A5012849639- Cancer and Skin Lesions
- Neurogenetic and Muscular Disorders Research
- Genetic Neurodegenerative Diseases
- Tumors and Oncological Cases
- Genetic and rare skin diseases.
- Nonmelanoma Skin Cancer Studies
- Psoriasis: Treatment and Pathogenesis
- Neurological and metabolic disorders
- Glioma Diagnosis and Treatment
- Muscle Physiology and Disorders
- Microtubule and mitosis dynamics
- Dermatological and Skeletal Disorders
- Cutaneous lymphoproliferative disorders research
- Cancer Mechanisms and Therapy
- Dysphagia Assessment and Management
- Mesenchymal stem cell research
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Blood properties and coagulation
- S100 Proteins and Annexins
- Neuroblastoma Research and Treatments
- Chemotherapy-related skin toxicity
- RNA regulation and disease
- Alcoholism and Thiamine Deficiency
- RNA Research and Splicing
Kyungpook National University Hospital
2019-2024
Kyungpook National University
2023
Dongguk University
2019
Samsung Medical Center
2013-2018
Samsung (South Korea)
2014
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy substantial survival benefit. Recent studies on solid tumors showed that fusion genes often play driver roles and are promising targets for pharmaceutical intervention. To survey potential in GBMs, we analysed RNA-Seq data from 162 GBM patients available through The Cancer Genome Atlas (TCGA), found 3′ exons neurotrophic tyrosine kinase receptor type 1 (NTRK1, encoding TrkA) fused to 5′...
Abstract Background We evaluated the therapeutic efficacy of GC1118, a novel anti‐epidermal growth factor receptor (EGFR) monoclonal antibody, in recurrent glioblastoma (GBM) patients with EGFR amplification. Methods This study was multicenter, open‐label, single‐arm phase II trial. Recurrent GBM amplification were eligible: determined using fluorescence situ hybridization analysis when sample had both EGFR/CEP7 ratio ≥2 and tight cluster signal ≥10% recorded cells. GC1118 administered...
Neurofilament light chains (NfLs) are promising biomarkers of neuroaxonal damage in stroke patients. We investigated the correlations between NfL levels and infarct volume, initial severity, functional outcomes at discharge patients with acute ischemic stroke. prospectively included 15 first-ever 8 age- sex-matched healthy controls without other neurological disorders. Serum were measured using single-molecule array (Simoa) technique twice within 24 hours admission (NfL 1D ) on seventh...
Spinal and bulbar muscular atrophy, namely Kennedy disease, is a rare progressive neurodegenerative disorder caused by the expansion of CAG repeat in first exon androgen receptor gene on X chromosome. We assessed clinical history, laboratory findings, functional scales electrophysiological data, as well levels luteinizing hormone, follicle-stimulating hormone testosterone, 157 Korean patients with genetically confirmed spinal atrophy (mean age at data collection = 56.9 years; range 33-83...
Background: Spinal and bulbar muscular atrophy (SBMA) is an X-lined motor neuron disease characterized by progressive muscle weakness, palsy, dysphagia. Dysphagia associated with tongue which a common manifestation of SBMA. This study aimed to investigate the correlations between pressure dysphagia in patients Materials Methods: Thirty-nine genetically confirmed SBMA underwent videofluoroscopic swallowing (VFSS) assessment. Then, we analyzed maximal (MTP), oral transit time,...
Abstract Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy substantial survival benefit. Recent studies on many types solid tumors showed that fusion genes often play driver roles and are promising targets for pharmaceutical intervention. To survey potential in GBM, we analysed RNA-Seq data from 162 GBM patients available through The Cancer Genome Atlas (TCGA). From analysis, identified recurrent neurotrophic tyrosine kinase receptor type...
Nuedexta (dextromethorphan and quinidine) is an Food Drug Administration approved medication for pseudobulbar affect. Interestingly, this drug was recently reported to improve speech, swallowing, the ability handle oral secretions along with emotional lability in amyotrophic lateral sclerosis (ALS) patients bulbar symptoms. We report a Korean ALS patient whose function improved after administering 6 months, extending therapeutic choice of approach treating patients. Key Words:...
Abstract Childhood cancers are rare and clinically diverse. They typically associated with few driver mutational events than adult cancers, constituting potential targets for patient-specific precision therapy approaches. Here, we evaluated the feasibility of using a patient-derived tumor cell (PDC) based drug screening system integrated multi-omics data to achieve oncology pediatric patients. We established PDC library derived from passage-cultured cells surgically resected specimens...