A5000738064- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Sphingolipid Metabolism and Signaling
- Bacteriophages and microbial interactions
- Infant Nutrition and Health
- Oral Health Pathology and Treatment
- Mesoporous Materials and Catalysis
- Lipid Membrane Structure and Behavior
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Inhalation and Respiratory Drug Delivery
- Phytochemicals and Antioxidant Activities
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- COVID-19 Impact on Reproduction
- Neonatal and Maternal Infections
University of South Australia
1955-2024
The University of Queensland
2017-2020
Brisbane School of Theology
2018
Narsee Monjee Institute of Management Studies
2010-2011
Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. length coverage on particles are adjustable. Compared to spherical a solid structure (Stöber spheres) large-pore symmetrical MSNs fully covered tails, asymmetrical (HTMSNs) show superior hemocompatibility due reduced membrane deformation of red blood cells decreased level...
Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death activating cells. A simple physical mixture of chemodrugs in combination with blockades show synergistically concurrently enhanced chemo-immunotherapy efficacy, inhibiting growth both treated...
Abstract Hypoxia‐activated prodrugs have brought new opportunities for safe and effective tumor ablation, but their therapeutic efficacy is limited by insufficient activation in microenvironments. Herein, a novel cascade delivery system with tandem functions integrating hypoxia‐activated prodrug (AQ4N) glucose oxidase (GOx) designed to improve its efficacy. Innovative yolk–shell organosilica nanoparticles tetrasulfide bridged composition, small‐pore yolk, large‐pore shell featuring...
Infectious diseases remain a major burden in today’s world, causing high mortality rates and significant economic losses, with >9 million deaths per year predicted by 2030. Invasion of host cells intracellular bacteria poses treatment challenges due to the poor permeation antimicrobials into infected cells. To overcome these limitations, mesoporous silica nanoparticles (MSNP) loaded antibiotic rifampicin were investigated as nanocarrier system for bacterial infection specific interest...
Asymmetric mesoporous silica nanoparticles with a head–tail structure are potent immunoadjuvants in delivering peptide antigen, generating higher antibody immune response mice compared to their symmetric counterparts.
An urgent demand exists for the development of effective carrier systems that systematically enhance cellular uptake and localization antibiotic drugs treatment intracellular pathogens. Commercially available antibiotics suffer from poor penetration, restricting their efficacy against pathogens hosted protected within phagocytic cells. In this study, potency rifampicin small colony variants Staphylococcus aureus was improved through encapsulation a strategically engineered cell-penetrant...
MP-A08 is a novel sphingosine kinase 1 (SPHK1) inhibitor with activity against acute myeloid leukemia (AML). A rationally designed liposome-based encapsulation and delivery system has been shown to overcome the physicochemical challenges of enable its effective for improved efficacy survival mice engrafted human AML in preclinical models. To establish therapies that AML’s heterogeneous nature, here we explored combination MP-A08-loaded liposomes both standard chemotherapy, cytarabine,...
Mesoporous silica nanoparticles are reported as adjuvants in nanovaccines generating robust antigen-specific immunity. However, the effect of surface chemistry initiating and modulating immune response remains largely unexplored. In this study, mesoporous nanorods (MSNRs) modified with NH2 C18 groups to investigate influence functional (OH, , ) on their adjuvant efficacy. It is found that compared OH groups, hydrophobic modification significantly enhances antigen uptake by presenting...
Benzene-bridged dendritic mesoporous organosilica nanoparticles significantly improve the catalytic activity and stability of lipase.
Nanomaterials have provided an emerging solution to improve the efficacy of cancer vaccines against malignant tumors. However, developing nanoparticles possessing both potent immunoadjuvant and co-delivery activities without tedious functionalization remains challenging. In present work, we report that pristine benzene-bridged mesoporous organosilica are a novel platform for antigen cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG, toll-like receptor 9 agonist). It is shown chemical...
Strategies to improve the uptake of particulate delivery systems macrophages are required for advancement therapeutic solutions a range disease states, including human immunodeficiency virus (HIV), tuberculosis, and cystic fibrosis. In this study, poly(lactic-co-glycolic) acid (PLGA) nanoparticles were combined with lipid nanoparticles, via process spray drying, overcome physiochemical limitations associated individual precursor systems. The hybrid nanoparticle-in-microparticle structure was...
Acute myeloid leukemia (AML) kills 75% of patients and represents a major clinical challenge with need to improve on current treatment approaches. Targeting sphingosine kinase 1 novel ATP-competitive-inhibitor, MP-A08, induces cell death in AML. However, limitations MP-A08's "drug-like properties" (solubility, biodistribution, potency) hinder its pathway the clinic. This study demonstrates liposome-based delivery system MP-A08 that exhibits enhanced potency against AML cells....
Intracellular bacteria are inaccessible and highly tolerant to antibiotics, hence a major contributor the global challenge of antibiotic resistance recalcitrant clinical infections. This, in tandem with stagnant antibacterial discovery, highlights an unmet need for new delivery technologies treat intracellular infections more effectively. Here, we compare uptake, delivery, efficacy rifampicin (Rif)-loaded mesoporous silica nanoparticles (MSN) organo-modified (ethylene-bridged) MSN (MON) as...
This work reports the significance of carbonisation temperature mesoporous carbon hollow spheres (MCHS) in therapeutic protein delivery.
Leaves of Piper betle L. (Piperaceae) have been shown to possess antimicrobial, gastroprotective, wound healing, hepatoprotective and antioxidant properties [1]. The antimicrobial activity betel leaves relevant in oral care lead the investigation its anti-plaque activity. Five varieties (Banarasi, Calcutta, Desi, Maghai Puna) were subjected successive extractions at room temperature with various solvents (hexane, diethyl ether, ethyl acetate, ethanol, hydro-ethanol water). Two (Banarasi...
Abstract In this present study we aim to evaluate in vitro antioxidant and free radical scavenging potential of different extract Butea Frondosa Roxb . Flowers system viz. Radical activity by DPPH reduction lipid peroxidation assay (TBARS). All extracts have level activity. The was expressed as the inhibitory concentration (IC 50 ). conclusion indicates that alcoholic n -butanol fraction which is obtained solvent partition flower showed significant both methods can be a source natural antioxidants.