Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing (M1). However, the underlying mechanism and structure–function relationship remain unclear. We report magnetite IONPs are more effective compared hematite in M1 polarization tumor suppression. Moreover, specifically rely on interferon regulatory factor 5 signaling pathway for down-regulate M2-assoicated arginase-1. This...

The design of smart nanocarriers that could recognize and differentiate cancer cells normal is great importance in drug delivery. Here we report the first example cell-specific degradable dendritic mesoporous organosilica nanoparticles (DDMONs). A unique pore structure-dependent glutathione (GSH)-responsive degradation behavior revealed: rates two with different sizes are similar ("leveling effect"), while large-pore DDMONs show a faster rate than small-pore relatively high intracellular GSH...

Plasmid DNA molecules with unique loop structures have widespread bioapplications, in many cases relying heavily on delivery vehicles to introduce them into cells and achieve their functions. Herein, we demonstrate that control over delicate nanotopography of silica nanoparticles as plasmid vectors has significant impact the transfection efficacy. For rambutan-, raspberry-, flower-like morphologies composed spike-, hemisphere-, bowl-type subunit nanotopographies, respectively, rambutan-like...

Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death activating cells. A simple physical mixture of chemodrugs in combination with blockades show synergistically concurrently enhanced chemo-immunotherapy efficacy, inhibiting growth both treated...

Abstract The direct depletion of lactate accumulated in the tumor microenvironment holds promise for cancer therapy but remains challenging. Herein, we report a one‐pot synthesis openwork@ dendritic mesoporous silica nanoparticles (ODMSNs) to address this problem. ODMSNs self‐assembled through time‐resolved lamellar growth mechanism feature an openworked core and shell, both constructed by nanosheets ≈3 nm. With large pore size, high surface area volume, exhibited loading capacity (>0.7 g...

Utilizing chemotherapeutics to induce immunogenic cell death (ICD) is a promising strategy sensitize tumor cells and anticancer immunity. However, the application of traditional ICD inducers, such as chemodrugs, largely hindered by their low selectivity severe side effects. Here, new unitized nanoinducer with high potency cancer specificity reported achieve effective immunotherapy. This composed disulfide-bond-incorporated organosilica nanoparticles, curcumin (CUR), iron oxide which can...

Modulation of tumor-associated macrophages (TAMs) holds promise for cancer treatment, mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the antitumor activity is often limited by anti-inflammatory factors in tumor microenvironment. Moreover, metabolic function TAMs also critical to progression. However, there are a few strategies that can simultaneously regulate both inflammatory functions achieve safe potent TAMs. Herein, we demonstrate an iron-based...

Nitric oxide (NO) has many important biological functions; however, it been a long-standing challenge to utilize the exogenous NO donor itself in activation of macrophages for cancer immunotherapy. Herein, we report synthesis nanoparticle-based delivery platform with rational design effective and macrophage activation. S-Nitrosothiol (SNO) modified organosilica nanoparticles tetrasulfide-containing composition produced higher level intracellular than their bare silica counterparts...

Nowadays, protein therapeutics receive unprecedented recognition for their great potential in the treatment of a variety diseases. The efficacy native therapeutic proteins is limited by intrinsic poor stability and cell membrane permeability. Tremendous efforts have been devoted to developing efficient delivery systems. past decade has witnessed development successful application silica-based nanoparticles (SiNPs) as carriers. This review focuses on recent advances SiNPs disease cancer...

Abstract Effective messenger RNA (mRNA) transfection in hard‐to‐transfect cells delivered by vectors is a long‐standing challenge. Now it hypothesized that the high intracellular glutathione level associated with suppressed mRNA translation. This theory leads to new design principle of next‐generation vectors: nanoparticles depletion chemistry upregulate translation and enhance transfection, which beneficial for delivery vitro vivo.

Abstract Using dendritic mesoporous silica nanoparticles (DMSNs) for quantum dots (QDs) enrichment and signal amplification is an emerging strategy improving the detection sensitivity of lateral flow immunoassay (LFIA). In this study, a new convenient approach developed to prepare water‐dispersible DMSNs‐QDs. A series DMSNs with various diameters (138, 251, 368, 471 nm) are studied loading QDs LFIA applications. The resultant DMSNs‐QDs exhibit high fluorescence retention 81.8%. increase in...

The combination of immune checkpoint blockade (ICB) and chemotherapy has shown significant potential in the clinical treatment various cancers. However, circulating regeneration PD-L1 within tumor cells greatly limits efficiency chemo-immunotherapy consequent patient response rates. Herein, we report synthesis a nanoparticle-based inhibitor (FRS) with rational design for effective endogenous suppression. nanoinhibitor is achieved through self-assembly fluoroalkylated competitive peptides...

Fractal objects such as snowflakes and trees are ubiquitous in nature. However, fractal nanoparticles with uniform morphology controllable structures difficult to make. Herein, using a fractal-in-a-sphere strategy, we report the confined self-assembly of silica tunable generations sizes. One advantage has been demonstrated enzyme delivery for parasite oocyst control. The exhibited better oocysticidal performance compared other due combined effects enhanced adhesion, penetration across wall,...

Hollow spheres are charming objects in nature. In this work, an unexpected deflation-inflation asymmetric growth (DIAG) strategy is reported, generating hollow nanoparticles with tailored concave geometry for interface catalysis. Starting from aminophenol-formaldehyde (APF) nanospheres where the interior crosslinking degree low, fully deflated nanobowls obtained after etching by acetone. Due to APF and repolymerization reactions occuring asymmetrically within a single particle, autonomous...

Abstract MnO 2 nanoparticles have been widely employed in cancer immunotherapy, playing a subsidiary role assisting immunostimulatory drugs by improving their pharmacokinetics and/or creating favorable microenvironment. Here, the stereotype of immunotherapy is challenged. This study unravels an intrinsic immunomodulatory property as unique nutrient‐responsive immunogenic cell death (ICD) inducer, capable directly modulating immunosurveillance toward tumor cells. nanoflowers (MNFs)...

Inhibiting the formation of new tumor blood vessels (so-called antiangiogenesis) and obstructing established ones are two primary strategies in vasculature targeted therapy. However, therapeutic outcome conventional methodologies relying on only one mechanism is rather limited. Herein, first example ultrasmall responsively aggregatable nanochelators that can intrinsically fulfill both antivasculature functions as well high renal clearable efficiency introduced. The with sub-6 nm sizes...

Designed Janus silica nanoparticles can stimulate stronger phagocytosis and exhibit higher cargo transport across an <italic>in vitro</italic> epithelial monolayer model mimicking the human intestinal epithelium.

It is intriguing and challenging to utilize aerogels with a very high surface area enhance the light-harvesting capacity of photoanode. Here we demonstrate highly efficient aerogel-modified photoanodes by modifying both aerogel's microstructure photoanode's functions. A low-cost sol–gel ambient-drying route developed fabricate high-quality SiO2 SiO2–TiO2 hybrid tunable (500–1170 m2 g−1) packing density (0.03–0.27 g cm−3). Two series integrating aerogel microparticles TiO2 nanocrystallites...