A5062504721- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Neuroblastoma Research and Treatments
- PARP inhibition in cancer therapy
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Dental Research and COVID-19
- Chromatin Remodeling and Cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Dental Health and Care Utilization
- Endodontics and Root Canal Treatments
- Computational Drug Discovery Methods
- Dental materials and restorations
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- Chemical Reactions and Isotopes
- Science, Research, and Medicine
- ATP Synthase and ATPases Research
- Dental Erosion and Treatment
- Seaweed-derived Bioactive Compounds
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
Cancer Institute of New South Wales
2020-2025
UNSW Sydney
2019-2025
University of Auckland
2024
Children's Cancer Institute Australia
2020-2024
Kerala University of Health Sciences
2024
Central Marine Fisheries Research Institute
2021
Los Angeles Mission College
2021
Sri Ramachandra Institute of Higher Education and Research
2015
Amrita Vishwa Vidyapeetham
2014
Bhabha Atomic Research Centre
1976-1999
Abstract For one-third of patients with pediatric cancer enrolled in precision medicine programs, molecular profiling does not result a therapeutic recommendation. To identify potential strategies for treating these high-risk patients, we performed vitro screening 125 patient-derived samples against library 126 anticancer drugs. Tumor cell expansion did influence drug responses, and 82% the screens on expanded tumor cells were completed while still under clinical care. High-throughput (HTS)...
Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (FACT), a remodeling complex involved in transcription, replication, DNA repair. We show displays profound cytotoxic activity against panel of patient-derived DIPG cultures by restoring suppressor TP53 Rb activity. Moreover, orthotopic model DIPG, treatment with...
Abstract Background Diffuse midline glioma, characterised by H3K27 alteration (DMG), is the predominant high-grade glioma in children. It commonly originates brainstem, yet effective treatments for these patients remain elusive. Methods To identify novel therapies DMG, we conducted high-throughput drug screens (HTS) using biologically active, clinically approved compounds against DMG neurospheres. Multiple primary cultures were utilised conjunction with vitro cytotoxicity and clonogenic...
An in vitro study to evaluate and compare the remineralization potential of commercially available remineralizing agents containing silver diamine fluoride (SDF), casein sucrose phosphate (CSP), phospho peptide-amorphous calcium (CPP-ACP) using DIAGNOdent.Thirty freshly extracted premolars for orthodontic treatment were collected. Specimens randomly divided into 3 groups 10 each: group I: SDF, II: CSP, III: CPP-ACP. The samples subjected DIAGNOdent analysis recording baseline values. placed...
Glanzmann's thrombasthenia (GT) is a rare, congenital, and moderate to severe platelet disorder. The bleeding time increased, due lack of aggregation, since the patients with GT have deficient or dysfunctional integrin membrane glycoproteins IIb IIIa essential for aggregation. Children are mostly diagnosed very early in life spontaneous unexplained mucocutaneous bleeding. It quite challenging task when any surgery indicated children GT. This case report about medical surgical management an...
Diffuse intrinsic pontine gliomas (DIPG) are an incurable childhood brain cancer for which novel treatments needed. DIPGs characterized by a mutation in the H3 histone (H3K27M), resulting loss of H3K27 methylation and global gene dysregulation. TRX-E-009-1 is anticancer agent with preclinical activity demonstrated against range cancers. We examined antitumor DIPG neurosphere cultures observed tumor-specific IC50s ranging from 20 to 100 nmol/L, whereas no was normal human astrocyte cells....
Abstract Aberrant epigenetic regulation is a hallmark of Diffuse Midline Glioma (DMG), an incurable tumor that primarily arises in the brainstem young children. The H3K27M driver histone mutation and resulting permissive chromatin indicates targeting as key therapeutic strategy against this aggressive cancer. One such target Facilitates Chromatin Transcription (FACT) chaperone. FACT targeted by curaxin compound CBL0137 which currently phase I/II clinical trial for pediatric cancer patients...
Abstract Medulloblastoma is the most common pediatric malignant brain tumor. Polyamines, critical intracellular polycations governing key cell processes such as DNA replication, translation, and proliferation, are frequently upregulated in cancer. We previously showed that polyamine pathway to growth survival of diffuse midline gliomas MYC amplified neuroblastoma. Given activity inhibition DMG, given role medulloblastoma, we sought investigate potential a therapeutic approach for...
The primary intent of this scientific research is to effectively assess and collate the inherent potentiality two selected investigative composite materials in effectual maintenance their standard color following subsequent consistent submersion customary available pediatric liquids consumed by children. above investigation will be estimated using Commission Internationale de I'Eclairege (CIE) L*a*b* system-based spectrophotometer.
Abstract Aberrant epigenetic regulation is a hallmark of Diffuse Midline Glioma (DMG), an incurable pediatric brain tumor. The H3K27M driver histone mutation leads to transcriptional dysregulation, indicating that targeting the epigenome and transcription may be key therapeutic strategies against this highly aggressive cancer. One such target Facilitates Chromatin Transcription (FACT) chaperone. We found FACT enriched at developmental gene promoters, coinciding with regions open chromatin...
Abstract BACKGROUND Polyamines, essential intracellular polycations, govern fundamental cell processes and drive oncogenesis. Our research unveiled the dependency of pediatric Diffuse Midline Gliomas (DMG) on polyamine pathway (Khan et al.,2021). Disruption this with synthesis inhibitor DFMO, transport AMXT1501, potently inhibited DMG tumors, yielding unprecedented survival in-vivo. We hypothesized that dual targeting could similarly suppress growth in other aggressive brain tumors....
Abstract BACKGROUND Aberrant epigenetic regulation is a hallmark of Diffuse Midline Glioma (DMG), an incurable pediatric brain tumor. The H3K27M driver histone mutation leads to transcriptional dysregulation, indicating that targeting the epigenome and transcription may be key therapeutic strategy against this aggressive cancer. One such target Facilitates Chromatin Transcription (FACT) chaperone. FACT targeted by curaxin compound CBL0137 which currently in Phase I/II Children’s Oncology...
Abstract BACKGROUND Diffuse Midline Glioma (DMG) has a dire prognosis, with mortality rate nearing 100%. In the past, children diagnosed Acute Lymphoblastic Leukemia (ALL) faced similar prognosis until multi-agent chemotherapy revolutionized their survival rates. We hypothesized that implementing comprehensive treatment strategy for DMG could yield efficacy. This study aimed to test safety and efficacy of sequential, intensive, combinations targeting epigenetic/chromatin modification...
Diffuse intrinsic pontine glioma (DIPG), is an aggressive form of paediatric high-grade (pHGG) that affects children below the age 10 months. The survival period for a child suffering from DIPG has not changed in decades (approximately months). This pattern similar most pHGG; even though more extended, tumour recurrence and death are almost inevitable. primarily due to presence blood-brain barrier (BBB), which blocks entry therapeutics into brain, also heterogeneity associated with central...
Aim: The purpose of this study is to examine the total antioxidant capacity (TAC) as a biomarker investigate oxidative stress in different pathological conditions. primary goal compare TAC levels saliva before and after restoration carious teeth. Additionally, aims explore potential differences between genders with intention establishing possible link salivary dental caries. Materials Methods: In research, we employed random selection process assemble two cohorts: Group I, comprising 27 male...
Abstract Dental caries being the most prevalent disease worldwide usually ends in pulpitis due to negligence of patient and caretaker. The major diagnostic factor followed deciding status as, reversible or irreversible, is severity intensity pain. Traditionally, a tooth diagnosed as irreversible results removal coronal radicular pulp resulting non-vitality tooth. This case report describes use vital therapy (VPT) three paediatric patients with primary teeth showing signs symptoms suggestive...
To evaluate and compare the antibacterial efficacy horizontal depth of penetration various irrigants into dentinal tubules when used alone combined with lasers.An experimental study was done on 42 single-rooted teeth. Access cavity preparation canals were enlarged up to a ProTaper file size F2 length 25 mm. They inoculated 0.1 mL Enterococcus faecalis samples randomly assigned six different groups seven teeth each. The following irrigation systems individually in combinations-normal saline,...
LiF and :Dy thermoluminescent dosimeter were used to measure x-ray dose at high atomic number interfaces. Backscattered factor was measured lead interface in polystyrene phantoms. Results are discussed. (AIP)
The present study was undertaken to standardise the conditions for activity optimisation of agarases produced by three distinct strains agar degrading bacteria viz, Flammeovirga yaeyamensisAM5.A, Aliagarivorans marinusAM17.E1 and taiwanensisA69.B2 (GenBank Acc.Nos.MT473965; MT475710 MT473967 respectively) isolated from coral reef ecosystems along southern coast India.Agarase F. yaeyamensis exhibited highest at 40°C, while A. marinus taiwanensis had peak 50°C.The optimal pH incubation time...
The diagnostic X ray (50-120 kVp) response characteristics of a TLD (thermoluminescence dosemeter) badge currently in use for countrywide personnel monitoring radiation workers India is described. consists three CaSO4:Dy Teflon discs, below: (i) Cu+Al filters, (ii) Perspex, and (iii) an open window. Its underneath the protective lead apron(s) as well its angular dependence are reported. Two different dose evaluation procedures described their relative accuracies discussed.
<div>Abstract<p>For one-third of patients with pediatric cancer enrolled in precision medicine programs, molecular profiling does not result a therapeutic recommendation. To identify potential strategies for treating these high-risk patients, we performed <i>in vitro</i> screening 125 patient-derived samples against library 126 anticancer drugs. Tumor cell expansion did influence drug responses, and 82% the screens on expanded tumor cells were completed while still...
<div>Abstract<p>For one-third of patients with pediatric cancer enrolled in precision medicine programs, molecular profiling does not result a therapeutic recommendation. To identify potential strategies for treating these high-risk patients, we performed <i>in vitro</i> screening 125 patient-derived samples against library 126 anticancer drugs. Tumor cell expansion did influence drug responses, and 82% the screens on expanded tumor cells were completed while still...
<p>Supplementary Figures</p>