A5090775544- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Domain Adaptation and Few-Shot Learning
- Neuroscience and Neural Engineering
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Barrier Structure and Function Studies
- GDF15 and Related Biomarkers
- Renal and related cancers
- Cholinesterase and Neurodegenerative Diseases
- Zebrafish Biomedical Research Applications
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
University of South Australia
2018-2024
Southwest Medical University
2022
Abstract Background The limited neuronal differentiation of the endogenous or grafted neural stem cells (NSCs) after brain injury hampers clinic usage NSCs. Panax notoginseng saponins (PNS) were extensively used for their clinical value, such as in controlling blood pressure, glucose, and inhibiting apoptosis enhancing protection, but whether not it exerts an effect promoting NSCs is completely unclear potential underlying mechanism requires further exploration. Methods Firstly, we...
Postoperative cognitive dysfunction (POCD) is serious disorder in the central nervous system common aged patients after anesthesia. Although its clinical symptoms are well recognized, however, molecular etiology of POCD remains unrevealed. Similarly, neither gold standard diagnosis nor effective treatment available for until present. Therefore, we aimed to explore mechanism this through investigating lncRNAs and mRNAs associated with human investigate their underlying regulatory pathways. In...
Elucidation of the biological functions extracellular vesicles (EVs) and their potential roles in physiological pathological processes is an expanding field research. In this study, we characterized USC-derived EVs studied capacity to modulate human immune response vitro. We found that are a heterogeneous population, ranging size from micro-vesicles (150 nm-1 μm) down exosomes (60-150 nm). Regarding immunomodulatory functions, upon isolation, nm) induced B cell proliferation IgM antibody...
p75 neurotrophin receptor (p75 NTR ) has been implicated in Alzheimer's disease (AD).However, whether is involved Tau hyperphosphorylation, one of the pathologies observed AD, remains unclear.In our previous study, extracellular domain blocked amyloid beta (Aβ) toxicity and attenuated Aβ-induced hyperphosphorylation.Here we show that, absence Aβ, regulates phosphorylation transgenic mice with P301L human mutation (pR5).The knockout pR5 Tau.In addition, elevated activity kinases responsible...
A single-nucleotide polymorphism (SNP) is an alteration in one nucleotide a certain position within genome. SNPs are associated with disease susceptibility. However, the influences of on pathogenesis neonatal hypoxic-ischemic brain damage remain elusive. Seven-day-old rats were used to establish hypoxic ischemic encephalopathy model. and expression profiles mRNAs analyzed model using RNA sequencing. Genes exhibiting identified studied by gene ontology pathway analysis identify their possible...
Abstract Background Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This study was conducted to determine specific potential mechanism induced cerebral injury. Methods Here, (HI) animal models were established primary cortical neurons subjected oxygen–glucose deprivation (OGD) mimic HIE model vivo vitro. The HI-induced neurological...
To investigate the therapeutic efficacy of Scutellarin (SCU) on neurite growth and neurological functional recovery in neonatal hypoxic-ischemic (HI) rats. Primary cortical neurons were cultured to detect effect SCU cell viability under oxygen-glucose deprivation (OGD). Double immunofluorescence staining Tuj1 TUNEL then observed apoptosis vitro,and double NEUN was performed examine neuronal brain tissues after HI vivo. Pharmacological also evaluated rats by neurobehavioral tests, triphenyl...
Abstract The interplay between mesenchymal stem cells (MSCs) and immune has been studied for MSCs isolated from different tissues. However, the immunomodulatory capacity of urine (USCs) not adequately researched. present study reports on effect USCs peripheral blood lymphocytes. were characterized before coculture with resting anti-CD3/CD28 bead stimulated Similarly to bone marrow (BM-MSCs), inhibited proliferation activated T lymphocytes induced their apoptosis. they also strong activation,...
Spinal cord injury (SCI) is a fatal disease that can cause severe disability. Cortical reorganization subserved the recovery of spontaneous function after SCI, although potential molecular mechanism in this remote control largely unknown. Therefore, using proteomics analysis, RNA interference/overexpression, and CRISPR/Cas9 vivo vitro , we analyzed how network functions neurological improvement, especially motor spinal transection (SCT) via regulation cerebral cortex. We discovered...
Cerebral ischemia (CI) is a severe brain injury resulting in variety of motor impairments combined with secondary remote organs, especially the lung. This condition occurs due to insufficient blood supply during infancy. However, it has molecular linkage that needs be thoroughly covered. Here, we report on role vascular endothelial growth factor C (VEGFC) lung induced by CI. The middle cerebral artery occlusion (MCAO) was depended establish animal model Rats were used and confirmed through...
Optimal exercise can promote the development of cognitive functions. Nevertheless, mechanisms that elicit these positive effects still need to be elucidated. Insulin-like growth factor 2 (IGF2) is known act as a potent enhancer memory and functions, whereas mechanism by which IGF2 regulates functions in terms moderate treadmill remains largely vague. In study, rats were subjected low-, moderate-, high-intensity training for 6 weeks. Then, Morris water maze test was used investigate spatial...
Kidney is a vital organ that maintains the homeostasis in terms of acid-balance, toxin filtration and blood pressure control. malfunction can be fatal renal research administers testing pharmaceutical agents or stem cells rodents to study their therapeutic efficacy. However, targeted delivery into mice kidney strenuous may require laparotomy. Here we present direct method for cell transplantation drug injection kidney. The simple performed non-invasively with avoidance surgical intervention...