A5064681966- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Sodium Intake and Health
- Parathyroid Disorders and Treatments
- Renal function and acid-base balance
- Hemoglobinopathies and Related Disorders
- Central Venous Catheters and Hemodialysis
- Renal and Vascular Pathologies
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Vascular Procedures and Complications
- Acute Kidney Injury Research
- Diet and metabolism studies
- Liver Disease and Transplantation
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Cardiac Imaging and Diagnostics
Eulji University
2014-2024
National University College
2022
New Generation University College
2022
Pusan National University Hospital
2022
Seoul National University
2022
Chonnam National University Hospital
2022
Inje University Busan Paik Hospital
2022
Seoul National University Hospital
2022
Eulji General Hospital
2008-2021
Ansan University
2018-2021
Background. Although neutrophils and T cells are important in mediating renal injury following ischaemia/reperfusion, the role of macrophages is still unknown. Using liposomal clodronate (LC), we investigated effect systemic monocyte–macrophage depletion on damage ischaemic acute failure rats. Methods. Male Sprague–Dawley rats were injected by LC or vehicle underwent bilateral pedicle clamping (40 min) sham ischaemia. Biochemical histological was assessed gene expression kinetics tumour...
Abstract The prevalence of hyperuricemia and chronic kidney disease (CKD) has been steadily increasing. role efficacy uric acid-lowering agents against CKD progression remain controversial. This study aimed to evaluate the effect on CKD. A total 2042 patients with were analyzed in KoreaN cohort Study for Outcomes With Chronic Kidney Disease (KNOW-CKD), a prospective study. Patients classified into quartiles basis their serum acid level advanced was higher high level. composite renal outcome...
With Chronic Kidney Disease (KNOW-CKD)Anemia is a common and significant complication of chronic kidney disease (CKD).However, its prevalence current management status has not been studied thoroughly in Korea.We examined the anemia, association with clinical laboratory factors, utilization iron agents erythropoiesis stimulating using baseline data from large-scale CKD cohort defined anemia when hemoglobin level was lower than 13.0 g/dL males 12.0 females, or received by agents.Overall 45.0%...
An elevated coronary artery calcification score (CACS) is associated with increased cardiovascular disease risk in patients CKD. However, the relationship between CACS and CKD progression has not been elucidated.
Macrophages have been thought to play a role in renal tubulointerstitial fibrosis; recent reports demonstrated an antifibrotic effect of macrophages late-stage fibrosis. Liposome-encapsulated clodronate (LC) produces selective and systemic depletion phagocytic vivo. To study the initial infiltrating fibrosis, we compared effects pretreatment with LC liposome vehicle for control severity fibrosis unilateral ureteral obstruction (UUO) rat model.One day after single intravenous injection or...
Fibroblast growth factor-23 (FGF23) is an established biomarker of adverse outcomes in patients with chronic kidney disease (CKD). Several cross-sectional studies have suggested a possible association between FGF23 and anemia these patients. In this large-scale prospective cohort study, we investigated relationship examined whether high levels increase the risk incident anemia. This longitudinal study included 2,089 from KoreaN for Outcome With CKD. Anemia was defined as hemoglobin level...
Background High-density lipoprotein cholesterol ( HDL -C) levels are generally decreased in patients with chronic kidney disease CKD ). However, studies on the relationship between -C and progression scarce. Methods Results We studied association serum risk of 2168 participants KNOW - (Korean Cohort Study for Outcome Patients With Chronic Kidney Disease). The primary outcome was composite a 50% decline estimated glomerular filtration rate from baseline or end-stage renal disease. secondary...
Abstract Background Diet is a modifiable factor of chronic kidney disease (CKD) progression. However, the effect dietary salt intake on CKD progression remains unclear. Therefore, we analyzed renal outcome in Korean patients with CKD. Methods We measured 24-h urinary sodium (Na) excretion as marker prospective, multi-center, longitudinal KoreaN cohort study for Outcome With (KNOW-CKD). Data were from at Stages G3a to G5 (n = 1254). investigated association between and Patients divided into...
Abstract We investigated potential nosocomial aerosol transmission of severe fever with thrombocytopenia syndrome virus (SFTSV) droplet precautions. During generating procedures, SFTSV was be transmitted from person to through aerosols. Thus, airborne precautions should added standard avoid direct contact and transmission.
Abstract The clinical importance of serum hepcidin in non-dialysis chronic kidney disease (CKD) patients is unclear. database a large-scale multicentre prospective study Korea 2238 enrolled from 2011–2016 was analysed. After excluding with missing (n = 125) and haemoglobin 23) levels, the included 2090 CKD patients. Markers inflammation iron status were positively associated level, regardless stage. However, estimated glomerular filtration rate inversely particularly stages 3b–5 but not...
Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, closely associated with CKD. Each component of MS and klotho has an association. However, little known about the association between per se. We investigated serum levels using baseline cross-sectional data obtained from large Korean CKD cohort. Of 2238 subjects recruited KoreaN Cohort Study for Outcome Patients With Chronic Kidney Disease (KNOW-CKD) 2011 2016, 484 patients missing on...
Background and objectives Sleep duration has been associated with cardiometabolic risk mortality. The health-related quality of life represents a patient’s comprehensive perception health is accepted as outcome. We examined the relationship between sleep in predialysis CKD. Design, setting, participants, & measurements In this cross-sectional study, data from 1910 adults CKD enrolled Korean Cohort Study for Outcome Patients were analyzed. Health-related was assessed physical component...
The present study aimed to determine the role of cystatin C as a prognostic factor for acute kidney injury and survival in cirrhotic patients.The investigated 53 liver cirrhosis patients. renal function was evaluated by serum creatinine, urine C, 24-hour creatinine clearance on admission. Acute defined level exceeding normal range (>1.2 mg/dl) an increase at least 50% from baseline value. Multivariate analysis, receiver operating characteristic curve, analysis were used investigate factors...
Abstract Metabolic acidosis is common in chronic kidney disease (CKD) and may have various deleterious consequences. Arterial stiffness CKD patients associated with poor cardiovascular outcomes. The present study aimed to evaluate the association between serum bicarbonate arterial using baseline cross-sectional data set of a large-scale Korean cohort. 2,238 were enrolled KoreaN Cohort Study for Outcome Patients With Chronic Kidney Disease (KNOW-CKD) from 2011 2016. was conducted on 1,659...
Abstract Few studies have investigated the incidence of cardiovascular disease (CVD) in Asian chronic kidney (CKD) population. This study assessed CVD, death, and a composite outcome CVD death prospective Korean predialysis CKD cohort. From total 2179 patients, rates were analyzed, competing risk analyses conducted according to stage. Additionally, was compared general During median 4.1 years follow-up, all-cause 17.2, 9.6, 24.5 per 1000 person-years, respectively. These values higher...
Abstract This study aimed to evaluate changes in health-related quality of life (HRQOL) patients with chronic kidney disease (CKD) according decline function. HRQOL was assessed using the Short Form-36 questionnaire composed a physical component summary (PCS) and mental (MCS). Rapid function defined as estimated glomerular filtration rate (eGFR) > 3 mL/min/1.73 m 2 /year. deterioration change value greater than median. Among 970 patients, 360 (37.1%) were rapid group. In 720 who 1:1...
Abstract The causes of chronic kidney disease (CKD) affects its outcomes. However, the relative risks for adverse outcomes according to specific CKD is not well established. In a prospective cohort study from KNOW-CKD, was analyzed using overlap propensity score weighting methods. Patients were grouped into four categories cause CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive (HTN), or polycystic (PKD). From total 2070 patients, hazard ratio failure, composite...
Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney (CKD). We report baseline cardiovascular characteristics 2,238 participants by using data KoreaN Cohort Study for Outcomes Patients With Chronic Kidney Disease (KNOW-CKD) study. The cohort comprises 5 subcohorts according to CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive (HTN), polycystic (PKD), and unclassified. average estimated glomerular filtration rate (eGFR) was 50.5 ±...
Elevated blood pressure and intrarenal renin-angiotensin system activity are closely related to chronic kidney disease (CKD) progression. However, interrelationship between on the risk of CKD progression is unknown.We analyzed 2076 participants from Korean Cohort Study for Outcomes in Patients With CKD. The main exposure was systolic (SBP). urinary angiotensinogen-to-creatinine ratio stratified according median value (3.65 μg/gCr). primary outcome a composite ≥50% decline estimated...