A5087769129- RNA regulation and disease
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Cytomegalovirus and herpesvirus research
Nanyang Technological University
2022-2024
Genome Institute of Singapore
2023-2024
Agency for Science, Technology and Research
2023
Abstract We present a novel framework combining single‐cell phenotypic data with transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response. developed pairwise, tumor‐immune discretized interaction assay between natural killer (NK‐92MI) cells and patient‐derived head neck squamous cell carcinoma (HNSCC) lines on microfluidic cell‐trapping platform. Furthermore we generated deep‐learning computer vision algorithm that is capable of automating the...
Abstract Background Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos an activity that unwinds RNA duplexes. However, scope of A-to-I editing by enzymes remains underexplored. Results Here, we identify millions events with high accuracy systematically map editome across developmental stages, adult organs, species. We report diverse spatiotemporal patterns deamination highest early...