A5085997912- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- RNA modifications and cancer
- FOXO transcription factor regulation
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Cancer Mechanisms and Therapy
- Single-cell and spatial transcriptomics
- Menopause: Health Impacts and Treatments
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- Cancer Risks and Factors
- Reproductive Biology and Fertility
- ATP Synthase and ATPases Research
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Phosphodiesterase function and regulation
- Kruppel-like factors research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Ion Channels and Receptors
Inje University Sanggye Paik Hospital
2023-2025
Community Link
2025
Kyung Hee University Hospital at Gangdong
2017-2023
Yonsei University
2018-2023
Severance Hospital
2019-2020
Gangnam Severance Hospital
2018-2020
National Institutes of Health
2020
National Cancer Institute
2020
Center for Cancer Research
2020
To evaluate the association between various regimens and combinations of menopausal hormone therapy (MHT) risk cardiovascular disease (CVD) in clinical practice. This was a population-based cohort study. study used data from Health Insurance Review Assessment Service. The women who reported entering menopause at ≥40 years age with no history CVD national health examination 2011 2014 were extracted. A total 134 298 pairs included MHT non-MHT groups after 1:1 propensity score matching....
SummaryThe origins of epithelial ovarian cancer (EOC) have long been debated, with proposed sources including surface (OSE) cells, secondary Müllerian tract structures, or fallopian tube epithelium. Despite being the second most common gynecological and a leading cause death in United States, vitro cell models mimicking normal cells their malignant counterparts are lacking. To address this gap, we established immortalized human OSE (IHOSE) lines that demonstrate stable growth without...
<h3>Abstract</h3> Background/Aim: This study investigated the relationship between E-cadherin down-regulation and enhanced pERK1/2 signaling in cervical cancer, evaluated their combined prognostic impact, explored potential therapeutic targets. Materials Methods: We analyzed 188 cancer specimens 300 normal tissue samples using microarray immunohistochemistry. Small interfering RNA transfection western blotting were used to molecular interactions cell lines. Results: observed a significant...
Journal Article Accepted manuscript Response by Yuk et al to Letter Regarding Article, "Association of menopausal hormone therapy with risk cardiovascular disease in Korean women" Get access Jin-Sung Yuk, MD, PhD, PhD Department Obstetrics and Gynecology, Sanggye Paik Hospital, School Medicine, Inje University, Seoul, Republic Korea Search for other works this author on: Oxford Academic Google Scholar Gwang Sil Kim, MD Division Cardiology, Internal University College Dong-Gil Young Sup Byun,...
OBJECTIVE: To investigate the association between duration of levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer risk in Korean women. METHODS: A retrospective cohort study was conducted using National Health Insurance Claims database from 2013 to 2022. total 2,094,029 women aged 30–49 years with initial diagnoses endometriosis, uterine leiomyomas, or abnormal bleeding 2014 2017 were included study. Propensity score matching applied create balanced cohorts LNG-IUS...
To analyze the relationship between pelvic organ prolapse (POP) and menopausal hormone therapy (MHT). This retrospective cohort study used Korean National Health checkup insurance data from 2002 to 2019. The MHT group consisted of women who were prescribed hormones for more than 6 months 2011. non-MHT comprised postmenopausal had never MHT. In group, there 1,001,350 women, while 353,206 women. Tibolone (adjusted hazard ratio [aHR], 0.87; 99% confidence interval [CI], 0.818-0.926) combined...
Problem Preeclampsia ( PE ) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed investigate the clinical effectiveness of platelet‐to‐lymphocyte ratio PLR in women with compare this measurement platelet indices as diagnostic prognostic marker . Method study A total 471 healthy pregnant women, 126 diagnosed mild , 227 severe were included retrospective study. analyzed indices, mainly mean volume MPV distribution width PDW among 3 groups....
Background Human ovarian surface epithelial (HOSE) cells are a critical cell source for cancer research; however, they difficult to obtain and maintain under standard laboratory conditions in large quantities. The aim of this study was generate immortalized HOSE (IHOSE) with maintained properties the original source, thereby guaranteeing sufficiently quantity research. Methods isolated from four non-cancer patients five IHOSE lines were established by induction HPV-E6/E7 expression or SV40 T...
Stromal and immune cells in the tumor microenvironment (TME) have been shown to directly affect high-grade serous ovarian cancer (HGSC) malignant phenotypes, however, how these interact influence HGSC patients’ survival remains largely unknown. To investigate cell-cell communication such a complex TME, we developed SpatioImageOmics (SIO) pipeline that combines imaging mass cytometry (IMC), location-specific transcriptomics, deep learning identify distribution of various stromal, as well...
In the 2023 series, we summarized major clinical research advances in gynecologic oncology based on communications at conference of Asian Society Gynecologic Oncology Review Course. The review consisted 1) Endometrial cancer: immune checkpoint inhibitor, antibody drug conjugates (ADCs), selective inhibitor nuclear export, CDK4/6 inhibitors WEE1 poly (ADP-ribose) polymerase (PARP) inhibitors. 2) Cervical surgery low-risk early-stage cervical cancer, therapy for locally advanced stage and...
The prognostic role of USP10 in epithelial ovarian cancer has been studied various human cancers. Our aim was to evaluate the clinical and pathological significance cancer.Immunohistochemical analyses expression p14ARF by using tissue microarrays were performed 336 tumours data compared with clinicopathological variables. We examined their level DNA methylation around putative transcriptional start site 5' CpG islands fresh frozen tissues cells.Expression significantly lower than normal...
Abstract Background Transcription factors forkhead box protein O1 (FOXO1) and paired 3 (PAX3) have been reported to play important roles in various cancers. However, their role epithelial ovarian cancer (EOC) has not elucidated yet. Therefore, we evaluated the expression clinical significance of FOXO1 PAX3 EOC. Methods Immunohistochemical analyses 212 EOCs, 57 borderline tumors, 153 benign 79 nonadjacent normal tissues were performed using tissue microarray. Various clinicopathological...
Purpose: Modulated electro-hyperthermia (mEHT), known as oncothermia, is an anticancer therapy that induces radiofrequency thermal damage to the cancer tissues. This study aimed evaluate potential effectiveness of mEHT a therapeutic tool in ovarian and cervical cancer.Materials methods: We used both tumor-bearing mice OVCAR-3, SK-OV-3, HeLa SNU-17 cell lines investigate effects vivo vitro, respectively, determine whether it was enhanced by cotreatment with autophagy inhibitor.Results:...
The presence of intracavitary cardiac metastasis from squamous cell carcinoma the uterine cervix is extremely rare. diagnosis made almost exclusively postmortem. Apart causing intracardiac obstruction, it can present as pulmonary emboli and prognosis poor. It important to suspect this in patient with recurrent emboli. Due rarity condition very difficult standardize care for these patients. However, possible that aggressive therapy may lengthen patients' survival quality life. We a case...
Transient receptor potential vanilloid type 1 (TRPV1) has been reported to play an important role in human cancers. However, the knowledge about TRPV1 cervical cancer is sparse. Therefore, we evaluated expression and clinical significance of cancer. Immunohistochemical analyses were performed for phosphatase tension homolog (PTEN) delineate using 150 cancers, 230 intraepithelial neoplasias, 312 normal epithelial tissues a tissue microarray. Furthermore, cell growth was assessed line. The...
Background: Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but not epithelial ovarian cancer (EOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase tension homolog (PTEN) EOC. Materials Methods: Immunohistochemical analyses for PTEN were performed using a tissue microarray. Moreover, role cell growth was assessed EOC line. Results: High expression combination high low an independent prognostic factor...
Rationale: Spontaneous and repeated hepatic ruptures caused by hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome are uncommon but life-threatening conditions that rarely occur early in the second trimester of pregnancy. Patient concerns: We describe a patient who experienced spontaneous absence hypertension during trimesters both her first pregnancies. Diagnoses: A 34-year-old multiparous woman without was admitted at 21 weeks’ gestation because rupture with hemoperitoneum....
The vacuolar ATPase H+ transporting V1 subunit B1 (ATP6V1B1) belongs to the family of ATP6Vs, which functions transport hydrogen ions. expression ATP6V1B1 and associated clinicopathological features have been linked various cancers; however, its role in epithelial ovarian cancer (EOC) has remained be explored. present study aimed unveil function, molecular mechanisms clinical significance EOC. mRNA levels ATP6V1 subunits A, B2 EOC tissues were determined using data from Gene Expression...