (cEEG) plays a crucial role in monitoring and postoperative evaluation of critical patients with extensive EEG abnormalities. Recently, the temporal variability dynamic resting-state functional connectivity has emerged as novel approach to understanding pathophysiological mechanisms underlying diseases. However, little is known about connections admitted neurology intensive care unit (NICU). Furthermore, considering emerging field network physiology that...
Abstract: Tripartite-motif protein family member 65 (TRIM65) belongs to the tripartite motif (TRIM) family. Its typical structure consists of RING, B-Box motif, and coiled-coil domains, which are highly conserved at N-terminus variable SPRY domain C-terminus. TRIM65 is an E3 ubiquitin ligase that participates in physiological pathological processes through ubiquitination pathway, including intracellular signal transduction, degradation, cell proliferation, apoptosis, carcinogenesis,...
ABSTRACT Background & Aims Perianal fistulizing Crohn’s disease (PCD) is a common and debilitating complication with elusive pathophysiology. We examined mucosal cells from patients PCD related conditions using multi-omics approach. Methods recruited (n = 24), CD without perianal (NPCD, n 10), idiopathic fistulas (IPF, 29). Biopsies were taken fistula tracts, opening, rectal mucosa. Single-cell RNA-sequencing (scRNA-seq), mass cytometry (CyTOF), spatial transcriptomics (ST),...
Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age future risk of was not systematically examined. To investigate relationship (both subjective/perceived objective) impairment and/or risk. The study included 195,329 participants (age ≥ 60 y) from UK Biobank (UKB) with self-perceived 612 Nutrition Health Aging Population in China Project (NHAPC) 56 objective assessment age. Cox proportional hazards model used to...