A5066039323- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Renal and related cancers
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- Colorectal Cancer Treatments and Studies
- Genomics and Rare Diseases
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
Peter Doherty Institute
2025
The University of Melbourne
2025
Agency for Science, Technology and Research
2020-2025
Genome Institute of Singapore
2017-2025
Abstract Immune evasion is key to cancer initiation and later at metastasis, but its dynamics intermediate stages, where potential therapeutic interventions could be applied, undefined. Here we show, using multi-dimensional analyses of resected tumours, their adjacent non-tumour tissues peripheral blood, that extensive immune remodelling takes place in patients with stage I III hepatocellular carcinoma (HCC). We demonstrate the depletion anti-tumoural subsets accumulation immunosuppressive...
The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome 2. COVID-19 was first reported in China (December 2019) and now prevalent across the globe. Entry of 2 into mammalian cells requires binding viral Spike (S) proteins to angiotensin-converting enzyme receptor. Once entered, S protein primed a specialized serine protease, transmembrane protease host cell. Importantly, besides symptoms that are consistent with other common virus infections...
Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying enhanced stemness understanding developmental requirements of broad clinical therapeutic interest. Here, we demonstrate that during acute infection, the transcriptional regulator inhibitor DNA binding 3 (ID3) identifies stem-like uniquely adapted generate precursors exhausted (Tpex) response chronic infection or...
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, which applies ML next-generation generated from freeze-viable biobank patient-derived primary cell lines (PDCs). These PDCs are screened against 84 Food and Drug Administration (FDA)-approved drugs at clinically relevant doses (Cmax), focusing colorectal...
Abstract We present a novel framework combining single‐cell phenotypic data with transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response. developed pairwise, tumor‐immune discretized interaction assay between natural killer (NK‐92MI) cells and patient‐derived head neck squamous cell carcinoma (HNSCC) lines on microfluidic cell‐trapping platform. Furthermore we generated deep‐learning computer vision algorithm that is capable of automating the...
Introduction Despite recent advances in immunotherapy for hepatocellular carcinoma (HCC), the overall modest response rate underscores need a better understanding of tumor microenvironment (TME) HCC. We have previously shown that CD38 is widely expressed on tumor-infiltrating leukocytes (TILs), predominantly CD3 + T cells and monocytes. However, its specific role HCC TME remains unclear. Methods In this current study, we used cytometry time-of-flight (CyTOF), bulk RNA sequencing sorted...
Summary The recent pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). COVID-19 was first reported in China (December 2019) and now prevalent ∼170 countries across the globe. Entry SARS-CoV-2 into mammalian cells require binding viral Spike (S) proteins to ACE2 (angiotensin converting enzyme 2) receptor. Once entered S protein primed a specialised serine protease, TMPRSS2 (Transmembrane Serine Protease host cell. Importantly, beside...
ChronQC is a quality control (QC) tracking system for clinical implementation of next-generation sequencing (NGS). generates time series plots various QC metrics to allow comparison current runs historical runs. has multiple features data including Westgard rules validity, laboratory-defined thresholds and observations within specified period. Users can record their notes corrective actions directly onto the long-term recordkeeping. facilitates regular monitoring NGS enable adherence high...