First-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for patients with advanced non-small cell lung cancer who were selected on the basis of EGFR mutations have improved progression-free survival acceptable toxicity compared to standard chemotherapy. However, acquired resistance EGFR-TKIs has been identified as an important clinical problem. Transformation small (SCLC) is a rare mechanism EGFR-TKI therapy. We describe case 61-year-old man presented...

본 연구는 대학 신입생들의 우울, 불안 및 신체증상에 대한 확인과 이에 영향을 미치는 대학생활 특성을 규명하기 위한 목적으로 시행된 서술적 조사연구이다. H대학에 진학 중인 300명의 신입생들을 대상으로 2013년 4월 22일부터 26일까지 구조화된 질문지를 이용하여 진행되었으며, 수집된 자료는 t-test, one-way ANOVA, Pearson's correlation coefficient, multiple regression을 통해 분석되었다. 연구 결과는 다음과 같다. 첫째, 점수가능범위 1~5점 중 우울 2.33점, 1.94점, 신체건강 1.63점으로 나타났으며, 여학생일수록, 지각된 자아존중감이 낮을수록 불안, 그리고 신체증상 점수가 높았다. 둘째, 특성은 우울을 46.1%, 불안을 26.3% 설명하고 있었으며, 특성과 불안은 신체건강을 35.8% 있었다. 결과가 정신 신체건강의 중요성에 이해를 높일뿐만 아니라, 신체증상으로 인한 건강문제 발생을 예측하고...

Residual pleural thickening (RPT) is the most frequent complication associated with tuberculosis, and may occur even after successful anti-tuberculosis medications. Matrix metalloproteinases (MMPs) are zinc-dependent proteinases capable of degrading all components extracellular matrix. The proteolytic action MMPs be involved in pathogenesis tuberculosis. MMP-9, secreted by monocytes lymphocyte, lead to long-term fibrosis. aim present study was determine whether MMP-2 and/or MMP-9 their...

We aimed to investigate the effectiveness of Korean national five-day residential smoking cessation program and factors affecting long-term participants. The (2017-2018) recruited smokers with a duration ≥ 20 years who have attempted quit more than twice and/or chronic morbidities. Participants underwent an intensive intervention, including individual psychological therapy, group medical counseling, pharmacotherapy. 6-month continuous abstinence rate (CAR) was assessed via self-reports,...

Purpose This study was conducted in order to explore the factors affecting hope nursing students. Methods A total of 166 students participated study. Data analyzed using SPSS WIN 18.0. Results The mean scores for social support, self-efficacy, and were above-average level. There significant differences according religion, academic achievement, satisfaction with majors. Hope correlated positively support self-efficacy. predictors included major. regression model explained 12.7% hope....

Background Malnutrition is a well-known risk factor of falls, although studies examining the association between nutritional status and falls are rare. We aimed to investigate according gender among Korean older adults. Methods The study included 10,675 participants (4,605 men 6,070 women) aged 65 years used data from 2011 Survey Living Conditions Welfare Needs Older Persons. Nutritional was assessed using Screening Initiative checklist, were categorized into following groups: "good,"...

Background: Prediabetes is a metabolic state between normoglycemia and diabetes known to carry higher risk of developing overt cardiovascular disease (CVD). The relative absolute risks all-cause mortality, CVD, coronary heart disease, stroke in prediabetes patients, as well diabetic than that patients with normoglycemia. Carotid intima-media thickness (cIMT) method used stratify CVD risk. In this study, we aimed determine whether the neutrophil-to-lymphocyte ratio (NLR) correlates cIMT...

This study aimed to investigate the effect of intervention positive mental imagery on anhedonia and underlying reward mechanism in depression, explore sustainability impact following stress induction. Participants reporting anhedonic depressive symptoms (N=54) were randomly assigned either a condition or verbalization condition, former utilizing stimuli only, latter language-based meaning. both conditions completed computerized picture-word task for generation arithmetic The results showed...

The anti-inflammatory efficacy of radiation therapy (RT) with single fractions below 1.0 Gy has been demonstrated in Alzheimer's disease mouse models. As neuroinflammation is also a major pathological feature Parkinson's (PD), RT may be effective PD treatment. Therefore, this study aimed to investigate the effect low-moderate dose (LMDRT, 0.6 Gy/single dose, for 5 days) exposure 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, intraperitoneally, consecutive days)-induced model....

Purpose: This study examined the effects of Testicular Self-Examination (TSE) small-group education on knowledge, self-efficacy, and performance intention in male college students. Method: A non-equivalent pre-post test quasi-experimental design was used. Out 74 students selected by convenient sampling, 37 were assigned to experimental group given TSE education. 60-minute program consisted lecture, demonstration, practice, discussion, Q&A. Result: With an initial homogeneity between two...

In this study, beauty food activities were determined for extracts of Saurus chinensis as functional food. Tyrosinase inhibitory effect was increased more 4 folds by ultra-fine grind technology than normal in ethanol from chinensis. A ground used to increase the extraction yield bioactive compounds medicinal plants. activity, which is related skin-whitening, confirmed be 100% at 1,000 ppm phenolics. Anti-wrinkle activity showing 30% inhibition above phenolic concentration. The elastase water...

Purpose: This study is intended to compare musculoskeletal characteristics and Bone Mineral Density (BMD)-related factors between male female students in a university. Methods: descriptive used self-report questionnaires physical measurements collect data. Subjects were 64 67 university students. The asked BMD-related such as diet, exercise, mental health, lifestyle. Data analyzed using statistics, t-test, <TEX>$x^2$</TEX>-test, Fisher's exact test correlation analysis. Results: group showed...