A5100786283- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Reproductive Biology and Fertility
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Endometriosis Research and Treatment
- Palliative Care and End-of-Life Issues
- Effects of Radiation Exposure
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
Seoul National University Hospital
2023-2025
Seoul National University
2024
Ewha Womans University
2019-2022
Dongnam Institute of Radiological & Medical Sciences
2019-2021
This study aimed to identify mutation profile similarities between tissue and circulating tumor DNA (ctDNA) explore driver mutations as potential prognostic or predictive biomarkers druggable targets in patients with advanced biliary tract cancer (BTC). We prospectively enrolled 18 BTC analyzed next-generation sequencing data from 60 ctDNA samples using AlphaLiquid® 100. assay screens up 118 genes for single-nucleotide variants (SNVs) insertion deletions (INDELs), 27 copy number alterations...
To report treatment outcomes of stereotactic ablative radiation therapy (SABR) for non-spinal bone metastases in a single institution, and to compare assessments Response Evaluation Criteria Solid Tumors (RECIST) v. 1.1 the University Texas MD Anderson Cancer Center (MDA) criteria.From July 2011 January 2017, 33 patients with 38 metastatic lesions were treated using SABR. Treatment intent was categorized as follows: metastasis or oligo-metastases; oligo-progression; dominant areas...
PurposeThis study evaluated the influence of prognostic factors and whole brain radiotherapy (WBRT) on overall survival (OS) breast cancer (BC) patients with metastases (BM).Methods materialsMedical records 730 BC diagnosed BM from 2000 to 2014 at 17 institutions were retrospectively reviewed. OS was calculated diagnosis. Median follow-up duration 11.9 months (range, 0.1–126.2).ResultsMedian 15.0 (95% CI: 14.0–16.9). Patients different BC-specific graded assessment (GPA) scores showed...
PurposeThis study aimed to assess prognostic factors associated with combined hepatocellularcholangiocarcinoma (cHCC-CCA) and predict 5-year survival based on these factors. Materials MethodsPatients who underwent definitive hepatectomy from 2006 2022 at a single institution was retrospectively analyzed.Inclusion criteria involved pathologically confirmed diagnosis of cHCC-CCA. ResultsA total 80 patients diagnosed cHCC-CCA were included in the analysis.The median progression-free (PFS) 15.6...
Abstract Purpose The aim of this study was to evaluate the treatment outcomes and potential dose-response relationship stereotactic body radiation therapy (SBRT) for pulmonary metastasis sarcoma. Materials methods A retrospective review 39 patients 71 lesions treated with SBRT from two institutions performed. had oligometastatic or oligoprogressive disease, were receiving palliation. Doses 20–60 Gy delivered in 1–5 fractions. local control per tumor (LCpT) evaluated according biologically...
We evaluated the inter-physician variability in target contouring of radiotherapy for anal squamous cell carcinoma (ASCC). Clinical volume (CTV) three patients diagnosed with ASCC was delineated by seven experienced radiation oncologists from multi-institution. These were staged as pT1N1a, cT2N0, and cT4N1a, respectively, according to 8th edition American Joint Committee on Cancer staging system. Expert agreement quantified using an expectation maximization algorithm Simultaneous Truth...
Abstract Whole-genome sequencing (WGS) of human tumors and normal cells exposed to various carcinogens has revealed distinct mutational patterns that provide deep insights into the DNA damage repair processes. Although ionizing radiation (IR) is conventionally known as a strong carcinogen, its genome-wide impacts have not been comprehensively investigated at single-nucleotide level. Here, we explored landscape single-cells after exposure levels IR. On average, 1 Gy IR generated ∼16 events...
In this paper, we review the use of hypofractionated radiotherapy for gastrointestinal malignancies, focusing on primary and metastatic liver cancer, recurrent rectal cancer. Technological advancements in have facilitated direct delivery high-dose radiation to tumors, while limiting normal tissue exposure, supporting hypofractionation. Hypofractionated is particularly effective cancer where irradiation crucial achieve local control. For stereotactic body offers a promising approach...
To examine the factors associated with ovarian failure (OF) and assess effectiveness of transposition (OT) before pelvic irradiation for preserving function in patients cervical cancer (CC) undergoing hysterectomy. During 2003 to 2017, who underwent hysterectomy preservation one or both ovaries were retrospectively enrolled. Patients divided into 4 groups, depending on whether radiotherapy (RT) OT performed: group 1, RT(+) OT(+); 2, OT(−); 3, RT(−) 4, OT(−). OF was defined as serum...
We aimed to evaluate the inter-clinician variability in clinical target volume (CTV) for postoperative radiotherapy (PORT) biliary tract cancer (BTC) including extrahepatic bile duct (EBDC) and gallbladder (GBC). Nine experienced radiation oncologists delineated PORT CTVs distal EBDC (pT2N1), proximal (pT2bN1) GBC patients. The expectation maximization algorithm Simultaneous Truth Performance Level Estimation (STAPLE) was used quantify expert agreements. generated volumes with a confidence...
We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) compared their overall survival (OS) 2005 through 2014 in Korea.We retrospectively reviewed 600 BC BM diagnosed between 2014. The median follow-up duration was 12.5 months. categorized the into three groups according year when initially (group I [2005-2008], 98 patients; group II [2009-2011], 200 III [2012-2014], 302 patients).Over time, age at diagnosis increased by...
Abstract Background: To examine the factors associated with ovarian failure (OF) and assess effectiveness of transposition (OT) before pelvic irradiation for preserving function in patients cervical cancer (CC) undergoing hysterectomy. Methods: During 2003-2017, who underwent hysterectomy preservation one or both ovaries were retrospectively enrolled. Patients divided into 4 groups, depending on whether radiotherapy (RT) OT performed: group 1, RT(+) OT(+); 2, OT(-); 3, RT(-) 4, OT(-). OF was...