A5036889472- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Spine and Intervertebral Disc Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Healthcare Education and Workforce Issues
- Gastrointestinal motility and disorders
- Esophageal Cancer Research and Treatment
- Spinal Fractures and Fixation Techniques
- Diverticular Disease and Complications
- Innovations in Medical Education
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Education and Learning Interventions
- Cancer Genomics and Diagnostics
- Educational Systems and Policies
- Respiratory and Cough-Related Research
- Liver Disease Diagnosis and Treatment
Samsung Medical Center
2012-2025
Sungkyunkwan University
2013-2025
Eulji University
2023-2024
Seoul National University Hospital
2022
Hanyang University
2015-2021
Hanyang University Guri Hospital
2020
Kangbuk Samsung Hospital
2008-2016
Creative Commons
2016
Ewha Womans University
2015
University Medical Center
2014
Glutathione peroxidase 3 (GPx3) accounts for the major antioxidant activity in plasma. Here, we demonstrate that down-regulation of GPx3 plasma obese subjects is associated with adipose dysregulation, resulting from increase inflammatory signals and oxidative stress. Although was abundantly expressed kidney, lung, tissue, observed expression reduced selectively tissue several animal models as decreasing level. Adipose greatly suppressed by prooxidative conditions such high levels TNFalpha...
Esophageal hypersensitivity is currently believed to have a crucial role in the pathogenesis of functional chest pain (FCP). The aim this study was evaluate clinical efficacy venlafaxine, serotonin-norepinephrine reuptake inhibitor (SNRI), for FCP young adult patients.Patients diagnosed with were randomized either an extended-release formulation venlafaxine (75 mg hora somni) or placebo 4 weeks. After washout period 2 weeks, patients crossed over other arm study. primary variable number >50%...
Extracellular electrical recording and studies using animal models have helped establish important concepts of human gastric physiology. Accepted standards include quiescence in the fundus, 3 cycles per minute (cpm) pacemaker activity corpus antrum, a proximal-to-distal slow wave frequency gradient. We investigated activity, contractions distribution interstitial cells Cajal (ICC) muscles. Muscles were obtained from patients undergoing resection for cancer, anatomical locations each specimen...
Epidemiologic and clinical data suggest that Helicobacter pylori infection is a contributing factor in the progression of atherosclerosis. However, specific cardiovascular disease risk factors associated with H. remain unclear. We performed cross-sectional study 37,263 consecutive healthy subjects who underwent routine health check-up. In multivariable log Poisson regression models adjusted for potential confounders, associations seropositivity higher LDL-C (relative [RR], 1.21; 95%...
Osteoporotic vertebral compression fractures (OVCF) can cause severe pain, changes in balance, gait velocity, muscle fatigue, risk of falls, and subsequent fractures. Thus, OVCF significantly lowers the individual’s health-related quality life. Additionally, may increase patient mortality rates. However, studies on post-OVCF are limited. This study aimed to evaluate after first occurrence general population using a nationwide dataset from Korean National Health Insurance System. We...
AIM:To determine the prevalence and risk factors o f w r k-r e l a t d m u s c k i n gastrointestinal endoscopists in Korea.METHODS: A survey of musculoskeletal symptoms, using self-administered questionnaire, was conducted on 55 practicing general hospitals or health promotion centers.RESULTS: Forty-nine (89.1%) reported pain at least one anatomic location 37 (67.3%)endoscopists complained rest.Twenty-six (47.3%) had severe defined as visual analogue score greater than 5.5.Factors related...
Colorectal cancers (CRCs) with microsatellite instability-high (MSI+) but without detectable germline mutation or hypermethylation in DNA mismatch repair (MMR) genes can be classified as Lynch-like syndrome (LLS). The underlying mechanism and clinical significances of LLS are largely unknown. We measured MSI MMR protein expression 4,765 consecutive CRC cases. Among these, MSI+ cases were further based on parameters, sequencing polymerase ε (POLE) δ (POLD1) promoter methylation analysis MLH1...
Primary epiploic appendagitis (PEA) is an uncommon cause of abdominal pain that occurs either from appendageal torsion or spontaneous thrombosis draining vein. frequently misdiagnosed as appendicitis diverticulitis, depending on its location.Clinical and radiologic characteristics 8 patients with PEA were retrospectively reviewed compared 18 acute diverticulitis.Patients presented lower recent onset was localized to the left (seven cases) right (one case) quadrants. Well-localized tenderness...
Barrett's esophagus (BE) is diagnosed when specialized intestinal metaplasia (SIM) detected histologically in endoscopically suspected columnar-lined (CLE). It a premalignant condition and plays pivotal role the development of esophageal adenocarcinoma. has traditionally been believed to affect Asians less frequently. The aim this study was determine prevalence BE possible associated risk factors Korea.A retrospective analysis 70 103 patients who had undergone their first upper endoscopies...
Colorectal cancer incidence is rapidly rising in many Asian countries, with rates approaching those of Western countries. This study aimed to evaluate the prevalence and trends colorectal adenomas by age, sex, risk strata asymptomatic Koreans.Cross-sectional 19,372 consecutive participants aged 20 79 years undergoing screening colonoscopy at Center for Health Promotion Samsung Medical Korea from January 2006 June 2009.Among average risk, without a history polyps or family cancer, advanced...
The incidence of infectious spondylodiscitis (IS) has increased in recent years due to an increase the numbers older patients with chronic diseases, as well immunocompromise, steroid use, drug abuse, invasive spinal procedures, and surgeries. However, research focusing on IS general population is lacking. This study investigated treatment trends South Korea using data obtained from Health Insurance Review Assessment Service. A total 169,244 (mean age: 58.0 years) diagnosed 2010 2019 were...
Background An electronic medical record (EMR) database of a large unselected population who received screening colonoscopies may minimize sampling error and represent real-world estimates risk for target lesions advanced colorectal neoplasia (CRN). Our aim was to develop validate prediction model assessing the probability CRN using clinical data warehouse. Methods A total 49,450 screenees underwent their first colonoscopy as part health check-up from 2002 2012 at Samsung Medical Center,...
Colorectal cancers in the proximal or distal site have distinct clinical characteristics. In this study, authors compared risk factors of and colorectal cancer.A 16-page questionnaire was administered to 529 patients with cancer before operation. Cancers were classified as relative splenic flexure. Of these patients, 6 excluded because presence synchronous cancers. Data 523 analyzed.Total numbers 123 400. The proportion Type 2 diabetes significantly higher for (P = 0.034), whereas a greater...
Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated efficacy safety ESD in patients with comorbid diseases.The outcomes 337 who underwent early gastric cancer at Samsung Medical Center from April 2003 December 2006 were analyzed retrospectively. The Charlson comorbidity scale was used...