A5081213474- Polysaccharides and Plant Cell Walls
- Natural product bioactivities and synthesis
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nanocomposite Films for Food Packaging
- Pluripotent Stem Cells Research
- Microbial Metabolites in Food Biotechnology
- Cancer Treatment and Pharmacology
- Postharvest Quality and Shelf Life Management
- Genomics, phytochemicals, and oxidative stress
- Chemotherapy-induced organ toxicity mitigation
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Cancer, Stress, Anesthesia, and Immune Response
- Seaweed-derived Bioactive Compounds
- RNA modifications and cancer
- HVDC Systems and Fault Protection
- Antimicrobial Peptides and Activities
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Hepatitis Viruses Studies and Epidemiology
- Ferroptosis and cancer prognosis
- Phytochemical Studies and Bioactivities
- Liver physiology and pathology
Nanchang University
2018-2024
First Affiliated Hospital of Nanchang University
2023-2024
State Key Laboratory of Food Science and Technology
2021-2023
Hunan University of Traditional Chinese Medicine
2021
Northeast Forestry University
2020
Numerous kinds of bioactive polysaccharides are identified as having intestinal immunomodulatory activity; however, the ways in which different work differ. Therefore, we selected nine representative polysaccharides, including xanthan gum, inulin, guar arabinogalactan, carrageenan, glucomannan, araboxylan, xylan, and fucoidan, compared their mechanisms. A cyclophosphamide (CTX)-induced immunosuppressed model was used this experiment, effects these on number T cells mucosa, expression...
Acute liver failure (ALF) is an inflammation-mediated hepatocyte death process associated with ferroptosis. Avicularin (AL), a Chinese herbal medicine, exerts anti-inflammatory and antioxidative effects. However, the protective effect of AL mechanism on ALF have not been reported. Our in vivo results suggest that significantly alleviated lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced hepatic pathological injury, enzymes, inflammatory cytokines, reactive oxygen species iron levels...
Recurrent liver cancer after surgery is often treated with radiotherapy, which induces damage. It has been documented that activation of the TGF-β and NF-κB signaling pathways plays important roles in irradiation-induced pathologies. However, significance mTOR remains undefined irradiation exposure. In present study, we investigated effects inhibiting mTORC1 on irradiated livers. Male C57BL/6J mice were acutely exposed to 8.0 Gy X-ray total body subsequently rapamycin. The rapamycin...
Abstract Background Metagenomic next-generation sequencing (mNGS) is an emerging technique for the clinical diagnosis of infectious disease that has rarely been used ascites infection in patients with cirrhosis. This study compared mNGS detection conventional culture methods on etiological cirrhotic and evaluated effect mNGS. Methods A total 109 due to cirrhosis were included study. We by analyzing diagnostic results, pathogen species effects. The influence management was also evaluated....
Background and Purpose Damage to intestinal epithelial cells mucosa limits the effectiveness of several anti‐cancer chemotherapeutic agents but underlying mechanism (s) remain unknown. Little is known how enteric nervous system regulates proliferation, differentiation, impairment, regeneration stem cells. Here we have investigated effects isoprenaline on damaged induced by treatments in mice. Experimental Approach The inhibiting sympathetic parasympathetic nerves were examined male C57BL/6J...
Irradiation-induced kidney damage is inevitable during radiotherapeutic practice, which limits effective radiotherapy doses on tumor treatment. In the present study, role of mTOR complex 1 (mTORC1) signaling was investigated in irradiation-induced renal injuries.Mice were exposed to 8.0-Gy X-ray total body irradiation and subsequently treated with rapamycin. Changes morphology assessed by hematoxylin eosin staining. Expression pS6 CD133 detected via immunostaining. Cellular apoptosis...
Abstract Epigenetic modifications, especially N 6 -methyladenosine (m A) modification, play a key role in tumor microenvironment (TME) infiltration. However, the regulatory of m A modification TME lung adenocarcinoma (LUAD) remains unclear. total 2506 patients with LUAD were included analysis and divided into different groups according to distinct modification-related patterns based on 23 regulators. comprehensive was performed explore infiltration patterns. Principal component obtain Ascore...