A5021120955- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Renal function and acid-base balance
- Iron Metabolism and Disorders
- Birth, Development, and Health
- Cardiovascular Health and Risk Factors
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Nutritional Studies and Diet
- Erythropoietin and Anemia Treatment
- Folate and B Vitamins Research
- Energy and Environment Impacts
- Hemoglobinopathies and Related Disorders
- Complement system in diseases
Yonsei University
2016-2025
Gangnam Severance Hospital
2019-2025
Severance Hospital
2015-2024
Inha University
2018-2019
Kidney Research UK
2017-2019
Ewha Womans University
2017
National Health Insurance Service
2017
Preeclampsia is one of the leading causes maternal and fetal morbidity mortality. Due to lack effective preventive measures, its prediction essential prompt management. This study aimed develop models using machine learning predict late-onset preeclampsia hospital electronic medical record data. The performance based conventional statistical methods were also compared. A total 11,006 pregnant women who received antenatal care at Yonsei University Hospital included. Maternal data retrieved...
The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney fibrosis. However, it unknown whether PGC-1α, a key biogenesis regulator, modulates in injury. Primary renal tubular epithelial cells (RTECs) were isolated from C57BL/6 mice. inflammasome, dynamics morphology, oxidative stress, cell injury markers examined RTECs treated TGF-β1 with or without Ppargc1a plasmid, PGC-1α activator (metformin), siPGC-1α. In vivo, adenine-fed unilateral ureteral obstruction (UUO)...
The effect of a high-protein diet with renal hyperfiltration (RHF) on decline kidney function has rarely been explored. We investigated the association between diet, RHF and declining function.A total 9226 subjects from Korean Genome Epidemiology Study, community-based prospective study (2001-14), were enrolled classified into quartiles according to daily amount protein intake based food frequency questionnaires. was defined as estimated glomerular filtration rate (eGFR) residuals >95th...
Hyperphosphatemia is associated with mortality in patients chronic kidney disease, and common critically ill acute injury (AKI); however, its clinical implication these unknown. We conducted an observational study 1144 (mean age, 63.2 years; male, 705 [61.6%]) AKI who received continuous renal replacement therapy (CRRT) between January 2009 September 2016. Phosphate levels were measured before (0 h) 24 h after CRRT initiation. assessed disease severity using various parameters. at 0...
Depression is reported to be the most common psychological problem in patients with chronic kidney disease (CKD). Several studies have that lower levels of serum vitamin D are significantly associated depression. Both deficiency and depression prevalent CKD, yet relationship between these two factors remains poorly understood. This study aimed investigate association among CKD patients.Totally, 21,257 individuals who participated Korean National Health Nutrition Examination Survey (KNHANES...
Visual Abstract Export Background and objectives Active smoking is associated with higher risk of various diseases. However, the CKD development in nonsmokers exposed to secondhand smoke not well elucidated. We aimed investigate association between exposure among never-smokers. Design, setting, participants, & measurements A total 131,196 never-smokers normal kidney function, who participated Korean Genome Epidemiology Study from 2001 2014, were analyzed. The participants classified into...
This report provides an overview of hypertension prevalence, management, and trends in South Korea. The analysis is based on data from Korean adults aged 20 older, using the 1998-2022 Korea National Health Nutrition Examination Survey (KNHANES) 2002-2022 Insurance (NHI) Big Data. An estimated 30% (13 million) have hypertension, including 7.2 million men, 5.8 women, 65 or older. Overall awareness, treatment, control rates were 77%, 74%, 59%, respectively, showing a tendency to increase with...
Continuous renal replacement therapy (CRRT) is essential in the management of critically ill patients with acute kidney injury (AKI). However, optimal timing for initiating CRRT remains controversial, especially elderly patients. Therefore, we investigated outcomes early initiation AKI.A total 607 ≥65 years age who started due to AKI between August 2009 and December 2013 were prospectively enrolled. They divided into two groups based on median 6-hour urine output immediately before...
Abstract Background Online haemodiafiltration (OL-HDF) may improve middle molecular clearance in contrast to conventional haemodialysis (HD). However, OL-HDF requires higher convective flows and cannot sufficiently remove large molecules. This study evaluated the efficacy of a medium cut-off (MCO) dialyser removing uraemic toxins compared it with that high-flux (HF) dialysers HD predilution OL-HDF. Methods Six clinically stable patients without residual renal function were investigated....
Electrolyte and mineral disturbances remain a major concern in patients undergoing continuous renal replacement therapy (CRRT); however, it is not clear whether those imbalances are associated with adverse outcomes septic acute kidney injury (AKI) CRRT. We conducted post-hoc analysis of data from prospective randomized controlled trial. A total 210 mean age 62.2 years (136 [64.8%] males) 2 hospitals were enrolled. Levels sodium, potassium, calcium, phosphate measured before (0 hour) 24 hours...
Background & aimsPrevious studies have shown that dietary zinc intake is closely related to cardiovascular complications and metabolic derangements. However, the effect of on renal function not fully elucidated.MethodsData from Korean Genome Epidemiology Study were used. Dietary was assessed by a Food Frequency Questionnaire density calculated as absolute amount per daily energy (mg/1000 kcal day). The participants categorized into quartiles according density. primary end point incident...
The aim of this study is to elucidate the effects warfarin use in patients with atrial fibrillation undergoing dialysis using a population-based Korean registry.Data were extracted from Health Insurance Review and Assessment Service, which nationwide, mandatory social insurance database all citizens enrolled National Information Service between 2009 2013. Thromboembolic hemorrhagic outcomes analyzed according use. Overall propensity score-matched cohorts by Cox proportional hazards...
Extracellular fluid (ECF) excess is an independent predictor of cardiovascular morbidity in patients undergoing dialysis. This study aimed to investigate the relationship between ECF status, which affected by renal function, and coronary artery calcification (CAC), a marker disease, with chronic kidney disease (CKD).
Extracorporeal membrane oxygenation (ECMO) is a cardiorespiratory support technique for patients with circulatory or pulmonary failure. Frequently, large-volume fluid resuscitation needed to ensure sufficient extracorporeal blood flow in initiating ECMO. However, excessive overhydration known increase mortality critically ill patients. Therefore, order define tolerant volume range undergoing ECMO treatment, the association between cumulative balance (CFB) and outcome was evaluated ECMO.This...
Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between has been investigated severe cases only. Thus, this study evaluated relationship renal function a community-based prospective cohort comprising mild to moderate disease. A total of 44,938 participants who were participated Korean National Health Nutrition Examination Survey IV, V, VI from 2007 2014 enrolled. Estimated glomerular filtration rate...
Abstract Hypertension is common and contributes to adverse outcomes in patients undergoing dialysis. However, the proper blood pressure (BP) target remains controversial several factors make this difficult. This study aimed investigate adequate BP prevalent Data were retrieved from Clinical Research Center for End-Stage Renal Disease (2009–2014). 2,299 dialysis evaluated. Patients assigned into eight groups according predialysis systolic (SBP). The primary outcome was all-cause mortality....
Abstract Background Obesity, a known risk factor for chronic kidney disease (CKD), is generally assessed using body mass index (BMI). However, BMI may not effectively reflect composition, and the impact of muscle‐to‐fat (MF) balance on function has been elucidated. This study evaluated association between muscle fat balance, represented as MF ratio, incident CKD development. Methods Data were retrieved from prospective community‐based cohort (Korean Genome Epidemiology Study). Muscle...