A5100410632- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Genetic and rare skin diseases.
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Tuberculosis Research and Epidemiology
- Veterinary medicine and infectious diseases
- Immune Cell Function and Interaction
- Diverticular Disease and Complications
- Connective tissue disorders research
- Neonatal skin health care
- Metabolism and Genetic Disorders
- Autoimmune and Inflammatory Disorders Research
- Neurological and metabolic disorders
- IL-33, ST2, and ILC Pathways
- Dermatological and Skeletal Disorders
- Anorectal Disease Treatments and Outcomes
- Diet and metabolism studies
- Bone fractures and treatments
Seoul St. Mary's Hospital
2025
Catholic University of Korea
2008-2025
Songdo Hospital
2011-2022
Yonsei University
2016
Although the incidence of inflammatory bowel disease [IBD] is increasing in Asia, data on long-term epidemiological trends are limited. We performed a 30-year longitudinal study to investigate temporal epidemiology Crohn's [CD] and ulcerative colitis [UC] Seoul, Korea.This population-based included 1431 IBD patients [418 CD, 1013 UC] diagnosed between 1986 2015 Songpa-Kangdong district Korea. Temporal incidence, prevalence, phenotype at diagnosis were analysed.The adjusted mean annual rates...
<h3>Objective</h3> Crohn9s disease (CD) is an intractable inflammatory bowel (IBD) of unknown cause. Recent meta-analysis the genome-wide association studies (GWAS) and Immunochip data identified 163 susceptibility loci to IBD in Caucasians, however there are limited other populations. <h3>Methods</h3> We performed a GWAS two validation Korean population comprising total 2311 patients with CD 2442 controls. <h3>Results</h3> confirmed four previously reported loci: <i>TNFSF15</i>,...
The biosimilar of infliximab, CT-P13, has recently been shown to be equivalent infliximab in both efficacy and safety the treatment rheumatologic diseases. However, no data are available with respect drug's patients inflammatory bowel disease (IBD). We aimed assess CT-P13 IBD patientsThis was a retrospective multicenter study including anti-tumor necrosis factor (TNF) naïve who switched from biologic originator CT-P13.In anti-TNF Crohn's (CD) (n = 32), clinical response remission rates were...
Objective: To evaluate the safety and efficacy of CT-P13 (Remsima®) in patients with inflammatory bowel disease (IBD) South Korea. Methods: This post-marketing study included active moderate-to-severe Crohn's (CD), fistulizing CD (FCD), or ulcerative colitis (UC) treated followed for 30 weeks. Assessments treatment-emergent adverse events (TEAEs) disease-specific clinical response remission. Results: No unexpected TEAEs were observed 173 recruited to date. occurred 18.1, 16.7, 26.9% CD, FCD,...
Crohn's disease (CD) is an intractable inflammatory bowel of unknown cause. Recent genome-wide association studies CD in Korean and Japanese populations suggested marginal sharing susceptibility loci between Caucasian Asian populations. As the 7 identified altogether explain 5.31% risk for CD, objective this study was to identify additional population.Using ImmunoChip custom single-nucleotide polymorphism array designed dense genotyping 186 through GWAS, we analyzed 722 individuals with 461...
No population-based study has evaluated the natural course of UC over three decades in non-Caucasians. We aimed to assess long-term Korean patients with a cohort.This population-based, Songpa-Kangdong IBD cohort included all (n=1013) newly diagnosed during 1986-2015. Disease outcomes and their predictors were evaluated.During median follow-up 105 months, overall use systemic corticosteroids, thiopurines antitumour necrosis factor (anti-TNF) agents was 40.8%, 13.9% 6.5%, respectively. Over...
Failure rates of Helicobacter pylori eradication treatment turned out to be exceeding 10%, causing recurrence peptic ulcers. In the case failure, Korean College Research and Practice recommends quadruple therapy consisting proton pump inhibitor, bismuth, tetracycline metronidazole. Many reports regarding have been reported. However, most were limited by short follow-up periods. Hence, we evaluated efficacy metronidazole containing as a second line from April, 1996 through July,...
Background/Aims In spite of the improvement medical treatment for peptic ulcer disease (PUD), PUD is still one common upper gastrointestinal diseases. The purpose this study was to evaluate risk factors and general characteristics Korean patients diagnosed as at a single third referral center. Methods A total 310 patients, through endoscopy during year 2007 Seoul National University Bundang Hospital were, retrospectively, evaluated regarding age, gender, Helicobacter pylori (H. pylori)...
Background: A dysregulated mucosal immune response to the intestinal environment in a genetically susceptible host is hypothesized be critical pathogenesis of Crohn's disease (CD).Therefore, we examined CD-susceptibility genes involved through genome-wide association study and consecutive genotyping human leukocyte antigens (HLAs) killer cell immunoglobulin-like receptors.Methods: An initial was performed with 275 CD patients 2369 controls from Korean population.To validate loci identified...
Abstract Background and Aim A biosimilar of infliximab, CT‐P13 (Remsima®) has the potential to reduce treatment costs enhance access biological therapy for inflammatory bowel disease (IBD) patients. However, long‐term clinical data on its use IBD are currently sparse. We aimed investigate efficacy safety in a large, real‐life cohort. Methods total 368 patients (227 with Crohn's [CD] 141 ulcerative colitis [UC]) treated at 16 referral hospitals Korea between July 2012 December 2017 were...
Background/Aims This study was performed to evaluate whether the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates and eradication rate H. could be different between cancer non-cancer patients. Methods were isolated from gastric mucosal biopsy specimens obtained 269 Koreans, who did not have any therapy history diagnosed as one following diseases; chronic gastritis, benign ulcer, duodenal ulcer or cancer. The susceptibilities amoxicillin,...
Free perforation is the most severe and debilitating complication associated with Crohn's disease (CD), it usually requires emergency surgery. The aim of this study was to evaluate incidence free among Korean patients CD. CrOhn's cliNical NEtwork CohorT (CONNECT) conducted nationwide in Korea, who were diagnosed CD between 1982 2008 included retrospective study. We investigated these their clinical characteristics. A total 1346 analyzed 88 (6.5%) identified mean age group 31.8 ± 13.0 years,...
The long-term course of Crohn's disease (CD) has never been evaluated in non-Caucasian population-based cohorts. aim the present study was to evaluate longterm prognosis Korean CD patients well-defined Songpa-Kangdong inflammatory bowel cohort.Outcomes and their predictors were for 418 diagnosed with between 1986 2015.During a median 123 months, systemic corticosteroids, thiopurines, anti-tumor necrosis factor (TNF) agents administered 58.6%, 81.3%, 37.1% patients, respectively. Over time,...
The prospective Crohn's Disease Clinical Network and Cohort Study is a nationwide multicenter cohort study of patients with disease (CD) in Korea, aiming to prospectively investigate the clinical features long-term prognosis associated CD.Patients diagnosed CD between January 2009 September 2019 were enrolled. They divided into two cohorts according year diagnosis: 1 (diagnosed 2011) versus 2 (between 2012 2019).A total 1,175 included, median follow-up duration was 68 months (interquartile...
We aimed to evaluate the clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using wellestablished population-based cohort Songpa-Kangdong district Seoul, Korea.Clinical were compared between two groups: EOUC, defined as UC diagnosed individuals aged ≥60 years non-EOUC (N-EOUC), 18 59 years.We identified 99 with EOUC (10.3%) 866 N-EOUC (89.7%) 1986 2015. During median follow-up 104.5 months, overall exposure...
The long-term outcomes of paediatric-onset inflammatory bowel disease [pIBD] in non-Caucasian populations are unknown. We therefore evaluated and compared the clinical features pIBD with those adult-onset IBD [aIBD] using a population-based cohort Songpa-Kangdong district Seoul, Korea. Clinical characteristics prognoses were between two groups: [defined as <18 years age at diagnosis] aIBD [18-59 diagnosis]. identified 131 patients (48 ulcerative colitis [UC], 83 Crohn's [CD]) 1192 [866 UC,...
We aimed to compare trough infliximab levels and the development of antidrug antibody (ADA) for 1 year between Crohn's disease (CD) ulcerative colitis (UC) patients who were biologic-naive, evaluate their impact on clinical outcomes.This was a prospective, multicenter, observational study. Biologic-naive with moderate severe CD or UC started CT-P13, an biosimilar, therapy enrolled. Trough drug ADA measured periodically after CT-P13 initiation.A total 267 received treatment included (CD 168,...