Jamey Sultan
A5050949501- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Mechanisms of cancer metastasis
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
University of North Carolina Health Care
2019
National Institutes of Health
2018-2019
Northwestern University
2019
University of Kansas
2019
Leidos (United States)
2019
Leidos Biomedical Research Inc. (United States)
2019
Tufts University
2019
National Center for Advancing Translational Sciences
2015-2018
A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis vivo.
Abstract The perinucleolar compartment (PNC) is a nuclear body that forms specifically in highly malignant cancer cells. PNC prevalence shown to reflect metastatic potential of cells from solid tissue origins. A high-content screen was performed identify small molecules reduce prevalence. Medicinal chemistry optimizations confirmed hits yield metarrestin, having 95% oral bioavailability and disassembly IC50 between 100 400 nM across multiple cell lines. Metarrestin inhibits soft agar growth...