A5088561544- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Zebrafish Biomedical Research Applications
- Occupational and environmental lung diseases
- Ovarian cancer diagnosis and treatment
- Biomarkers in Disease Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Cutaneous Melanoma Detection and Management
- Aortic aneurysm repair treatments
- Oral microbiology and periodontitis research
- Protein Hydrolysis and Bioactive Peptides
- Phosphodiesterase function and regulation
- interferon and immune responses
- Extracellular vesicles in disease
- Cancer-related gene regulation
Pusan National University
2019-2025
The tumor microenvironment (TME) within mucosal neoplastic tissue in oral cancer (ORCA) is greatly influenced by tumor-infiltrating lymphocytes (TILs). Here, a clustering method was performed using CIBERSORT profiles of ORCA data that were filtered from the publicly accessible patients with head and neck Cancer Genome Atlas (TCGA) hierarchical where regrouped into binary risk groups based on clustering-measuring scores survival patterns associated individual groups. Based this analysis,...
Prognostic genes or gene signatures have been widely used to predict patient survival and aid in making decisions pertaining therapeutic actions. Although some web-based analysis tools developed, they several limitations.Taking these limitations into account, we developed ESurv (Easy, Effective, Excellent Survival tool), a tool that can perform advanced analyses using user-derived data from The Cancer Genome Atlas (TCGA). Users conduct univariate grouped variable selections multiomics...
Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health homeostasis of individuals. Dysregulation HSPC function can lead to blood-related diseases, including cancer. Despite its importance, our understanding genes pathways underlying development associated pathological mechanisms remains limited. To elucidate these unknown mechanisms, we analyzed databases patients with disorders performed functional gene studies using zebrafish....
Introduction It is well known that the presence of diabetes significantly affects progression periodontitis and has negative effects on diabetes-related complications. Although this two-way relationship between type 2 could be understood through experimental clinical studies, information common genetic factors would more useful for understanding both diseases development treatment strategies. Materials Methods Gene expression data were obtained from Expression Omnibus database. After...
Abdominal aortic aneurysm (AAA), when ruptured, results in high mortality. The identification of molecular pathways involved AAA progression is required to improve prognosis. aim the present study was assess key genes for and their functional role. Genomic clinical data three independent cohorts were downloaded from National Center Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) (GSE57691, GSE7084, GSE98278). To develop diagnosis progression-related differentially expressed...
Abstract Acute myeloid leukaemia (AML) is a blood cancer where undifferentiated cells are increased in the bone marrow and peripheral blood. As AML dangerous shows poor prognosis, many researchers categorised relevant cytogenetic factors according to risk prognosis. However, specific reasons for remain unknown. We analysed large data set from patients found that TPD52 expression elevated patient groups with factors. amino acid sequence of evolutionally conserved vertebrates, zebrafish...
Recent comparative studies have indicated distinct expression profiles of short, non-coding microRNAs (miRNAs) in various types cancer, including oral squamous cell carcinoma (OSCC). In this study, we employed a hybrid approach using Drosophila melanogaster as well OSCC lines to validate putative targets cancer-related miRNAs both vivo and vitro. Following overexpression miR-31, found significant decrease the size imaginal wing discs downregulation subset targets, wntless (wls), an important...
Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In present study, using databases such as TARGET, GSE60926 GSE28460, we determined that KIF2C its binding partner, KIF18B are overexpressed in patients with relapsed compared to diagnosed first time. As 50% residues exactly same signature domain highly conserved between human zebrafish, used zebrafish embryos a model...
Cutaneous melanoma is the most common cause of skin cancer-related deaths worldwide. There an urgent need to identify prognostic biomarkers facilitate decision-making for treatment metastatic cutaneous melanoma. Gene expression microarrays and RNA-seq technology have recently improved or changed current therapeutic strategies several cancers. However, according staging system, prognosis almost entirely dependent on clinicopathological features. To novel biomarkers, we investigated gene...
Non-coding microRNAs (miRNAs) have been proposed to play diverse roles in cancer biology, including epithelial-mesenchymal transition (EMT) crucial for progression.Previous comparative studies revealed distinct expression profiles of miRNAs relevant tumorigenesis and progression oral cancer.With putative targets these mostly validated vitro, it remains unclear whether similar miRNA-target relationships exist vivo.In this study, we employed a hybrid approach, utilizing both Drosophila...
Glioma is the most common primary malignant tumor that occurs in central nervous system. Gliomas are subdivided according to a combination of microscopic morphological, molecular, and genetic factors. Glioblastoma (GBM) aggressive tumor; however, efficient therapies or specific target molecules for GBM have not been developed. We accessed RNA-seq clinical data from The Cancer Genome Atlas, Chinese GSE16011 dataset, identified differentially expressed genes (DEGs) were both lower-grade glioma...
Background/Aim: Since pathways involving LRRC17 are related to the survival of patients with various cancers, we analyzed as a prognostic gene in serous ovarian cancer. Materials and Methods: Data were collected from Gene Expression Omnibus (GSE9891, GSE13876, GSE26712) The Cancer Genome Atlas (TCGA). We performed analyses using C statistics, area under curve, plot optimal cutoff level, cox proportional regression. Zebrafish embryos used an vivo model. Results: prognosis high expression was...
Abstract Background Papillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant tumors. This study focused on identifying targets that affect multifocality PTC. In a previous study, we determined 158 mRNAs related to in BRAF-mutated PTC using The Cancer Genome Atlas. Methods We used multi-omics data (miRNAs and mRNAs) identify regulatory mechanisms investigated mRNAs. miRNA inhibitors were determine relationship between miRNAs. analyzed target...
Malignant pleural mesothelioma (MPM) is a type of cancer characterized by short survival time and poor prognosis. most frequently associated with exposure to asbestos other elongated mineral fibers. The aim this study was examine molecular differences between asbestos-exposed non-exposed MPM patients assess prognostic significances factors. Clinical genetic data were downloaded from Cancer Genome Atlas. To identify the differences, Significant Analysis Microarray method used. Prognostic...
<sec> <title>BACKGROUND</title> Prognostic genes or gene signatures have been widely used to predict patient survival and aid in making decisions pertaining therapeutic actions. Although some web-based analysis tools developed, they several limitations. </sec> <title>OBJECTIVE</title> Taking these limitations into account, we developed ESurv (Easy, Effective, Excellent Survival tool), a tool that can perform advanced analyses using user-derived data from The Cancer Genome Atlas (TCGA). Users...
Colon cancer is one of the most common malignant tumors, but there are still a few validated biomarkers colon cancer. Exosome-mediated microRNAs (miRNAs) have been recognized as potential in cancers, and miRNAs can regulate variety genes. Recently, Fusobacterium nucleatum was discovered tissues human patients. Its role highlighted. F. may contribute to progression through mechanism exosome-mediated transfer. However, exosomal regulation by not well known. Thus, we performed next-generation...
The goal of this study is to develop an FE model for bobbin holders which wind the fiber. It comprised 25 components. Under mechanical assumption, it was simplified and approximated 8 equivalent stiffness three types bearings in a holder were obtained using compression tests. main natural frequency precision without chuck 17.82 ㎐ mode 1 102.95 3. results simulation experimental analysis by modal testing very similar within 2%. To obtain more precise model, optimization 6011 bearing applied...