A5082316302- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Trace Elements in Health
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Inflammatory mediators and NSAID effects
- Protein Degradation and Inhibitors
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects and Toxicity Studies
- Cancer Genomics and Diagnostics
- Mechanisms of cancer metastasis
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
UNSW Sydney
2020-2024
Children's Cancer Institute Australia
2014-2024
QIMR Berghofer Medical Research Institute
2024
Cancer Institute of New South Wales
2020-2024
Children's Hospital at Westmead
2014-2022
Westmead Institute
2019
The University of Sydney
2009-2018
Melanoma Institute Australia
2017
John Hunter Hospital
2017
Royal Prince Alfred Hospital
2017
Abstract Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence cancer cells. Deep analysis The Cancer Genome Atlas database and tissue microarrays showed strong correlation between major influx transporter (CTR-1) across many cancers but not...
Histone chaperone FACT acts in a positive feedback loop with MYCN and is therapeutic target neuroblastoma.
There is no effective treatment for the cardiomyopathy of most common autosomal recessive ataxia, Friedreich ataxia (FA). This disease due to decreased expression mitochondrial protein, frataxin, which leads alterations in iron (Fe) metabolism. The identification potentially toxic Fe deposits FA suggests plays a role its pathogenesis. Studies using muscle creatine kinase (MCK) conditional frataxin knockout mouse that mirrors have demonstrated deletion alters cardiac Indeed, there are...
Iron is critical for cellular proliferation and its depletion leads to a suppression of both DNA synthesis global translation. These observations suggest that iron may trigger "stress response". A canonical response cells stress the formation granules, which are dynamic cytoplasmic aggregates containing stalled pre-initiation complexes function as mRNA triage centers. By differentially prioritizing translation, granules allow continued selective translation proteins. Although multi-subunit...
Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance treatments. Recent studies highlight that elevated levels of copper are implicated in progression metastasis. Clinical trials using chelators associated with improved patient survival; however, the molecular mechanisms by which depletion inhibits tumor metastasis poorly understood. This remains a major hurdle clinical translation chelators. Here, we propose chelation...
It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene–environment and gene–gene interactions. The (case-control nested in EPIC cohort) was established investigate molecular changes genetic susceptibility relation air pollution environmental tobacco smoke (ETS) non-smokers. have analyzed 757 controls 409 cases with bladder...
Iron deficiency affects 500 million people, yet the molecular role of iron in gene expression remains poorly characterized. In addition, alterations global after chelation remain unclear and are important to assess for understanding pathology biological effects chelators. Considering this, we assessed effect on whole genome two chelators (desferrioxamine 2-hydroxy-1-napthylaldehyde isonicotinoyl hydrazone) that have markedly different permeability properties. Sixteen genes were significantly...
Iron plays a crucial part in proliferation while iron deficiency results G1/S arrest, DNA damage, and apoptosis. However, the precise role of cell cycle control remains unclear. We showed that depletion using chelators, desferrioxamine (DFO), or 2-hydroxy-1-napthylaldehyde isonicotinoyl hydrazone (311), increased mRNA levels growth arrest damage 45α gene, GADD45α (Darnell, G. Richardson, D. R. (1999) Blood 94, 781–792). In this study, we examined effect on up-regulating GADD family members...
The (32)P-post-labelling assay has emerged as a major tool for detecting bulky DNA adducts in subjects exposed to carcinogens, especially aromatic compounds. However, the protocol still requires use of high amounts radioactivity, i.e. 25-50 muCi per sample, an obstacle that limits its large studies. characterization measured is also limited. Methodological improvements and increased adduct are necessary make this capable achieving higher throughput. A new was tested ensure efficient...
A diet rich in fruit and vegetables can be effective the reduction of oxidative stress, through antioxidant effects phytochemicals other mechanisms. Protection against carcinogenic chemicals may also exerted by an enhancement detoxification DNA damage repair To investigate a putative effect flavonoids, class polyphenols, on regulation gene expression metabolic genes, 1-month flavonoid-rich was administered to thirty healthy male smokers, nine whom underwent analysis. We postulated that...
Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges their treatment is inter- intra-tumoral heterogeneity. Precision medicine approaches have potential to enhance diagnostic, prognostic and/or therapeutic information. In this case study we describe molecular characterization a pediatric HGG use an integrated approach based on genomic, vitro vivo testing identify actionable targets options. Molecular...
Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, homeostasis is considered as an emerging target for anticancer drug design.Monitoring vivo therefore paramount importance when assessing efficacy copper-targeting drugs.Herein, we investigated activity compound Dextran-Catechin by developing [ 64 Cu]CuCl2 PET imaging protocol to monitor its effect on tumors.Methods: Protein expression transporter 1 (CTR1) tissue microarrays...