A5025650018- Retinal Development and Disorders
- Connexins and lens biology
- Zebrafish Biomedical Research Applications
- Cancer, Hypoxia, and Metabolism
- Congenital heart defects research
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Photoreceptor and optogenetics research
- Estrogen and related hormone effects
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Cells and Metastasis
- Photochromic and Fluorescence Chemistry
- Natural product bioactivities and synthesis
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Physiological and biochemical adaptations
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Coronary Artery Anomalies
Bengbu Medical College
2023
Huazhong University of Science and Technology
2018-2019
Ministry of Education of the People's Republic of China
2018
Mutations in human prominin 1 (PROM1), encoding a transmembrane glycoprotein localized mainly to plasma membrane protrusions, have been reported cause retinitis pigmentosa, macular degeneration, and cone–rod dystrophy. Although the structural role of PROM1 outer-segment (OS) morphogenesis has demonstrated Prom1-knockout mouse, mechanisms underlying these complex disease phenotypes remain unclear. Here, we utilized zebrafish model further investigate PROM1's retina. The Prom1 orthologs...
The proper development of atrioventricular (AV) valves is critical for heart morphogenesis and the formation cardiac conduction system. Defects in AV valve are most common type congenital defect. Cardiac troponin I ( ctnni), a structural regulatory protein involved muscle contraction, subunit complex, but functions molecular mechanisms ctnni during early remain unclear. We created knockout zebrafish model which 1b tnni1b) Tnni-HC, craniofacial) was deleted using clustered regularly...
Background . The ocular inflammatory microenvironment has been reported to be closely associated with the occurrence and progression of highly myopic cataract (HMC). Long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) could alter biological properties mammalian cells by modulating expression mediators; therefore, it may contribute development HMC. Objective To investigate function MALAT1 in response, proliferation, migration, epithelial‐mesenchymal transition...
Cancer stem cells (CSCs) are major drivers of metastasis, drug resistance and recurrence in numerous cancers. However, critical factors that can modulate CSC stemness have not been clearly identified. Nuclear receptor subfamily 2 group E member 3 (<em>nr2e3</em>) expression has previously reported to be positively associated with sensitivity favorable clinical outcomes patients estrogen (ER)<sup>+</sup> breast cancer. This suggests <em>nr2e3</em> may inversely this type tumor cells. The...