A5032420755- Zebrafish Biomedical Research Applications
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Developmental Biology and Gene Regulation
- MicroRNA in disease regulation
- Rock Mechanics and Modeling
- Drilling and Well Engineering
- Skin Protection and Aging
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Respiratory viral infections research
- Cardiomyopathy and Myosin Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Kawasaki Disease and Coronary Complications
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- Kruppel-like factors research
- Chronic Lymphocytic Leukemia Research
- Electrostatic Discharge in Electronics
- Acne and Rosacea Treatments and Effects
- Aquaculture disease management and microbiota
Kyung Hee University Hospital at Gangdong
2022-2025
Gangdong University
2022-2024
Kyung Hee University
2023
Seoul National University
2021-2023
Institute for Basic Science
2017-2022
Ulsan National Institute of Science and Technology
2016-2021
Singapore Immunology Network
2020
Agency for Science, Technology and Research
2020
SK Group (South Korea)
2015-2019
University of California, San Diego
2014
During appendage regeneration in urodeles and teleosts, tissue replacement is precisely regulated such that only the appropriate structures are recovered, a phenomenon referred to as positional memory. It believed there exists, or quickly established after amputation, dynamic gradient of information along proximodistal (PD) axis assigns region-specific instructions injured tissue. These specify amount regenerate, well rate at which regenerative growth occur. A striking theme among many...
Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health homeostasis of individuals. Dysregulation HSPC function can lead to blood-related diseases, including cancer. Despite its importance, our understanding genes pathways underlying development associated pathological mechanisms remains limited. To elucidate these unknown mechanisms, we analyzed databases patients with disorders performed functional gene studies using zebrafish....
The actin cytoskeleton controls the overall structure of cells and is highly polarized in chemotaxing cells, with F-actin assembled predominantly anterior leading edge to a lesser degree cell's posterior. Wiskott-Aldrich syndrome protein (WASP) has emerged as central player controlling polymerization. We have investigated WASP function its regulation Dictyostelium demonstrated specific essential role organizing assembly cells. Cells expressing very low levels show reduced significant defects...
Hepatic competence, or the ability to respond hepatic-inducing signals, is regulated by a number of transcription factors broadly expressed in endoderm. However, extrinsic signals might also regulate hepatic as suggested tissue explant studies. Here, we present genetic evidence that Fgf signaling regulates competence zebrafish. We first show endoderm posterior liver-forming region retains competence: using transgenic lines overexpress inducing following heat-shock, found at late...
Encoding the slow skeletal muscle isoform of myosin binding protein-C, MYBPC1 is associated with autosomal dominant and recessive forms arthrogryposis. The authors describe a novel association for in four patients from three independent families weakness, myogenic tremors, hypotonia gradual clinical improvement. carried one two de novo heterozygous variants MYBPC1, p.Leu263Arg variant seen individuals p.Leu259Pro individual. Both are absent controls, well conserved across vertebrate species,...
Guarea genus comprises tropical and subtropical terrestrial herbs inhabiting Central South America. These plants, including guidonia (L.) Sleumer, have anti-inflammatory, analgesic, antibacterial, antiviral, immune-enhancing properties.
Abstract Inflammation is implicated as a cause in many diseases. Most of the anti-inflammatory agents use are synthetic and there an unmet need for natural substance-derived with minimal side effects. Aiouea padiformis belongs to Lauraceae family primarily found tropical regions. While some members genus known possess properties, properties extract (AP) have not been investigated. In this study, we aimed examine function AP through NOD-, LRR- pyrin domain-containing protein 3 (NLRP3)...
A pterygium is a common conjunctival degeneration and inflammatory condition. It grows onto the corneal surface or limbus, causing blurred vision cosmetic issues. Ultraviolet well-known risk factor for development of pterygium, although its pathogenesis remains unclear, with only limited understanding hereditary basis. In this study, we collected RNA-seq from both pterygial tissues (as controls) six patients (a total twelve biological samples) retrieved publicly available data, including...
Accurate prediction of malignancies is important in choosing therapeutic strategies. Although there are many genetic and cytogenetic prognostic factors for acute myeloid leukemia (AML), prognosis difficult to predict because the heterogeneity AML. Prognostic factors, including messenger RNA (mRNA) expression, have been determined other malignancies, but not A total 402 patients from The Cancer Genome Atlas, GSE12417 (GPL96, 97), (GPL570) were included this study. In Kaplan-Meier curve...
Abdominal aortic aneurysm (AAA), when ruptured, results in high mortality. The identification of molecular pathways involved AAA progression is required to improve prognosis. aim the present study was assess key genes for and their functional role. Genomic clinical data three independent cohorts were downloaded from National Center Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) (GSE57691, GSE7084, GSE98278). To develop diagnosis progression-related differentially expressed...
Abstract Zebrafish have emerged as a powerful animal model for investigating the genetic basis of hematopoiesis. Owing to its close and developmental similarities humans, combined with rapid reproduction extensive genomic resources, zebrafish become versatile efficient platform studies. In particular, forward screening approach has enabled unbiased identification novel genes pathways related blood development, from hematopoietic stem cell formation terminal differentiation. Recent advances...
Particulate matter (PM) can cause human diseases, particularly respiratory diseases. Since eyes are directly exposed to the air, they might be adversely affected by PM. Therefore, we determined toxicity caused eye development PM using zebrafish (Danio rerio) embryos. The PM-induced embryo was dependent on dose and time significant morphological defects, reducing total body length area. Reactive oxygen species (ROS) overproduction confirmed in treatment group, antioxidant genes (cat sod2),...
Ionizing radiation (IR) has garnered growing attention because of its biological effects on aquatic organisms and humans. Here, we identify the most impacted organs uncover molecular mechanisms causing changes in context vertebrate development using single‐cell RNA sequencing. Alterations cellular composition functions were explored transcriptomic profiling zebrafish embryos exposed to 5 Gy. Single‐cell sequencing analyses unveiled notable shifts proportions brain/central nervous system...