Fluorescence in situ hybridization (FISH) using tumor tissue is the gold standard for detection of anaplastic lymphoma kinase (ALK) rearrangement non-small cell lung cancer (NSCLC). However, this method often not repeatable due to difficulties acquisition tissues. Blood-based liquid biopsy reverse transcription polymerase chain reaction (RT-PCR) expected be useful overcome limitation. Here, we investigated feasibility plasma and platelets ALK prediction inhibitor treatment outcomes.ALK-FISH...

Menopause is characterized by changes in reproductive hormone levels that can negatively affect bone. Chronic kidney disease (CKD) and tooth loss are also important common health issues after menopause. This study aimed to evaluate the association between CKD postmenopausal women.

Recently, the extensive spread of some algae along coastlines has surged into unmanageable thick decomposition layers. This study aimed to demonstrate use Sargassum horneri as a biomass resource for ethanol production through continuous hydrolysis, enzymatic saccharification, and fermentation process. Sugars from S. were obtained using combination thermal acid hydrolysis saccharification. The optimal conditions involved 10% (w/v) slurry treated with 100 mM H2SO4 at 121 °C 60 min;...

The goal of this study was to investigate the chemical and microbiological characteristics kimchi products distributed in Japan (5 brands, J-products) Korea (2 K-products). When their average analyses were compared, J-products showed higher values pH, total sugar acetic acid contents, while K-products number lactic bacteria, alcohol contents including textural hardness or chewiness. In addition, analysis great variation composition levels regarding J-products, fact revealed that different...

This study evaluated the effectiveness and safety of an experimental bleaching strip (Medison dental whitening strip, Samsung medical Co., Anyang, Korea) containing 2.9% hydrogen peroxide. Twenty-three volunteers used strips for one a half hour daily 2 weeks. As control group, same in which peroxide was not included were by 24 with protocol. The shade change (ΔE*, color difference) twelve anterior teeth measured using Shade Vision (X-Rite Inc., S.W. Grandville, MI, USA), Chroma Meter...

본 연구는 탱자(Poncirus trifoliata) 과피의 80% 에탄올 추출물(PTP)에 대한 항산화 활성과 면역 활성을 유자(Citrus junos) 과피 추출물(CJP)과 비교하였다. 총 phenol 함량과 flavonoids 함량은 PTP가 각각 <TEX>$60.75{\pm}1.15$</TEX> mg/100 g과 <TEX>$33.75{\pm}0.15$</TEX> g이었으며, 이는 CJP에 비해 다소 낮았다. PTP의 활성은 농도 의존적으로 증가하였으며 CJP의 비슷하게 나타났다. 면역반응 중 대식 세포가 생성하는 NO 생성량을 측정한 결과 CJP와 PTP를 단독으로 처리한 경우와 LPS와 혼합하여 경우 모두 1 mg/ml까지는 대조구와 비교하여 증가하였으나 고농도에서는 감소하는 경향을 나타내었다. 비장세포를 이용한 면역세포 증식능에서 첨가한 경우, 감소하였다. In this study, we compared with ethanol extracts from peel...

본 연구는 MCF-7 유방암 세포에 대한 유자(CJP)와 탱자 (PTP) 과피 추출물의 항암 활성과 환경호르몬에 의해 유도된 암세포의 증식 억제 효과에 대하여 조사하였다. CJP와 PTP를 300 mg/ml 농도에서 72시간 처리하였을 경우, 성장을 저해하였고 세포사멸을 유도하였다. 세포의 형태학적 변화는 500 7시간 경우 관측되었고 세포사멸은 capase-3의 활성화에 의하여 유도되었다. 증식은 PTP의 처리로 인하여 농도 의존적으로 감소하였으며, 농도에서는 대조군과 비교하였을 때 각각 70%와 80% 이상 감소하였다. In this study, anti-cancer activities of peel Citrus junos (CJP) and Poncirus trifoliata on breast cancer cells, anti-proliferative effects cells induced by environmental hormones were investigated....

Background: As the world population continues to age, interest in muscle strength loss older people is increasing. This study aimed confirm association between present teeth and Korea. Methods: Using data extracted from 2014–2019 Korea National Health Nutrition Examination Survey, we analyzed 5136 aged 65–79 years. The were based on 20 teeth, which criteria for comfortable mastication. of risk low according was assessed using multiple logistic regression analysis, confirmed by dividing into...

그간의 억양 전사 체계에 대한 비판적 논의와 새로운 체계의 개발에도 불구하고 국어 억양의 전사는 대체로 K-ToBI(Jun 2000)를 활용하는 데에 머물러 있었다. 이는 억양을 전사할 수 있는 종합적인 검토가 부재했기 때문으로 보인다. 본 연구는 이러한 간극을 메우기 위해 음성전사 개념과 실제에 고찰을 바탕으로 표면 층위를 체계를 종합적으로 검토해 보는 목적이 있다. 음성전사는 층위을 기록하는 것으로서 생성음운론에서 형태소 단위의 기저형을 설정하고 음운규칙을 설명하는 기초 작업이 되어 왔다. 이때, 체계음성을 이용한 간략전사와 구체음성까지 세밀전사로 양분되었다. 본고는 자립분절-율격 이론을 기반으로 체계가 억양에도 적용되며, 체계도 나눌 있음을 논하였다. 구체적으로, 간략전사의 체계로는 K-ToBI와 IPrA(Jun et al. 2018)를, 세밀전사의 PoLaR(Ahn 2019)과 INTSINT(Hirst 1987)를 검토하였다. 또한 기존의 시각과 달리, 이들 체계는...

Objectives: The present study was carried out to identify the effects of commercially available fermented milk on surfaces composite resins.Methods: experiment included 6 groups: Fermented (Group 3), supplemented with 3% calcium 4), specimens coated fluoride and then treated 5), 6), mineral water 1), carbonated beverage 2).The prepared were immersed in experimental solution analyze test fluid resin specimens.The degree microhardness each specimen surface subsequently measured.The results...

Objectives:The aim of this study is to investigate the mechanical properties and antibacterial effects on Streptococcus mutans composite resins containing phytoncide.Methods: Phytoncide was mixed with commercial at 0 (control), 1.25, 2.5, 3.75, 5.0 weight percentage (wt%).Mechanical related such as surface hardness, depth cure, flexural strength were measured.Antibacterial analyzed by using (ATCC 25175).The results one-way analysis variance followed Tukey's test (p<0.05).Results: Composite...

Objectives:The purpose of this study was to investigate the possibility preventing dental erosion caused by fermented milk in early carious teeth applying 0.2% sodium fluoride tooth surface and adding 0.5% calcium drink.Methods: We selected experimental drink Yakult, which is best-selling domestic drink.A total five groups were as (mineral water, milk, NaF+fermented NaF+(fermented milk+0.5% Ca), NaF+Distilled water groups).After forming artificial caries, pH cycling administered for days...

Objectives : This study was performed in order to investigate an immediate improvement effect of nasal obstruction after having patient with chronic rhinitis use spray cavity distilling Korean medicine, satisfaction for its fragrance and irritation continuance time. Methods A questionnaire therapeutic 1, 2 3 weeks later using by targeting 13 patients who used medicine distillate over among the visited Sangji University Medicine Hospital whose symptoms were determined as whom prescribed....

Objective This study aimed to investigate the effects of fluoride-containing acidic tea beverages on bovine teeth surfaces. Methods The pH values and fluoride concentrations 11 kinds mineral water 23 were measured. Seopyenje black with 3.48 chosen for experimental group. Distilled that did not contain had same value as teas served positive control. Jeju Samdasoo waters neural (pH 7.52) no negative Bovine in each group submerged 10 minutes. Thereafter, surface microhardness was measured...

Objectives We examined the effect of commercial plum beverages on dental erosion and whether addition calcium to these would inhibit erosion. Methods analyzed three groups as follows: Maesil 1 group (Chorok Maesil), 2 (Sunkist plum), both which were selected from commercially-available beverages, Calcium-added maesil (addition 3% Chorok Maesil). For negative positive control groups, Jeju Samdasoo Coca Cola selected, respectively. The characteristics experimental analyzed, specimens immersed...

Cheonggukjang mucoid is typically composed of levan and polygamma glutamate (γ-PGA).In this study, we investigated the effect γ-PGA isolated from on differentiation 3T3-L1 preadipocytes.At 200 µg/mL PL 64 [γ-PGA : (6:4)] significantly inhibited triglyceride accumulation in adipocytes by 23.7% compared to untreated (P<0.05).PL64 treatment reduced expressions fat accumulation-related genes, including peroxisome proliferator-activated receptor γ (pparγ), CCAAT-enhancer-binding protein α...