A5061206062- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hops Chemistry and Applications
- Eicosanoids and Hypertension Pharmacology
- Per- and polyfluoroalkyl substances research
- Healthcare and Venom Research
- Drug-Induced Adverse Reactions
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Eosinophilic Disorders and Syndromes
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medicinal plant effects and applications
Kyungpook National University
2017-2024
Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a natural compound derived from traditional Chinese medicinal herbs, and it known to have an anti-inflammatory effect. Here, we investigated the effect of hispidulin on immunoglobulin E (IgE)-mediated allergic responses in rat basophilic leukemia (RBL)-2H3 mast cells. When RBL-2H3 cells were sensitized with anti-dinitrophenyl (anti-DNP) IgE subsequently stimulated DNP-human serum albumin (HSA), histamine β-hexosaminidase released by...
Mast cells play a crucial role in allergic diseases via the release of inflammatory mediators, particularly histamine and pro-inflammatory cytokines. Avenanthramide (Avn) C, polyphenol found mainly oats, is known to exhibit various biological properties. In this study, we aimed evaluate effectiveness Avn C from germinated oats against mast cell-mediated inflammation. For vitro RBL-2H3, mouse bone marrow-derived rat peritoneal were used. (1-100 nM) inhibited immunoglobulin (Ig)E-stimulated...
Mast cells are major effector for allergic responses that act by releasing inflammatory mediators, such as histamine and pro-inflammatory cytokines. Accordingly, different strategies have been pursued to develop anti-allergic anti-inflammatory candidates regulating the function of mast cells. The purpose this study was determine effectiveness elaeocarpusin (EL) on cell-mediated inflammation. We isolated EL from Elaeocarpus sylvestris L. (Elaeocarpaceae), which is known possess properties....
Basophils and mast cells are characteristic effector in allergic reactions. Sargahydorquinoic acid (SHQA), a compound isolated from Sargassum serratifolium (marine alga), possesses various biochemical properties, including potent antioxidant activities. The objective of the present study was to investigate inhibitory effects SHQA on activation human basophilic KU812F induced by phorbol myristate acetate A23187 (PMACI), calcium ionophore. Furthermore, we confirmed rat leukemia (RBL)-2H3 48/80...
Mast cells are effector that induce allergic inflammation by secreting inflammatory mediators. Gomisin M2 (G.M2) is a lignan isolated from Schisandra chinensis (Turcz.) Baill., exhibiting anti-cancer activities. We aimed to investigate the anti-allergic effects and underlying mechanism of G.M2 in mast cell-mediated inflammation. For vitro study, we used mouse bone marrow-derived cells, RBL-2H3, rat peritoneal cells. inhibited cell degranulation upon immunoglobulin E (IgE) stimulation...
Background: As the number of allergic disease increases, studies to identify new treatments take on urgency. Epigallocatechin gallate (EGCG), a major component green tea, has been shown possess wide range pharmacological properties, including anti-inflammation and anti-viral infection. In previous study, gallic acid (GA), part EGCG, anti-allergic inflammatory effect. To improve preliminary evidence that GA allergy mitigating effect, we designed SG-SP1 based GA, aimed assess effects mast...
Polyozellus multiplex is an edible mushroom that offers beneficial pharmacological effects against intestinal inflammation and cancer. Previous studies have demonstrated polyozellin, a major component of P. multiplex, has therapeutic activities inflammation, cancer, oxidative stress-related disorders. This study aimed to determine the polyozellin on inflammatory pruritic responses, symptoms atopic dermatitis (AD), define its underlying mechanism action. Our results showed inhibited...
Context: Diospyros kaki L. (Ebenaceae) fruit is widely distributed in Asia and known to exert anti-inflammatory antithrombotic effects.Objective: We evaluated the inhibitory effect of aqueous extract D. calyx (AEDKC) on mast cell-mediated immediate-type hypersensitivity underlying mechanism action.Materials methods: For vivo, ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) immunoglobulin (Ig) E-mediated passive cutaneous (PCA) models were used. In ASA, AEDKC (1–100 mg/kg) was...
Asthma is a complex, heterogeneous chronic inflammatory airway disease with multiple phenotypes. There has been great progress in managing asthma, but there are still unmet needs for developing uncontrolled asthma treatments. The present study aimed to determine the effectiveness of oleanolic acid acetate (OAA) from Vigna angularis against allergic inflammation and underlying mechanism action focus on mast cells.To investigate effect OAA inflammation, we used ovalbumin (OVA)-sensitized...
Cholangiocarcinoma (CCA) has a poor prognosis and high chemoresistance. Interleukin-4 receptor (IL-4R) is overexpressed in several cancer cells plays crucial role tumor progression drug resistance. IL4RPep-1, an IL-4R-binding peptide, been identified by phage display used for targeting. In this study, we exploited IL4RPep-1 to guide the tumor-specific delivery of proapoptotic peptide chemoresistant CCA, thereby inhibiting growth. Immunohistochemistry human primary CCA tissues showed that...
For centuries, natural products are regarded as vital medicines for human survival. Clematis terniflora var. mandshurica (Rupr.) Ohwi is an ingredient of the herbal medicine, Wei Ling Xian, which has been used in Chinese medicine to alleviate pain, fever, and inflammation. In particular, C. leaves have cure various inflammatory diseases, including tonsillitis, cholelithiasis, conjunctivitis. Based on these properties, this study aimed scientifically investigate anti-inflammatory effect...
More than 20% of the world’s population suffers from allergic diseases, including asthma, rhinitis, and atopic dermatitis that severely reduce patient’s quality life. The treatment allergy has been developed, but there are still unmet needs. Ampelopsis brevipedunculata (Maxim.) Trautv. is a traditional medicinal herb with beneficial bioactivities, such as antioxidant, anti-hypertension, anti-viral, anti-mutagenic, skin liver (anti-hepatotoxic) protective actions. However, its anti-allergic...