Jee Young Kwon
A5029559145- Cancer Research and Treatments
- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Cancer-related Molecular Pathways
- Chromosomal and Genetic Variations
- Air Quality Monitoring and Forecasting
- Radiation Therapy and Dosimetry
- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Carcinogens and Genotoxicity Assessment
- Noise Effects and Management
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Radiation Dose and Imaging
- Hearing, Cochlea, Tinnitus, Genetics
- Genomic variations and chromosomal abnormalities
- Nuclear Physics and Applications
- Ovarian cancer diagnosis and treatment
- Chronic Lymphocytic Leukemia Research
- Genetically Modified Organisms Research
- Microplastics and Plastic Pollution
- Genomics and Rare Diseases
Jackson Laboratory
2015-2025
Ewha Womans University
2016-2022
Vancouver General Hospital
2021
Dongguk University
2010-2016
Kyung Hee University
2008-2014
The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies human genetic diversity and disease association. Here, we apply a suite long-read, short-read, strand-specific technologies, optical mapping, variant discovery algorithms to comprehensively analyze three trios define the full spectrum variation in haplotype-resolved manner. We identify 818,054 indel (<50 bp) 27,622 SVs (≥50 per genome. also discover 156 inversions genome 58 intersect...
Short tandem repeats (STRs) and variable number (VNTRs) are important sources of natural disease-causing variation, yet they have been problematic to resolve in reference genomes genotype with short-read technology. We created a framework model the evolution instability STRs VNTRs apes. phased assembled 3 ape (chimpanzee, gorilla, orangutan) using long-read 10x Genomics linked-read sequence data for 21,442 human discovered 6 haplotype-resolved assemblies Yoruban, Chinese, Puerto Rican...
Abstract Background Comparisons of the gut microbiome lean and obese humans have revealed that obesity is associated with plus changes in numerous environmental factors, including high-fat diet (HFD). Here, we report two species Bifidobacterium are crucial to controlling metabolic parameters Korean population. Results Based on microbial analysis from 99 individuals, observed abundance longum bifidum was markedly reduced individuals increased visceral adipose tissue (VAT), body mass index...
ABSTRACT The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies human genetic diversity and disease association. Here, we apply a suite long-read, short-read, strand-specific technologies, optical mapping, variant discovery algorithms to comprehensively analyze three parent–child trios define the full spectrum variation in haplotype-resolved manner. We identify 818,054 indel (<50 bp) 27,622 SVs (≥50 per genome. also discover 156...
Significance Gastric cancer (GC) is one of the major causes cancer-related deaths worldwide, but targeted therapy for GC limited. Here, we identified two druggable targets from genomic alteration profiling 103 patients with Asia and validated target suitability using patient-derived xenograft models, which recapitulate tumor biology observed in patients. Combination irinotecan (standard treatment) a BCL2L1 ( BCL2 -like 1)-targeted drug was effective size reduction tumors having amplification...
Abstract An unbalanced microbial ecosystem on the human skin is closely related to diseases and has been associated with inflammation immune responses. However, little known about role of microbiome aging. Here, we report that Streptococcus species improved structure barrier function, thereby contributing anti-aging. Metagenomic analyses showed abundance in younger individuals or those having more elastic skin. Particularly, isolated pneumoniae , infantis thermophilus from face young...
Abstract Introduction: SM09419 is an experimental small-molecule pan-inhibitor targeting CLK and DYRK kinases, which play a key role in RNA splicing other oncogenic processes. exhibited promising activity preclinical models of TP53- FLT3-mutated acute myeloid leukemia, its analog cirtuvivint (SM08502) broad evidence therapeutic benefit solid tumors. Cirtuvivint clinical trials adults with AML (NCT06484062) sarcomas (SELNET-7-2/EuCT#: 2024-511987-10-00). To evaluate the kinase inhibition...
Abstract Introduction: Vobra duo, a duocarmycin-based humanized ADC (drug-to-antibody ratio is ∼2.7) targeting B7-H3, shows robust in vivo activity against range of adult cancer models, and favorable pharmacokinetic safety profile cynomolgus monkeys. Initial results from the single agent phase 1 clinical trial vobra duo (NCT03729596) showed manageable side effects promising objective response rates metastatic castration-resistant prostate cancer. B7-H3 highly expressed pediatric solid...
Abstract Introduction: OBI-3424 is a DNA alkylating prodrug activated by aldo-keto reductase family 1 member C3 (AKR1C3). Elevated AKR1C3 expression observed in variety of tumors including prostate cancer, T-cell acute lymphoblastic leukemia (T-ALL), hepatocellular carcinoma (HCC) and hepatoblastoma. Interim Phase 2 data advanced HCC patients showed encouraging survival benefit good safety profile. Evaluation across spectrum pediatric highest T-ALL Prior preclinical testing patient-derived...
Gastric cancer (GC) is one of the leading causes cancer-related deaths worldwide. Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 13-23% all GC cases and patients with HER2 overexpression exhibit a poor prognosis. Lapatinib, dual EGFR/HER2 tyrosine kinase inhibitor, an effective agent to treat HER2-amplified breast but it failed gastric clinical trials. However, molecular mechanism lapatinib resistance not well studied.We employed unbiased, genome-scale...
Background: Silica dioxide (SiO 2 ) has been used in various industrial products, including paints and coatings, plastics, synthetic rubbers, adhesives. Several studies have investigated the genotoxic effects of SiO ; however, results remain controversial due to variations evaluation methods applied determining its physicochemical properties. Thus, well characterized chemicals standardized are needed for better assessment genotoxicity nanoparticles. Methods: The was evaluated using two types...
Erlotinib is highly effective in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. However, despite initial favorable responses, most rapidly develop resistance to erlotinib soon after the treatment. This study aims identify new genes and pathways associated mechanisms order novel therapeutic strategies. Here, we induced knockout (KO) mutations erlotinib-resistant human cells (NCI-H820) using a genome-scale CRISPR-Cas9 sgRNA library screen for involved...
Abstract Pancreatic cancer exhibits a characteristic tumor microenvironment (TME) due to enhanced fibrosis and hypoxia is particularly resistant conventional chemotherapy. However, the molecular mechanisms underlying TME-associated treatment resistance in pancreatic are not fully understood. Here, we developed an vitro TME mimic system comprising cells, fibroblasts immune stress condition, including gemcitabine. Cells with high viability under showed evidence of increased direct cell-to-cell...
Abstract The prevalence of highly repetitive sequences within the human Y chromosome has led to its incomplete assembly and systematic omission from genomic analyses. Here, we present long-read de novo assemblies 43 diverse chromosomes spanning 180,000 years evolution, including two deep-rooted African lineages, report remarkable complexity diversity in size structure, contrast with low level base substitution variation. varies extensively 45.2 84.9 Mbp include, on average, 81 kbp novel...
Air pollutants are associated with inflammatory diseases such as otitis media (OM). Significantly higher incidence rates of OM reported in regions air pollution. Diesel exhaust particles (DEPs) comprise a major class contaminants among numerous pollutants, and they characterized by carbonic mixture polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs, small amounts sulfate, nitrate, metals other trace elements. DEP exposure is risk factor for diseases. Our previous study identified potential...