A5052568547- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Child and Adolescent Health
- demographic modeling and climate adaptation
- Air Quality and Health Impacts
- IL-33, ST2, and ILC Pathways
- Dialysis and Renal Disease Management
- Thyroid Cancer Diagnosis and Treatment
- Radioactivity and Radon Measurements
- Adolescent and Pediatric Healthcare
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Lymphoma Diagnosis and Treatment
- Health disparities and outcomes
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
Guangzhou University of Chinese Medicine
2015-2025
Guangzhou Medical University
2024-2025
Army Medical University
2021-2022
Southwest Hospital
2021-2022
Fudan University
2016-2022
Hubei University of Medicine
2012-2022
Shanghai Ninth People's Hospital
2022
Shanghai Jiao Tong University
2022
Weatherford College
2021
Minhang District Central Hospital
2021
Chemotherapy is one of the most important strategies for glioma treatment. However, "impermeability" blood-brain barrier (BBB) impedes chemotherapeutics from entering brain, thereby rendering very few drugs suitable therapy, letting alone application a combination chemotherapeutics. Thereby, there pressing need to overcome obstacles. A dual-targeting strategy was developed by magnetic guidance and transferrin receptor-binding peptide T7-mediated active targeting delivery. The T7-modified...
The neuroprotective effect of ceria nanoparticles in the context brain disorders has been explained by their antioxidant effect. However, in-depth mechanism remains unknown. As resident immune cells brain, microglia exert a variety functional reprogramming termed as polarization response to stress stimuli. Herein, custom-made were developed and found scavenge multiple reactive oxygen species with extremely high efficiency. These drove microglial from pro-inflammatory phenotype an...
Inflammatory bowel disease (IBD) is an incurable of the gastrointestinal tract with a lack effective therapeutic strategies. The proinflammatory microenvironment plays significant role in both amplifying and sustaining inflammation during IBD progression. Herein, biocompatible drug-free ceria nanoparticles (CeNP-PEG) regenerable scavenging activities against multiple reactive oxygen species (ROS) were developed. CeNP-PEG exerted effect dextran sulfate sodium (DSS)-induced colitis murine...
Abstract MicroRNAs (miRNA) have been shown to be associated with tumor diagnosis, prognosis, and therapeutic response. MiR-328-3p plays a significant role in breast cancer growth; however, its actual function how it modulates specific biological functions is poorly understood. Here, miR-328-3p was significantly downregulated cancer, especially patients metastasis. Mitochondrial carnitine palmitoyl transferase 1a (CPT1A) downstream target gene the miR-328-3p-regulated pathway. Furthermore,...
Renal fibrosis is the common outcome in all progressive forms of chronic kidney disease. Unfortunately, pathogenesis renal remains largely unexplored, among which metabolic reprogramming plays an extremely crucial role evolution fibrosis. Ceria nanoparticles (CeNP-PEG) with strong ROS scavenging and anti-inflammatory activities have been applied for mitochondrial oxidative stress inflammatory diseases. The present study aims to determine whether CeNP-PEG has therapeutic value fibrosis.The...
A 63-year-old male patient presented with a four-month history of vision loss in the left eye and blurred right eye, cause which was not immediately apparent. The initially diagnosed uveitis both eyes at Department Ophthalmology. Subsequently, as central nervous system lymphoma Brain Medicine initiated systemic treatment. However, due to progressive deterioration visual function, further evaluation performed Based on results vitreous fluid cytokine test, intraocular eyes. Intravitreal...
Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims develop novel composite material combining enzymatic nanoparticles nerve growth factor (NGF) modulate immune microenvironment enhance SCI repair. CeMn (NP) NP-polyethylene glycol (PEG) nanozymes were synthesized via sol–gel reaction DSPE-mPEG modification. Transmission Electron Microscopy,...
Malignant gliomas are the most common primary brain tumors and associated with aggressive growth, high morbidity, mortality. Aberrant mesenchymal-epithelial transition factor (MET) activation occurs in approximately 30% of glioma patients correlates poor prognosis, elevated invasion, increased drug resistance. Therefore, MET has emerged as an attractive target for therapy. In this study, we developed a novel nanoinhibitor by conjugating MET-targeting cMBP peptides on G4 dendrimer. Compared...
Renal fibrosis (RF) predisposes patients to an increased risk of progressive chronic kidney disease, and effective treatments remain elusive. Mesenchymal stem cell (MSC)-derived exosomes are considered a new treatment for tissue damage. Our study aimed investigate the in vitro effects bone marrow MSC-derived (BM-MSC-Exs) on transforming growth factor-β1 (TGF-β1)-induced renal tubular epithelial cells (HK-2 cells) associated mechanisms. Herein, we found BM-MSC-Exs could inhibit TGF-β1-induced...
A novel hyaluronic acid (HA)-based strategy for the green synthesis of AgNP was developed, in which HA used as both reducer and stabilizer, HA-modified can target CD44-overexpressed cancer cells improved therapy.
UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel filters with high safety and efficacy urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for filter development, due their tunable optical, electrical, photoelectric properties by precise controlled synthesis.Herein, four zinc-based MOFs various bandgap energies were chose investigate optical behaviors evaluate possibility as sunscreens. Zeolitic imidazolate...
Albumin-based drug delivery has been demonstrated to be useful for achieving improved cancer therapy, largely due its passive target toward tumor via the enhanced permeability and retention effect increased demand albumin by cells as source of energy amino acids. However, lacks not only active mechanism overcome cell membrane barrier, but also ability penetrate into tissues. Herein, a cell-penetrating albumin-based strategy was developed, in which peptide chemically conjugated order enhance...
A protease-responsive probe is developed based on a molecular dynamics simulation method for the rational design of hairpin "turn" structure peptides. The Förster resonance energy transfer (FRET)-based used in vivo detection legumain, protease overexpressed inflammation-related carcinogenesis, providing potential early cancer and tumor imaging, helpful information better understanding legumain's role tumorigenesis.
Abstract The neuroprotective effect of ceria nanoparticles in the context brain disorders has been explained by their antioxidant effect. However, in‐depth mechanism remains unknown. As resident immune cells brain, microglia exert a variety functional reprogramming termed as polarization response to stress stimuli. Herein, custom‐made were developed and found scavenge multiple reactive oxygen species with extremely high efficiency. These drove microglial from pro‐inflammatory phenotype an...
Abstract MicroRNAs (miRNAs) play critical roles in carcinogenesis and development of cancers. In this study, we analyzed the eccentrically expressed miRNAs head neck squamous cell carcinoma (HNSCC) tissues based on miRNA-Seq data HNSCC patients available Cancer Genome Atlas database. Aberrant expression 2589 was detected (1128 downregulated 1461 upregulated). The differential levels were further validated by analysis 25 samples paired control compared with Gene Expression Omnibus database to...
BackgroundThe infiltrative nature and lymphatic metastasis of head neck squamous cell carcinoma (HNSCC) are the main reasons leading to its poor prognosis.MethodsA multimodal surface-enhanced resonance Raman spectroscopy (SERRS) magnetic (MR) nanoprobe, in which paramagnetic chelators heptamethine cyanine-based reporter molecules were functionalized on a gold nanostar (AuS) surface was developed. Preoperative MRI intraoperative SERRS-guided surgery performed rabbits bearing VX2 tumours...
Background: Hepatocellular Carcinoma (HCC) is a primary liver cancer with high mortality. Paeoniflorin pinane monoterpene picroside anti-tumor effect isolated from Chinese peony root and white root. Objective: The study was conducted to investigate the underlying mechanism of (PF) regulating progression via 5-hydroxytryptamine receptor 1D (5-HT1D). Methods: HepG2 SMMC-7721 hepatoma cells were treated different concentrations PF (0, 5, 10, 20 μM). Cell proliferation, apoptosis, migration,...
As an empirical case, this study selected the illegal production process incidents of rabies and DPT (Diphtheria, Pertussis, Tetanus) vaccines by Changchun Longevity Biotechnology Co., Ltd., which occurred in July 2018. Based on four factors involved spread public opinion, health emergency, netizen, network media, government, Brusselator model, entropy method were applied to calculate positive negative entropy—to verify whether Internet opinion system is a dissipative structure. This...