A5024250577- Seaweed-derived Bioactive Compounds
- Food Quality and Safety Studies
- Algal biology and biofuel production
- Parkinson's Disease Mechanisms and Treatments
- Skin Protection and Aging
- Aldose Reductase and Taurine
- Echinoderm biology and ecology
- Protein Hydrolysis and Bioactive Peptides
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Phytochemicals and Antioxidant Activities
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- Polysaccharides and Plant Cell Walls
- Marine and coastal plant biology
- Aquaculture Nutrition and Growth
- Antioxidant Activity and Oxidative Stress
- Nutrition, Health and Food Behavior
- Caveolin-1 and cellular processes
- Free Radicals and Antioxidants
- Marine and Coastal Research
- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
- melanin and skin pigmentation
Hanseo University
2019-2024
Jilin Agricultural University
2022
Ajou University
2013-2021
Gachon University
2017-2019
Gachon University Gil Medical Center
2018-2019
University of South Alabama
2019
Deleted Institution
2017
Government of the Republic of Korea
2016-2017
Indiana University School of Medicine
2016
Suwon Research Institute
2016
Microalgae are proposed to have powerful applications for human health in the pharmaceutical and food industries. Tetraselmis species (sp.), which green microalgae, were identified as a source of broad-spectrum health-promoting biological activities. However, bioactivity these has not been elucidated. We aimed confirm antioxidant, antiviral, anti-inflammatory effects sp. extract (TEE). TEE showed 2,2-diphenyl-1-picryl-hydrazyl-hydrate radical hydrogen peroxide scavenging activities reduced...
Abstract In order to find new anti‐browning and whitening agents in this study, we investigated 43 indigenous marine algae for tyrosinase inhibitory activity. The extracts from Endarachne binghamiae , Schizymenia dubyi Ecklonia cava (EC) Sargassum silquastrum (SS) evidenced potent activity similar that of positive control, kojic acid. Among those algae, EC SS are distributed abundantly on Jeju Island. Therefore, selected two species further studies. Our results both reduced cellular melanin...
Abstract Parkinson’s disease (PD) is a common chronic and progressive neurodegenerative disorder. Although the cause of PD still poorly understood, mutations in many genes including SNCA , parkin PINK1 LRRK2 DJ-1 have been identified familial forms PD. It was recently proposed that alterations lipid rafts may neurodegeneration shown Here, we observe deficiency decreased expression flotillin-1 (flot-1) caveolin-1 (cav-1), main protein components rafts, primary astrocytes MEF cells. As...
Recent evidence of prion-like propagation α-synuclein (α-syn) into neighboring neurons set up a paradigm to elucidate the mechanism progression Parkinson's disease (PD) and develop therapeutic strategies. Here, we show that FcγRIIB expressed in functions as receptor for α-syn fibrils mediates cell-to-cell transmission α-syn. SHP-1 2 are activated downstream by through play an important role Also, taking advantage co-culture system, induces intracellular Lewy body-like inclusion body...
Parkinson's disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. While most PD sporadic nature, a significant subset can be linked to either autosomal dominant or recessive mutations. PARK2, encoding the E3 ubiquitin ligase, parkin, frequently mutated gene early onset PD. It has recently been reported that PD-associated products such as PINK1, α-synuclein, LRRK2, and DJ-1, well parkin associate with lipid rafts, suggesting...
Diabetic nephropathy is the leading cause of end-stage renal disease in patients with diabetes mellitus. Oxidative stress has been shown to play an important role pathogeneses damage diabetic patients. Here, we investigated protective effect diphlorethohydroxycarmalol (DPHC), which a polyphenol isolated from edible seaweed, Ishige okamurae, on methylglyoxal-induced oxidative HEK cells, human embryonic kidney cell line. DPHC treatment inhibited methylglyoxal- (MGO-) induced cytotoxicity and...
Backgrounds: Melanogenesis, regulated by genetic, hormonal, and environmental factors, occurs in melanocytes the basal layer of epidermis. Dysregulation this process can lead to various skin disorders, such as hyperpigmentation hypopigmentation. Therefore, present study investigated effect ultrasonic-assisted ethanol extract (SHUE) from Sargassum horneri (S. horneri), brown seaweed against melanogenesis α-melanocyte-stimulating hormone (MSH)-stimulated B16F10 murine melanocytes. Methods:...
Antioxidative activities of Chlorophyta and Phaeophyta in Jeju Island were measured by superoxide anion (), hydroxyl radical hydrogen peroxide () DPPH free scavenging assays. Methanolic aqueous extracts the seaweeds prepared at both temperatures, higher (70) room temperature (20), screened for construction an extract bank from Island. A variety showed positive effect against reactive oxygen species (ROS). Especially, Sargassum thunbergii methanolic 70 (70ME, 97.41%), S. fulvellum 20 (20ME,...
The aim of the present study was to evaluate antioxidant activity red algae in Jeju Island.The algal extracts were obtained with MeOH and fresh water at 20 70°C, screened for activities using hydroxyl radical (HO • ), superoxide anion (O 2-), hydrogen peroxide (H 2 O ) DPPH free scavenging assays.Among them, Gracilaria verrucosa methanolic extract 20°C (20ME, 96.85%),G. textorii aqueous (20AE, 88.01%), Grateloupia filicina 20AE (85.35%), Polysiphonia japonica 20ME (94.92%) exhibited highest...
Mutations in DJ-1 (PARK7) are a known cause of early-onset autosomal recessive Parkinson's disease (PD). Accumulating evidence indicates that abnormalities synaptic vesicle trafficking underlie the pathophysiological mechanism PD. In present study, we explored whether is involved CNS function. deficiency impaired endocytosis and reavailability without inducing structural alterations synapses. Familial mutants (M26I, E64D, L166P) were unable to rescue defective vesicles, whereas WT expression...
Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered greatest risk factor for developing PD. Caveolin-1 (Cav-1) known to participate in process. Recent evidence indicates that prion-like propagation of misfolded α-synuclein (α-syn) released from neurons neighboring plays an important role PD progression. In present study, we demonstrated cav-1 expression brain increased age, and considerably A53T α-syn transgenic mice. Cav-1...
This study was conducted to screen in vitro angiotensin -I converting enzyme (ACE) inhibitory activities of methanol (MeOH) and aqueous extracts at 20°C 70°C, respectively, prepared from twenty-six red algae obtained the coast Jeju Island Korea.Among (20AE) Lomentaria catenata showed strongest ACE activity Lithophyllum okamurae recorded second highest activity.From MeOH extract (20ME) Ahnfeltiopsis flabelliformis possessed activity.Remarkable 70°C (70ME) were observed Grateloupia filicina,...
Abstract Exposure to ultraviolet B (UV‐B) radiation has been associated with a variety of adverse effects in all forms life, including micro‐organisms, plants, animals and humans. Ultraviolet induces cell damage at the molecular level consequently organisms must employ strategies protect themselves from sunlight repair UV‐B‐induced cellular damage. In this study, UV‐B protective four different phlorotannins isolated brown alga ( Ecklonia cava ) were determined using zebrafish Danio rerio as...