A5101995443- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Reproductive Biology and Fertility
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Pluripotent Stem Cells Research
- Eosinophilic Esophagitis
- Infectious Diseases and Tuberculosis
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Ocular Diseases and Behçet’s Syndrome
- Diverticular Disease and Complications
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- Nutrition, Health and Food Behavior
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Metastasis and carcinoma case studies
Murdoch Children's Research Institute
2024
Konkuk University
2007-2009
Konkuk University Medical Center
2008
Suwon Research Institute
2007
LSI Solutions (United States)
2005
Ajou University
2005
Sungkyunkwan University
1999-2004
Samsung Medical Center
1999-2004
Samsung (United Kingdom)
2001
Maria Fertility Hospital
1998
In human in-vitro fertilization (IVF)-embryo transfer, the culture environment differs from in-vivo conditions in that oxygen concentration is higher, and such mouse embryos show a higher of reactive species (ROS) simple media. ROS are believed to cause damage cell membranes DNA fragmentation somatic cells. This study was conducted ascertain level H2O2 within morphological features induced by H2O2. A total 62 oocytes (31 fragmented, 15 non-fragmented embryos, 16 unfertilized oocytes)...
Although the prognosis for pancreatic cancer is generally poor, it well known that survival rate resected much higher than more conservative treatment. The importance of early detection emphasized resection cancer. Measurement serum carbohydrate antigen (CA) 19-9 has shown satisfactory sensitivity and predictive value in symptomatic patients, but no available data been found on healthy asymptomatic subjects. Thus, authors aimed to determine clinical usefulness CA as a screening tool...
We analyzed The incident, clinical features. and the long-term sequelae of arthropathy in 84 patients with Behcet's disease. Alter a mean disease duration 44.7 months, 59 (70%) had al least 1 episode arthropathy. Of these, was present time diagnosis majority (75%). In remainder, developed 4 to 80 months (mean 29) after Female were significantly more likely have than malt (89 versus 56%. p = ().()()6) pattern involvement oligoarticular 75%. monoarticular 23%. polyarticular 2% these patients....
Primary epiploic appendagitis (PEA) is an uncommon cause of abdominal pain that occurs either from appendageal torsion or spontaneous thrombosis draining vein. frequently misdiagnosed as appendicitis diverticulitis, depending on its location.Clinical and radiologic characteristics 8 patients with PEA were retrospectively reviewed compared 18 acute diverticulitis.Patients presented lower recent onset was localized to the left (seven cases) right (one case) quadrants. Well-localized tenderness...
Functional gastrointestinal disorders are more common in women relation to the fluctuations of female sex hormones. We tried know gender-related differences prevalence irritable bowel syndrome and symptoms according menstrual phase. A total 253 before menopause 252 men below age 50 were examined by a gastroenterologist after completing questionnaire. Blood tests, endoscopic procedures, imaging studies done, if needed. Women subclassified into three groups their menstruation period; phase,...
The chromosomes of leucocytes cultured from the peripheral blood 49 primitive Yanomama Indians Venezuela were studied to determine types and frequencies aberrations in a human population not exposed same exogenous agents as civilized man. In all but one instance, 100 cells per individual scored. 13 cases, we found or more with multiple complex breaks rearrangements, represented by tetracentric, tricentric, numerous dicentric chromosomes. From standpoint chromosomal damage, these are among...
Two lymphocytoid cell lines have been established from a patient with the Lesch-Nyhan syndrome. The cells are deficient in hypoxanthine-guanine phosphoribosyltransferase, as demonstrated by their failure to incorporate [H3]hypoxanthine and inability grow medium which they were nutritionally dependent upon exogenous hypoxanthine. This represents first establishment of presumptively permanent human that specific enzyme.
We evaluated the relationship between Helicobacter pylori (H. pylori) infection and gastric sensitivity to distention or emptying rate define role of H. in pathogenesis functional dyspepsia.Gastric barostat, scintigraphy, 13C urea breath test were performed 34 consecutive patients with dyspepsia.Between pylori-positive -negative dyspepsia, there no significant differences basal tone (57.2 +/- 15.0 ml vs 66.8 18.3 ml), compliance (41.0 11.2 ml/mm Hg 38.2 11.8 Hg), threshold first sense (3.6...
The authors conducted a retrospective review of 234 bone scans stomach cancer patients who had been diagnosed at the Seoul National University Hospital. In 106 cases (45.3%), there were abnormal scan results, suggestive metastases. most common site metastases was spine, followed by ribs, pelvis, femur, and skull. These sites similar to those known for other malignant diseases. incidence increased according duration disease, especially within 12 months after diagnosis in with stage III...
Immunoglobulin production was studied in established lines of normal human lymphocytes. Three which produced both immunoglobulin G and M were cloned. Among the 25 immunoglobulin-producing clones, 23 classes immunoglobulins. These findings suggest that phenomenon genic exclusion does not hold for lymphocytoid cells culture.
Background Chronic expression of cylcooygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) may play an important role in gastric carcinogenesis. Thus, the purpose our study was to assess COX-2 iNOS messenger RNA (mRNA) cancer investigate correlation between mRNA these patients. Study Twenty-three carcinoma specimens accompanying adjacent were obtained from surgical resection. The examined by comparative reverse transcription polymerase chain reaction. Results Cylcooygenase-2...
Sildenafil relaxes smooth muscle by blocking type 5 phosphodiesterase, which destroys nitric oxide-stimulated cyclic guanosine monophosphate. The aim of this study is to investigate the change lower esophageal sphincter (LES) and body motility with lapse time after sildenafil infusion in normal male adults.After basal manometry eight healthy adult volunteers, we infused a 50-mg tablet dissolved water stomach through catheter observed changes LES time. We randomized population into two...
The clinicopathological and biological significance of the expression iNOS in pancreatic cancer remains unclear. goal this study was to determine possible roles clinical cancer.Seventy-two adenocarcinoma tissue specimens were obtained by surgical resection. We investigated immunohistochemical 72 patients with respect variable characteristics, proliferation activity (assessed Ki-67 expression), apoptosis TUNEL stain), microvessel density CD34 expression; angiogenesis).Immunohistochemical...
Background: Proton pump inhibitor‐based triple therapies are recommended as the first‐line treatment for Helicobacter pylori eradication. Aim: To evaluate efficacies of low‐dose clarithromycin therapy and tinidazole‐containing in a metronidazole resistance prevalent area to compare with standard therapy. Methods: In randomized, multicentre, prospective study, total 352 patients duodenal ulcer or non‐ulcer dyspepsia were randomly divided into three groups according administered regimen:...
To evaluate the clinical significance of enlarged perihepatic lymph nodes in patients with chronic hepatitis B.Enlargement node is a common finding during ultrasonography hepatitis. Its relation liver histology and viremia was reported C, but little has been known about its B.We evaluated lymphadenopathy B. In 50 biopsy-proven B 15 healthy controls, volume by possible correlation biochemical tests, activity index, investigated.Perihepatic detected 48 (volume = 3.4 +/- 2.4 mL) two controls...
One of the major limitations curative resection in patients with pancreatic cancer is local tumor extension to mesenteric vessels. Thus, purposes our study were assess clinical value contrast-enhanced spiral computed tomography (CT) predicting resectability and survival suspicious vascular invasion influence on these patients. We enrolled 40 who suspected having an involvement adjacent large vessels subsequently underwent operation intent study. Resectability correlated CT findings such as...
Nitric oxide (NO) is synthesized enzymatically from L-arginine by NO synthase, which measured inducible synthase (iNOS). Helicobacter pylori (H. pylori) infection produces a state of chronic immunostimulation in the gastric epithelium. Infection with cagA+ H. has greater degree inflammation and epithelial cell damage. Therefore, we compared levels iNOS patients relation to cagA status pylori-related disease.One hundred seven patients, including 51 cancer, 12 ulcer, 18 duodenal ulcer 26...
The intestinal lesion of Behçet's colitis shows aphthoid or punched-out ulceration. However, the diagnosis should be based on presence other stigmata syndrome, since these morphological characteristics are not pathognomonic by themselves. Furthermore, syndrome could appear simultaneously separately with intervals several months to years. Besides, when a physician first meets patients ulcerations shape, if they do have any stigma has some difficulty in making colitis. purpose this...
Alterations in the normal control of apoptosis and cell proliferation are important factors multistep colorectal carcinogenesis. The aim this study was to determine frequency rectal cancers examine their relationship clinicopathological variables expression bcl-2 p53.Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining immunohistochemical for Ki-67, bcl-2, p53 were performed on paraffin-embedded tissue samples 57 cancers.There a positive linear...