A5005704011- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Laser Applications in Dentistry and Medicine
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- Animal Virus Infections Studies
- Circadian rhythm and melatonin
- Viral gastroenteritis research and epidemiology
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Nitric Oxide and Endothelin Effects
- Healthcare and Venom Research
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- Myxozoan Parasites in Aquatic Species
- Genetics, Aging, and Longevity in Model Organisms
- Medicinal Plants and Bioactive Compounds
- Virus-based gene therapy research
- Invertebrate Immune Response Mechanisms
- Alzheimer's disease research and treatments
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Qilu Hospital of Shandong University
2022-2024
Sun Yat-sen University
2020-2022
Sun Yat-sen Memorial Hospital
2020-2022
Jimei University
2022
Qingdao University
2017
Affiliated Hospital of Qingdao University
2017
Abstract Air pollution has greatly increased the risk of idiopathic pulmonary fibrosis (IPF). Circular RNAs (circRNAs) have been found to play a significant role in advancement IPF, but there is limited evidence correlation between circRNAs and lung epithelial cells (LECs) IPF. This research aimed explore influence on regulation EMT progression LECs, with objective elucidating its mechanism establishing association Our results suggested that downregulation circGRHPR peripheral blood clinical...
After being discovered for the first time in China 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become prevalent strain of PRRSV certain regions China. Our previous study showed that reduced Ingelvac PRRS MLV vaccination dosages against NADC30-like CF had a better protection effect than normal dosage. However, protective is unclear. Therefore, this compared effectiveness 0.1 1 infection using commercial vaccines, MLV, which been widely utilized...
Perioperative neurocognitive disorder (PND) leads to progressive deterioration of cognitive function, especially in aged patients. Demyelination is closely associated with dysfunction. However, the relationship between PND and demyelination remains unclear. Here we showed that was related pathogenesis PND. Clemastine, an antihistamine potency remyelination, predicted have a potential therapeutic effect on by next-generation sequencing bioinformatics our previous study. In present study, it...
Perioperative neurocognitive disorder (PND) is a serious nervous system complication characterized by progressive cognitive impairment, especially in geriatric population. However, the neuropathogenesis of PND complex, and there are no approved disease-modifying therapeutic options. Mitochondrial dysfunction has been demonstrated to contribute occurrence development PND. Transcranial near-infrared (tNIR) light treatment helps improve mitochondrial enhance cognition, but its effect on remains...
To identify the molecular mechanisms and novel therapeutic agents of late-onset Alzheimer's disease (AD), we performed integrative network analysis using multiple transcriptomic profiles human brains. With hypothesis that AD pathology involves whole cerebrum, first identified co-expressed modules across cerebral regions aging brain. Among them, two (M3 M8) consisting 1,429 protein-coding genes were significantly enriched with AD-correlated genes. Differential expression microarray, bulk...
Postoperative neurocognitive disorder (PND) is one of the most common postoperative neurological complications in aged patients, characterized by mental disorder, anxiety, personality changes, and impaired memory. At present, molecular mechanism PND remains largely unclear, ideal biomarker for clinical diagnosis prognosis are lacking. Circular RNA (circRNA) microRNA (miRNA), as unique non-coding RNAs, affecting regulation miRNAs on genes further intervening progression diseases through...
Background Postoperative neurocognitive disorder (PND) is a common central nervous system (CNS) complication that might increase the morbidity and mortality of elderly patients after anesthesia/surgery. Neuroinflammation, oxidative stress, synaptic dysfunction are closely related to cognitive dysfunction, an important clinical feature PND. Transcranial near-infrared laser (TNIL) regarded as effective treatment for cognitive-related diseases by improving mitochondrial function alleviating...
Focal adhesion kinase (FAK) has long been considered to be a key regulator of growth factor receptor- and integrin-mediated signals, with pivotal roles in tumor cells through its activity scaffolding function. Increased FAK expression observed tumors various origins is often associated poor prognosis. However, there have no studies on the aberrant thymic epithelial date. The aim present study was evaluate explore prognostic significance FAK. investigated 100 formalin-fixed, paraffin-embedded...
Pseudomonas plecoglossicida is responsible for visceral white spot disease in economically valuable marine fish such as Larimichthys crocea and Epinephelus coioides . Based on RNA sequencing, we previously showed that P. fliS gene expression significantly up-regulated E. spleens during infection. Here, to explore the role of this pathogenicity, interference (RNAi) was performed silence , mutant with best silencing efficiency (89%) chosen further studies. Results attenuated motility,...
Valvular heart disease accounts for up to 20% of cardiac surgery in the United States. Computer simulation "virtual interventions" may inform optimal valve repair a given patient prior intervention. However, there is paucity methods noninvasively determine vivo mechanical properties tissue from clinically acquired 3D images, limiting accuracy computer prediction and translational potential silico repairs. Here, we propose ADEPT, A noninvasive method Determining Elastic Properties Tissue,...
At present, the NADC30-like strain has become prevalent of PRRSV in China. Many studies have found that existing commercial vaccines are ineffective or provide only limited protection. No study investigated cross-protection different dosages MLV against PRRSV. Therefore, this assessed effectiveness various a infection using vaccines, Ingelvac PRRS MLV, which been widely utilized
Prolonged exposure to general anesthesia (GA) results in long-lasting cognitive impairment, especially during critical stages of brain development. An exaggerated neuroinflammation induced by is generally considered be a key cause impairment.Postnatal day 7 (PND 7) mice were exposed GA isoflurane inhalation for 6 h or mock anesthesia. Disodium cromoglycate (DSCG) was intraperitoneally injected daily 2 weeks, beginning from 30 min before The post-anesthesia evaluation included behavioral...
Abstract BackgroundExposure to sunlight may decrease the risk of developing Alzheimer’s disease (AD). However, wavelength light with this therapeutic effect and related mechanism remain elusive. MethodWe evaluated behaviors AD-like mice treated by different wavelengths showed that far infrared (FIR) (λ = 3 - 25 μm) had a great potential in ameliorating cognition dysfunction. ResultsFIR treatment promoted recruitment microglia Aβ plaques, enhanced phagocytosis decreased neuroinflammatory...
Abstract Background: Exposure to sunlight may decrease the risk of developing Alzheimer’s disease (AD). However, wavelength light with this therapeutic effect and related mechanism remain elusive. Failure clear amyloid-β (Aβ), main component amyloid plaque, has been considered as a key cause development AD. As resident immune cell in brain, microglia is able carry out Aβ clearance. We hypothesize that improves AD-related cognitive dysfunction beneficial be via clearance by microglia. Method:...
Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients with acquired congenital cardiac disease. Image-derived computational modeling atrioventricular valves has advanced substantially over the last decade holds particular promise to inform repair small heterogeneous populations which are less likely be optimized through empiric clinical application. While an abundance biomechanics studies have investigated mitral tricuspid disease adults, few...