A5091371424- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- PARP inhibition in cancer therapy
- Intestinal and Peritoneal Adhesions
- Enhanced Recovery After Surgery
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Hernia repair and management
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Multimodal Machine Learning Applications
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cancer survivorship and care
- Circular RNAs in diseases
Samsung Medical Center
2007-2025
Sungkyunkwan University
2007-2025
Seoul National University Bundang Hospital
2024-2025
Ewha Womans University
2010-2024
Yonsei University
2013-2023
Gynecologic Oncology Group
2023
Severance Hospital
2023
Stanford University
2019-2022
Weatherford College
2021
Yamaguchi University
2021
Introduction We aimed to predict platinum sensitivity using routine baseline multimodal magnetic resonance imaging (MRI) and established clinical data in a radiomics framework. Methods evaluated 96 patients with ovarian cancer who underwent MRI laboratory tests between January 2016 December 2020. The diffusion-weighted, contrast-enhanced T1-weighted, T2-weighted MRI. Subsequently, 293 radiomic features were extracted by manually identifying tumor regions of interest. subjected the least...
The Korean Society of Gynecologic Oncology has updated its clinical practice guidelines for endometrial cancer to incorporate advancements in recent high-quality randomized controlled trials. These address evolving treatment paradigms, and are tailored the medical context. Key updates include a strong recommendation doxorubicin/trabectedin combination therapy metastatic or recurrent unresectable leiomyosarcoma based on significant survival benefits demonstrated trial. For advanced cancer,...
Since coronavirus disease 2019 (COVID-19) vaccination began, abnormal uterine bleeding (AUB) has occurred at a high rate. This study assessed the association between COVID-19 and AUB. In this retrospective cohort study, we analyzed mobile application data on menstrual cycles to investigate differences in prevalence, duration, amount of intermenstrual (IMB) after vaccination. We also duration menstruation, cycle length, associated symptoms Additionally, investigated prevalence IMB according...
Abstract: Background/Objectives: Single-port access (SPA) laparoscopic surgery has gained popularity due to its cosmetic benefits and reduced postoperative pain. However, concerns persist regarding the increased risk of adhesions larger umbilical incision. This study aims contribute personalized medicine by evaluating effectiveness applying an anti-adhesive agent (Guardix SG®, HanmiPharmaceutical Co., Ltd., Seoul, Korea) at incision identifying patient-specific factors for adhesion formation...
Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits use for cancer therapy. In this study, we investigated the effect of FZ with different drug delivery methods on epithelial ovarian (EOC) in both vitro and vivo models.EOC cell lines were treated proliferation was assessed. The tumor growth line xenograft mouse model EOC examined according to route, including oral intraperitoneal administration. To improve systemic by converting fat-soluble drugs...
Surgery for gynecologic malignancy via midline-laparotomy leads to severe postoperative pain. Adequate pain control while sparing opioid consumption does offer benefits in complications and recovery. Intrathecal morphine (ITM) provides simple effective analgesia. In this randomized trial, we compared patients who received either ITM or a sham procedure.
This study was to investigate the frequency of mismatch repair deficiency/high microsatellite instability (MMRd/MSI-H) in gynecologic malignancies and efficacy immune checkpoint inhibitors (ICIs) patients with recurrent cancers according MMR/MSI status.We conducted a multi-center retrospective review on who were diagnosed between 2015 2020. Their clinicopathologic information, results immunohistochemistry staining for MLH1/MSH2/MSH6/PMS2 MSI analysis, tumor response treatment ICIs...
Eric Mitchell, Joseph Noh, Siyan Li, Will Armstrong, Ananth Agarwal, Patrick Liu, Chelsea Finn, Christopher Manning. Proceedings of the 2022 Conference on Empirical Methods in Natural Language Processing. 2022.
In the 2023 series, we summarized major clinical research advances in gynecologic oncology based on communications at conference of Asian Society Gynecologic Oncology Review Course. The review consisted 1) Endometrial cancer: immune checkpoint inhibitor, antibody drug conjugates (ADCs), selective inhibitor nuclear export, CDK4/6 inhibitors WEE1 poly (ADP-ribose) polymerase (PARP) inhibitors. 2) Cervical surgery low-risk early-stage cervical cancer, therapy for locally advanced stage and...
Ovarian cancer, a leading cause of cancer-related deaths in women, remains formidable challenge, especially the context platinum-resistant disease. This study investigated potential benzimidazole derivative BNZ-111 as novel treatment strategy for ovarian cancer.
Abstract The present study was conducted to report the perioperative outcomes of single-port access (SPA) laparoscopic gynecologic surgeries with focus on incidence postoperative incisional hernia from our cumulative data 2498 patients. A retrospective review performed women who had received SPA 2008 2018. Patient characteristics and including were analyzed. There Korean patients for various diseases. median age 40.3 ± 9.2 years, mean body mass index (BMI) 22.6 3.2 kg/m 2 . total 3 occurred...
Single-port access (SPA) laparoscopic surgery and vaginal natural orifice transluminal endoscopic (vNOTES) have many advantages. The objective of the present study is to compare patient characteristics, operative details, postoperative outcomes between two surgical methods. Patients who were planned undergo vNOTES or SPA April 2020 June 2021 prospectively enrolled. method was determined by a single surgeon after imaging results evaluation physical exam. Those had favorable pelvic conditions...
Objective: To evaluate feasibility and safety of hysterectomy adnexal procedures by vaginal natural orifice transluminal endoscopic surgery (vNOTES). Study Design: This is a prospective observational study at tertiary center teaching University hospital. We enrolled prospectively 34 patients with benign diseases sequentially. Results: measured baseline characteristics, surgical data, pain score (VAS) after surgery. surveyed before/after The time port installation each stage was measured....
Abstract Objective To evaluate a psychometric validation of the endometrial cancer subscales (EnCS) in Functional Assessment Cancer Therapy‐Endometrial (FACT‐EN) among patients with cancer. Methods This cross‐sectional study was conducted at tertiary university‐based hospital South Korea between April and October 2022. Participants completed survey questionnaire that included FACT‐EN. Exploratory confirmatory factor analyses (EFA, CFA) reliability were measured using intraclass correlation...
In Brief BACKGROUND: Unscarred uterine rupture in association with systemic lupus erythematosus (SLE) and long-term steroid treatment is rare. CASE: A 36-year-old primigravid woman conceived a twin gestation after vitro fertilization therapy. At 23 weeks of gestation, she was found to have spontaneous the uterus. Her medical history significant for SLE duration 19 years, her condition had been maintained prednisolone. She no scarring or other known risk factors rupture. The fundus main...
This study aimed to evaluate the prognostic significance of tumor regression rate according radiation phase and histologic subtype in patients with locally advanced cervical cancer (LACC) treated chemoradiation. We retrospectively reviewed medical records 398 FIGO stage IIB-IVA concurrent chemoradiotherapy (CCRT) between 2001 2019. Tumor response was assessed using serial magnetic resonance imaging (MRI) at three time points: pre-treatment, post-external beam radiotherapy (EBRT),...
Background: The enhanced recovery after surgery (ERAS) protocols have been consistently associated with improved patient experience and surgical outcomes. Despite the release of ERAS Society guidelines specific to gynecologic oncology, adoption in gynecology on global level has disappointingly low some centers shown minimal improvement clinical outcomes adopting ERAS. aim this study is describe development early at an urban academic tertiary medical center. Methods: This was observational...
To report our experience of implementing non-invasive prenatal testing (NIPT) in a tertiary urban academic medical center South Korea. An observational retrospective study singleton and twin pregnancies that underwent screening for fetal aneuploidy from July 2016 to April 2018 was conducted. Demographics the population electing NIPT versus those opting integrated test were compared. We also assessed clinical significant factors influencing cfDNA fraction NIPT. Among 817 women who serum tests...