A5058584269- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Gas Sensing Nanomaterials and Sensors
- Gold and Silver Nanoparticles Synthesis and Applications
- 3D Printing in Biomedical Research
- Bacterial biofilms and quorum sensing
- Nanoplatforms for cancer theranostics
- Bone Metabolism and Diseases
- Advancements in Transdermal Drug Delivery
- Dental Erosion and Treatment
- Periodontal Regeneration and Treatments
- Sphingolipid Metabolism and Signaling
- Coenzyme Q10 studies and effects
- Advancements in Battery Materials
- Drug Solubulity and Delivery Systems
- Antimicrobial Peptides and Activities
- Advanced Chemical Sensor Technologies
- Immune cells in cancer
- Adsorption and biosorption for pollutant removal
Monash University
2024
The University of Queensland
2019-2023
Brisbane School of Theology
2019-2020
Institute of Bioengineering and Nanotechnology
2019
The prognosis of brain cancers such as glioblastoma remains poor despite numerous advancements in the field neuro-oncology. presence blood barrier (BBB) along with highly invasive and aggressive nature presents a difficult challenge for developing effective therapies. Temozolomide (TMZ) is first line agent used clinic it has been useful increasing patient survival rates. However, TMZ suffers from issues related to its pharmacokinetics, short plasma half-life (2 h), subjected P-gp efflux,...
Deoxyribonuclease I (DNase I) was loaded and delivered by silver-doped mesoporous silica nanoparticles (MSN-Ag) for biofilm treatments.
Bioactive membranes with growth factors that mimic the physiological microenvironment of periodontal tissues have shown great potential for guided tissue regeneration (GTR). However, loss bioactivity and uncontrolled drug release in conventional limit their efficacy. In addition, local infection control ability would provide additional benefits to regeneration. this work, nanoengineered factor antibiotic delivery capabilities were developed achieve dual functions efficient GTR. Mesoporous...
The blood brain barrier (BBB) and tumour (BTB) remain a major roadblock for delivering therapies to treat cancer. Amongst cancers, glioblastoma (GBM) is notoriously difficult due the challenge of chemotherapeutic drugs across BBB into microenvironment. Consequently, GBM has high rates recurrence. Currently, limited numbers chemotherapies are available that can cross GBM. Nanomedicine an attractive solution treating as it augment drug penetration heterogeneous site. However, very few...
Vancomycin (Van) is an antibiotic of choice for many drug resistant infections but cannot be given orally due to its poor permeability. Encapsulation within MSNs improved gastrointestinal permeation and provided controlled release.
Coenzyme Q10 is a potent antioxidant that plays an important role in the maintenance of various biochemical pathways body and has wide range therapeutic applications. However, it low aqueous solubility oral bioavailability. Mesoporous silica nanoparticles (MCM-41 SBA-15 types) exhibiting varying pore sizes modified with phosphonate amino groups were used to study influence structure surface chemistry on solubility, vitro release profile, intracellular ROS inhibition activity coenzyme Q10....
Nanoparticle based permeation enhancers have the potential to improve oral delivery of biologics. Recently, solid silica nanoparticles were discovered intestinal permeability peptides and proteins via transient opening gut epithelium. In this study, we developed small-sized (∼60 nm) virus-like (VSNP) as a reversible next generation non-toxic enhancer for Our results show that anionic VSNP showed better permeation-enhancing effect than same sized spherical Stöber by enhancing apparent insulin...
MicroRNA (miRNA) based therapy for bone repair has shown promising results regulating stem cell proliferation and differentiation, an efficient stable vector delivery of microRNA is needed. The present study explored the stability functionality lyophilized mesoporous silica nanoparticles with core-cone structure coated polyethylenimine (MSN-CC-PEI) as a system delivering Rattus norvegicus (rno)-miRNA-26a-5p into rat marrow mesenchymal cells (rBMSCs) to promote their osteogenic...
Through 3D printing (3DP), many parameters of solid oral dosage forms can be customised, allowing for truly personalised medicine in a way that traditional pharmaceutical manufacturing would struggle to achieve. One the options customisation involves dose titration, gradual weaning medication at intervals smaller than what is available commercially. In this study we demonstrate high accuracy and precision 3DP titration caffeine, selected due its global prevalence as behavioural drug...
The presence of the blood-brain barrier (BBB) limits delivery therapies into brain. There has been significant interest in overcoming BBB for effective to Inorganic nanomaterials, especially silica nanoparticles with varying surface chemistry and topology, have recently used as permeation enhancers oral protein delivery. In this context, sizes chemistries employed overcome barrier; however, there is no report examining effect nanoscale roughness on permeability. This paper reports influence...
Micro-ribonucleic acid (miRNA)-based therapies show advantages for bone regeneration but need efficient intracellular delivery methods. Inorganic nanoparticles such as mesoporous bioactive glass (MBGN) and silica (MSN) have received growing interest in the of nucleic acids. This study explores capacity MBGN MSN delivering miRNA to marrow mesenchymal stem cells (BMSC) regenerative purposes, with a focus on comparing two terms cell viability, transfection efficiency, osteogenic actions....
3D printing of titanium (Ti) metal has potential to transform the field personalised orthopaedics and dental implants. However, impacts controlled surface topographical features printed Ti implants on their interactions with cellular microenvironment incorporation biological growth factors, which are critical in guiding integration bone, not well studied. In present study, we explore role topological using an anodised titania nanotube (TiNT) layer immune cell interaction ability deliver...
Silica nanoadsorbents with a gradient of sulfur content higher density at the external part enable effective decontamination mercury.
Long-term occlusion of dentin tubules is a challenge due to the relatively easy removal inorganic or organic materials used occlude them by abrasion erosion treated surface. To overcome this problem, current work aimed develop combination nanomaterial system enable rapid and stable tubules. A large-sized calcium-doped silica (187 nm, Ca-DMSN-L) small-sized phosphate-doped (74 P-DMSN-S) were fabricated mixed (denoted as L + S; dendritic mesoporous denoted DMSN). Rapid dense was achieved...