A5026256793- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- FOXO transcription factor regulation
- Bladder and Urothelial Cancer Treatments
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Enzyme function and inhibition
- BRCA gene mutations in cancer
- Liver Disease Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Kruppel-like factors research
Yonsei University
2016-2025
CHA Bundang Medical Center
2024
CHA University
2024
Gangnam Severance Hospital
2015-2024
University of British Columbia
2015
Korea Institute of Brain Science
2006-2010
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial (EP), by analyzing genomic proteomic data. Molecularly, MP subtype tumors high integrity characterized low mutation rates microsatellite stability, whereas EP integrity. Clinically, the associated with markedly poor survival resistance standard chemotherapy, better sensitivity chemotherapy. Integrative...
Cellular oxygen sensing is required for hypoxia-inducible factor-1alpha stabilization, which important tumor cell survival, proliferation, and angiogenesis. Here we find that terpestacin, a small molecule previously identified in screen of microbial extracts, binds to the 13.4-kDa subunit (UQCRB) mitochondrial Complex III, resulting inhibition hypoxia-induced reactive species generation. Consequently, such blocks factor activation angiogenesis vivo, without inhibiting respiration....
Activation of hepatic stellate cells (HSCs) is a crucial step in the pathogenesis fibrosis. Histone deacetylase (HDAC) an attractive target liver fibrosis because it plays key role gene expression and cell differentiation. We have developed HDAC inhibitor, N-hydroxy-7-(2-naphthylthio)heptanomide (HNHA), investigated anti-fibrotic activity HNHA vitro vivo.We effect on mouse human HSC activation bile duct-ligated (BDL) rats vivo using proliferation assays, cycle analysis, biochemical assay,...
Lactobacillus plantarum has been identified as a probiotic bacterium owing to its role in immune regulation and maintenance of intestinal permeability. Here, we investigated the anti-colitic effects mechanism L. CBT LP3 (LP3). This vivo study was performed using dextran sodium sulfate (DSS) induce colitis mice. Mice were randomly divided into three groups: control supplied with normal drinking water, DSS-treated group followed by oral administration vehicle, gavaged daily for 7 days...
The role of TGF-β1 in lymph node metastasis and lymphangiogenesis, one the most important steps gastric cancer dissemination, is largely unknown. goal this study was to investigate signaling its molecular mechanisms involved lymphangiogenesis cancer.Two cell line models, MKN45 KATOIII, were selected for study. protein expression pathway molecules VEGF-C examined with western blot, or ELISA according treatment. To explore whether Smad3 binds specific DNA sequences VEGFC promoter, we performed...
Abstract Background Cancer cells have developed molecular strategies to cope with evolutionary stressors in the dynamic tumor microenvironment. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) is a metabolic rheostat that regulates diverse cellular adaptive behaviors, including growth and survival. However, mechanistic role of PGC1α regulating cancer cell viability under genotoxic stress remains elusive. Methods We investigated PGC1α-mediated survival mechanisms (i.e.,...
Papillary thyroid cancer (PTC) is a general subtype; however, PTC associated with metastasis or recurrence via anti-cancer drug resistance, rendering it practically incurable. Therefore, effective and reliable clinical approaches are urgently required. We demonstrated the coordinated up-regulation of sarco/endoplasmic reticulum (ER) calcium ATPase 1 (SERCA1) in metastatic under treatment sorafenib lenvatinib. screened novel candidates patient-derived lymph node compared outcomes those...
Anaplastic thyroid cancer (ATC) constitutes less than 2% of total cancers but accounts for 20-40% cancer-related deaths. Cancer stem cell drug resistance represents a primary factor hindering treatment. This study aimed to develop targeted agents against malignancy, focusing on individual and synergistic effects HNHA (histone deacetylase), lenvatinib (FGFR), sorafenib (tyrosine kinase) inhibitors. Patients with biochemically histologically proven papillary (PTC) ATC were included. Cell...
Abstract Purpose: Cancer cells grow in an unfavorable metabolic milieu the tumor microenvironment and are constantly exposed to stress such as chronic nutrient depletion. stem-like (CSC) intrinsically resistant stress, thereby surviving insufficiency driving more malignant progression. In this study, we aimed demonstrate potential mechanisms by which CSCs avoid Ca2+-dependent apoptosis during glucose deprivation. Experimental Design: We investigated cell viability under deprivation,...
Thyroid cancer is generally curable and, in many cases, can be completely treated, although it sometimes recur after therapy. Papillary thyroid (PTC) known as one of the most general subtypes cancer, which take up nearly 80% whole cancer. However, PTC may develop anti-cancer drug resistance via metastasis or recurrence, making practically incurable. In this study, we propose a clinical approach that identifies novel candidates based on target identification and validation numerous...
In the last decade, several tyrosine kinase inhibitors (TKIs), which disrupt pathways involved in proliferation and tumorigenesis of thyroid cancer, have been extensively studied. Two different TKIs, lenvatinib sorafenib, were recently approved by both US FDA European Medicine Agency. Until date, duration TKI response is not sufficient resistance eventually occurs. The goal this study was to investigate a new treatment protocol, SoLAT, using sorafenib alternatively on refractory...
Abstract Background Solid pseudopapillary tumors (SPT) of the pancreas are neoplasms with a low malignant potential. The molecular events contributing to pathogenesis SPTs still unknown. Objectives This study was intended help better understand early steps human SPT development. Methods We microdissected 20 and normal pancreatic tissue. In addition, we examined DNA from each for mutations in exon‐3 β‐catenin loss heterozygosity (LOH) on 9 chromosome arms using 10 microsatellite markers....
Aim: Cholestasis triggers fibrogenesis in the liver. Hepatic cyclooxygenase‐2 (COX‐2) expression increases various chronic liver diseases caused either by viruses or toxins. We hypothesized that selective COX‐2 inhibitor meloxicam could suppress inflammation and a rat model of cholestasis induced bile duct ligation (BDL). Methods: Forty‐three Sprague–Dawley rats were assigned to one four treatment groups (sham‐operation, BDL, daily injections following injection without BDL). Liver...
Recent reports using metabolism regulating drugs showed that nutrient deprivation was an efficient tool to suppress cancer progression. In addition, autophagy control is emerging prevent cell survival. Autophagy breaks down the unnecessary cytoplasmic components into anabolic units and energy sources, which are most important sources for making ATP maintains homeostasis in growth Therefore, glucose analog 2-deoxyglucose (2DG) has been used as anticancer reagent due its inhibition of...
Thyroid cancer has been indicated to have a higher global proportion of DNA methylation and decreased level histone acetylation. Previous studies showed that gene reviser epigenetic changes role significant parts in papillary anaplastic thyroid tumorigenesis. The goal this research was study the endoplasmic reticulum (ER) stress-mediated actions dominant deacetylase (HDAC) inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide (HNHA), explore its effects on apoptotic cell death pathways....
Thyroid cancer is the most well-known type of endocrine that easily treatable and can be completely cured in cases. Nonetheless, anti-cancer drug-resistant metastasis or recurrence may occur lead to failure therapy, which eventually leads death a patient with cancer. This study aimed detect novel thyroid target candidates based on validating identifying one many targets patient-derived sorafenib-resistant papillary (PTC). We focused targeting sarco/endoplasmic reticulum calcium ATPase...
Anaplastic thyroid carcinoma (ATC) although rare is the most deadly form of cancer. The fatality rate for ATC high-pitched, survival at 1 year after diagnosis <20%. Control severely hard and widespread with unpredictability. We Previous proved that histone gene reviser epigenetic changes role significant parts in papillary anaplastic cancer tumorigenesis. Herein, goal this study was to investigate anti-tumor activities a HDAC inhibitor, HNHA alone combination sorafenib cells vitro vivo...
Triggering receptor expressed on myeloid cells 1 (TREM-1)-expressing intestinal macrophages are significantly increased in the colons of patients with inflammatory bowel disease (IBD). We focused here effects guggulsterone macrophage modulation colitis as a potential therapeutic molecule human IBD and explore underlying mechanisms. Gene expression was examined wound-healing assay using HT-29 performed. Colitis wild-type IL-10-, Toll-like 4 (TLR4)-, differentiation primary response 88...
Advanced cancer has been shown to be associated with a higher percentage of epigenetic changes than genetic mutations. Preclinical models have that the combination paclitaxel, sorafenib, and radiation therapy (RT) plays crucial role in renal cell carcinoma (RCC) breast cancer. This study aimed investigate involvement mitochondrial cytochrome c-dependent apoptosis mechanism action RT RCC lines were exposed paclitaxel sorafenib alone or combined presence radiation, viability was determined...
Tumor microenvironments are characterized by decreased oxygen and nutrition due to the rapid progressive nature of tumors also stresses induced several anti-tumor therapies. These intense cell stressors trigger a protective survival mechanism heralded unfolded protein response (UPR). The UPR is an accumulation proteins in endoplasmic reticulum (ER) following starvation. Although ER stress implicated cytoprotection, its precise role during anti-angiogenic therapy remains unclear. One major...
The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide. PTC is the most common type differentiated cancer and usually shows good prognosis. However, some driven to advanced stage by epithelial-mesenchymal transition (EMT)-mediated drug resistance, which particularly noticeable in pediatric patients. There are limited options for systemic treatment, necessitating development new clinical approaches. Here, we aimed clarify genetic differences due age patients with...
Thyroid cancer (TC) includes tumors of follicular cells; it ranges from well differentiated TC (WDTC) with generally favorable prognosis to clinically aggressive poorly (PDTC) and undifferentiated (UTC). Papillary thyroid (PTC) is a WDTC the most common type that comprises almost 70-80% all TC. PTC can present as solid, cystic, or uneven mass originates normal tissue. Prognosis excellent, an overall 10-year survival rate >90%. However, more than 30% patients advance recurrence metastasis...
Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone can result dysregulation cell growth, leading to neoplastic transformation death. Renal tumors have been shown higher global methylation percentage reduced acetylation. Preclinical models revealed that gene modifiers epigenetic alterations important roles renal carcinoma (RCC) tumorigenesis. Recently, novel HDAC inhibitor,...
Abnormal tumor cell metabolism is a consequence of alterations in signaling pathways that provide critical selective advantage to cancer cells. However, systematic characterization the metabolic and altered stem-like cells (CSCs) currently lacking. Using nuclear magnetic resonance mass spectrometry, we profiled whole-cell metabolites pair parental (P-231) (S-231), then integrated with whole transcriptome profiles. We identified elevated NAAD+ S-231 along coordinated increased expression...