A5103257546- MicroRNA in disease regulation
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Anomaly Detection Techniques and Applications
- Plant Gene Expression Analysis
- Microbial Inactivation Methods
- Metabolomics and Mass Spectrometry Studies
- Hydrocarbon exploration and reservoir analysis
- Biological Research and Disease Studies
- Psoriasis: Treatment and Pathogenesis
- Genetics, Aging, and Longevity in Model Organisms
- Sentiment Analysis and Opinion Mining
- Hydraulic Fracturing and Reservoir Analysis
- High voltage insulation and dielectric phenomena
- E-commerce and Technology Innovations
- Planarian Biology and Electrostimulation
- Biochemical and Molecular Research
- Postharvest Quality and Shelf Life Management
- Electromagnetic Compatibility and Measurements
- Hepatocellular Carcinoma Treatment and Prognosis
- Network Security and Intrusion Detection
- Heat shock proteins research
- Thermal Analysis in Power Transmission
- Enhanced Oil Recovery Techniques
- Food composition and properties
Guilin Medical University
2024-2025
Florida State University
2024
China Agricultural University
2024
Fujian Agriculture and Forestry University
2024
Taiyuan Heavy Industry (China)
2024
Zhengzhou University
2021-2024
Fujian Academy of Agricultural Sciences
2024
Rice Research Institute
2024
Shandong University
2019-2022
Shandong Provincial QianFoShan Hospital
2019-2022
Although thousands of genes have been identified or cloned in rice (Oryza sativa) the last two decades, majority them only separately characterized specific varieties single-gene modified backgrounds, thus limiting their practical application. We developed an optimized multiplex genome editing (MGE) toolbox that can efficiently assemble and stably express up to twelve sgRNA targets a single plant expression vector. In this study, we established MGE-based Rapid Directional Improvement (MRDI)...
In recent years, photodynamic therapy (PDT) has gradually attracted the attention of researchers due to its therapeutic potential for treating malignant tumors. Hypericin (HC) is anticipated enhance effect on tumors as an efficient photosensitizer (PS) PDT. However, role and mechanism PDT in hepatocellular carcinoma (HCC) remain unclear. this study, we investigated efficacy hypericin nanoparticles (HC-NPs)-associated (HC-NPs-PDT) HCC explore anti-HCC both vitro vivo. Cellular molecular...
Recently, industrial gas flows have been produced from the vertical well acidification tests of Wells JS1 and YH1 in Section 1 Maokou Formation southern region eastern Sichuan Province, China. This result proves that contains a group excellent source rocks gas-bearing reservoirs. In this study, pore structure characteristics primary causes nanopore were explored using scanning electron microscopy, X-ray diffraction total rocks, organic carbon, liquid nitrogen adsorption, other experimental...
Prostate cancer (PCa) is one of the most common cancers in males and particularly tends to metastasize bone. Currently, metastatic bone disease incurable, new therapies need be developed. Our study aims determine role miR-127-3p PCa metastasis The results demonstrate that markedly reduced metastasis-positive tissues relative metastasis-negative tissues. Furthermore, overexpressing inhibits cell invasion migration vitro by targeting proteasome β-subunit PSMB5. Moreover, CCCTC-binding factor...
Acetylation plays an important role in regulating the chaperone activity of heat shock protein 90 (Hsp90) during malignant transformation through stabilization and conformational maturation oncogenic proteins. However, functional acetylation sites, potential anticancer drug targets, are still emerging. We found that at K292 Hsp90α is critical for development treatment breast cancer. not only augments affinity Hsp90 to ATP , cochaperones, client proteins but it also promotes cancer cell...
Prostate cancer (PC) is the second leading cause of cancer-related death among men worldwide. Downregulation miR-485-3p has been revealed to participate in tumorigenesis and progression many types cancer. However, clinical biological role PC remains largely unknown.The expression was analyzed published databases detected our samples cell lines by RT-qPCR assay. CCK8, transwell invasion migration, colony formation assays were performed investigate function miR-485-3p. Bioinformatical...
Although radical surgical resection is the most effective treatment for hepatocellular carcinoma (HCC), high rate of postoperative recurrence remains a major challenge, especially in patients with alpha-fetoprotein (AFP)-negative HCC who lack biomarkers surveillance. Emerging radiomics can reveal subtle structural changes tumors by analyzing preoperative contrast-enhanced computer tomography (CECT) imaging data and may provide new ways to predict early (recurrence within 2 years)...
Postharvest ethylene accumulation and lignification are significant issues affecting the storage quality of fresh faba beans, resulting in rapid decline. However, there is still a lack effective preservation methods to preserve beans during storage. This study aimed investigate regulation using high-efficiency remover (HEER), examining physiological responses, key enzyme activities, transcriptomic changes. Results showed that HEER treatment inhibited lignification, reducing it by 45%...
Oxygen plays a central role in biomolecular structures and functions, with 17O NMR emerging as powerful tool for elucidating properties. However, the low natural abundance of NMR‐active isotope, (0.0373%), presents significant hurdle to its widespread application. Here, we introduce rapid cost‐effective approach amino acid‐specific 17O‐labeling recombinant proteins. Using common bacterial expression system 30‐minute synthesis protocol 17O‐labeled acids via mechanochemical saponification,...
Abstract Tricarboxylic acid cycle is an important pathway and the metabolites of tricarboxylic cycle, simple organic acids, play roles in many physiological processes. The new conditions high performance liquid chromatography (HPLC) with improved separation selectivity were developed optimized by choosing suitable store solvent, methanol, which can catalyze reaction, aldol condensation, facilitate formation compound to improve simultaneous detection nine including lactic acid, pyruvic citric...
Aiming at the problem of single waveform medium frequency and low voltage AC electric field in inhibiting tumor growth. In this paper, pulsed with flexible adjustable parameters rich content was selected to explore whether could effectively inhibit growth cells from simulation experiment for first time. The dielectric model cell established by COMSOL software analyze distribution inside under action field. results showed that intensity significantly higher than normal intermediate field,...
Anomaly detection within dynamic networks holds significant relevance in fields such as cybersecurity, e-commerce, and social media. Recent methods employing deep learning concentrate on alterations node-dependent substructures networks, yielding superior outcomes compared to graph embedding-based techniques. Nevertheless, these grapple with two primary problems network anomaly detection: the disruption caused by relevant neighbors during node sampling inadequate integration of...