A5049918202- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Ferroptosis and cancer prognosis
- Dendrimers and Hyperbranched Polymers
- Cancer, Hypoxia, and Metabolism
- Polymer Surface Interaction Studies
- Nanocluster Synthesis and Applications
- X-ray Diffraction in Crystallography
- Advanced Drug Delivery Systems
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Metal complexes synthesis and properties
- Radiation Therapy and Dosimetry
- Cancer Research and Treatments
- Crystallization and Solubility Studies
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Protein Tyrosine Phosphatases
- CAR-T cell therapy research
Zhujiang Hospital
2023-2024
Southern Medical University
2021-2024
University of Chicago
2015-2021
Chinese Academy of Sciences
2011-2014
Shanghai Institute of Materia Medica
2012-2014
Shenyang Pharmaceutical University
2010-2014
Abstract Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate only 12% for patients metastatic disease. Checkpoint inhibitors, such as antibodies inhibiting PD-1/PD-L1 axis, are among most promising immunotherapies advanced colon cancer, but their durable response remains low. We herein report use immunogenic nanoparticles to augment antitumour efficacy PD-L1 antibody-mediated immunotherapy. Nanoscale coordination polymer (NCP) core-shell carry oxaliplatin...
An effective, nontoxic, tumor-specific immunotherapy is the ultimate goal in battle against cancer, especially metastatic disease. Checkpoint blockade-based immunotherapies have been shown to be extraordinarily effective but benefit only minority of patients whose tumors pre-infiltrated by T cells. Here, we show that Zn-pyrophosphate (ZnP) nanoparticles loaded with photosensitizer pyrolipid (ZnP@pyro) can kill tumor cells upon irradiation light directly inducing apoptosis and/or necrosis and...
The combination of a chemotherapeutic drug with multidrug resistance (MDR) modulator has emerged as promising strategy for treating MDR cancer. To ensure two drugs could be simultaneously delivered to tumor region at the optimum ratio, and released earlier faster than inactivate P-glycoprotein (P-gp) subsequently inhibit pumping out drug, smart pH-sensitive polymeric micelles system high loading precise ratio was designed prepared by conjugating doxorubicin (DOX) poly(styrene-co-maleic...
We report the design of a phosphorescence/fluorescence dual-emissive nanoscale metal–organic framework (NMOF), R-UiO, as an intracellular oxygen (O2) sensor. R-UiO contains Pt(II)-porphyrin ligand O2-sensitive probe and Rhodamine-B isothiocyanate O2-insensitive reference probe. It exhibits good crystallinity, high stability, excellent ratiometric luminescence response to O2 partial pressure. In vitro experiments confirmed applicability biosensor. This work is first NMOF-based sensor should...
Selective delivery of photosensitizers to mitochondria cancer cells can enhance the efficacy photodynamic therapy (PDT). Though cationic Ru-based accumulate in mitochondria, they require excitation with less penetrating short-wavelength photons, limiting their application PDT. We recently discovered X-ray based by nanoscale metal-organic frameworks (nMOFs) via enhancing radiotherapy (RT) and enabling radiodynamic (RDT). Herein we report Hf-DBB-Ru as a mitochondria-targeted nMOF for RT-RDT....
Abstract Nanoparticles can potentially stimulate tumour microenvironments to elicit antitumour immunity. Herein, we demonstrate effective immunotherapy of colorectal cancer via systemic delivery an immunostimulatory chemotherapeutic combination in nanoscale coordination polymer (NCP) core-shell particles. Oxaliplatin and dihydroartemesinin have contrasting physicochemical properties but strong synergy reactive oxygen species (ROS) generation anticancer activity. The combined ROS is harnessed...
To improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy efficacy of exceedingly small iron oxide nanoparticles (IO, <5 nm) for tumors via enhancing sensitivity tumor microenvironment (TME) responsiveness, inspired by molecular logic gates, a self-assembled IO with an AND gate function is designed constructed. Typically, cystamine (CA) conjugated onto end poly(2-methylthio-ethanol methacrylate) (PMEMA) to generate PMEMA-CA. The PMEMA-CA grafted surface brequinar...
We report the crystallization of homochiral polyoxometalate (POM) macroanions {CoSb6O4(H2O)3[Co(hmta)SbW8O31]3}15- (1, hmta = hexamethylenetetramine) via counter cation-mediated chiral symmetry breaking and asymmetric autocatalytic processes. In presence low Co2+ concentrations both Δ- Λ-enantiomers 1 formed in reaction, crystallizing into racemic crystal rac-1. At a high concentration, polyoxoanion enantiomers showed level recognition H-bonding interactions to crystallize enantiopure...
As a famous drug delivery system (DDS), mesoporous organosilica nanoparticles (MON) are degraded slowly in vivo and the components not useful for cell nutrition or cancer theranostics, superparamagnetic iron oxide (SPION) with low loading content (DLC). To overcome problems of MON SPION, we developed SPIONs (MSPIONs) an average diameter 70 nm pore size 3.9 nm. Sorafenib (SFN) and/or brequinar (BQR) were loaded into mesopores MSPION, generating SFN@MSPION, BQR@MSPION SFN/BQR@MSPION high DLC...
The immune response in cancer reflects a series of carefully regulated events; however, current tumor immunotherapies typically address single key aspect to enhance anti-tumor immunity. In the present study, nanoplatform (Fe3 O4 @IR820@CpG)-based immunotherapy strategy that targets multiple steps cancer-immunity cycle is developed: 1) promotes release tumor-derived proteins (TDPs), including tumor-associated antigens and pro-immunostimulatory factors), addition direct killing effect, by...
Abstract Most patients with cancer are first diagnosed at an advanced disease stage, when tumors already large and/or metastases present. This circumstance has a negative impact on the prognosis and therapeutic effect of anticancer drugs. In this study, it is demonstrated that photosensitizer chlorin e6 photochemotherapy drug mitoxantrone self‐assemble into relatively stable nanoassemblies (CM NAs) through hydrogen‐bonding effect, π–π stacking, hydrophobic interactions. Administration CM NAs...
Metastasis, the main cause of cancer related deaths, remains greatest challenge in treatment. Disulfiram (DSF), which has multi-targeted anti-tumor activity, was encapsulated into redox-sensitive shell crosslinked micelles to achieve intracellular targeted delivery and finally inhibit tumor growth metastasis. The demonstrated good stability circulation specifically released DSF under a reductive environment that mimicked conditions cells. As result, DSF-loaded (DCMs) dramatically inhibited...
Due to the ability of ovarian cancer (OCa) acquire drug resistance, it has been difficult develop efficient and safe chemotherapy for OCa. Here, we examined therapeutic use a new self-assembled core–shell nanoscale coordination polymer nanoparticle (NCP-Carbo/GMP) that delivers high loadings carboplatin (28.0 ± 2.6 wt %) gemcitabine monophosphate (8.6 1.5 %). A strong synergistic effect was observed between against platinum-resistant OCa cells, SKOV-3 A2780/CDPP, in vitro. The...
CRISPR-based gene therapy offers precise targeting and specific editing of disease-related sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant challenge for its widespread application. In this study, we design novel short peptide-conjugated bioreducible polymer named TSP