A5025229067- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- HVDC Systems and Fault Protection
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Iron Metabolism and Disorders
- Autophagy in Disease and Therapy
Sun Yat-sen University
2023
Eighth Affiliated Hospital of Sun Yat-sen University
2023
As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. However, primary mechanisms regulating osteogenic differentiation controversial. Composed of multiple constituent enhancers, super enhancers (SEs) powerful cis-regulatory elements that identify genes ensure sequential differentiation. The present study demonstrated SEs were MSC osteogenesis involved osteoporosis Through integrated analysis, we identified most...
Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by secreting monocyte chemoattractant protein 1 (MCP1). However, the regulatory mechanisms MCP1 secretion in MSCs are still unclear. Recently, N6-methyladenosine (m6A) modification was reported be involved functional regulation MSCs. In this study, we demonstrated that methyltransferase-like 16 (METTL16) negatively regulated expression...
Iron deficiency (ID) is a widespread condition concomitant with disease and results in systemic dysfunction of target tissues including skeletal muscle. Activated by ID, ferritinophagy recently found type selective autophagy, which plays an important role various physiological pathological conditions. In this study, we demonstrated that ID-mediated impeded myogenic differentiation. Mechanistically, induced RNF20 degradation through the autophagy-lysosomal pathway then negatively regulated...